The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Arabidopsis CLV3 Peptide Directly Binds CLV1 Ectodomain
Abstract
CLV1, which encodes a leucine-rich repeat receptor kinase, and CLV3, which encodes a secreted peptide, function in the same genetic pathway to maintain stem cell populations in Arabidopsis shoot apical meristem. Here, we show biochemical evidence, by ligand binding assay and photoaffinity labeling, that the CLV3 peptide directly binds the CLV1 ectodomain with a dissociation constant of 17.5 nM. The CLV1 ectodomain also interacts with the structurally related CLE peptides, with distinct affinities depending on the specific amino acid sequence. Our results provide direct evidence that CLV3 and CLV1 function as a ligand-receptor pair involved in stem cell maintenance.
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Cites
Clark, S. E., Williams, R. W., & Meyerowitz, E. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80239-1 · Cited by 1,373
Signaling of Cell Fate Decisions by CLAVATA3 in Arabidopsis Shoot Meristems
Fletcher, J. C., Brand, U., Running, M. P., Simon, R., & Meyerowitz, E. M. (1999) · Science · doi:10.1126/science.283.5409.1911 · Cited by 1,357
Dodeca-CLE Peptides as Suppressors of Plant Stem Cell Differentiation
Ito, Y., Nakanomyo, I., Motose, H., Iwamoto, K., Sawa, S., Dohmae, N., & Fukuda, H. (2006) · Science · doi:10.1126/science.1128436 · Cited by 667
A Plant Peptide Encoded by CLV3 Identified by in Situ MALDI-TOF MS Analysis
Kondo, T., Sawa, S., Kinoshita, A., Mizuno, S., Kakimoto, T., Fukuda, H., & Sakagami, Y. (2006) · Science · doi:10.1126/science.1128439 · Cited by 500
Self-citationStrabala, T. J., O'Donnell, P. J., Smit, A.-M., Ampomah-Dwamena, C., Martin, E. J., Netzler, N., Nieuwenhuizen, N. J., Quinn, B. D., Foote, H. C. C., & Hudson, K. R. (2006) · Plant Physiology · doi:10.1104/pp.105.075515 · Cited by 200
Cell signaling within the shoot meristem
Fletcher, J. C., & Meyerowitz, E. M. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(99)00033-3 · Cited by 98
Cited by
WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex
Yadav, R. K., Perales, M., Gruel, J., Girke, T., Jönsson, H., & Reddy, G. V. (2011) · Genes & Development · doi:10.1101/gad.17258511 · Cited by 629
Hirakawa, Y., Kondo, Y., & Fukuda, H. (2010) · The Plant Cell · doi:10.1105/tpc.110.076083 · Cited by 567
Osakabe, Y., Yamaguchi-Shinozaki, K., Shinozaki, K., & Tran, L.-S. P. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ers354 · Cited by 384
Twenty years on: The inner workings of the shoot apical meristem, a developmental dynamo
Barton, M. K. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.029 · Cited by 372
Santiago, J., Henzler, C., & Hothorn, M. (2013) · Science · doi:10.1126/science.1242468 · Cited by 357
Metadata
- Authors
- Ogawa, M., Shinohara, H., Sakagami, Y., & Matsubayashi, Y.
- Venue
- Science
- Published
- 2008-01-18
- Volume
- 319
- Issue
- 5861
- Pages
- 294-294
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092212990
- Cited by
- 512
- References
- 6
- FWCI
- 53.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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