Molecular Mechanism for Plant Steroid Receptor Activation by Somatic Embryogenesis Co-Receptor Kinases
Abstract
Steroid Receptor Signaling: Plant brassinosteroids signal to diverse pathways in plant physiology. These steroid hormones are perceived at the cell surface, where they bind to the receptor BRASSINOSTEROID INSENSITIVE 1 (BRI1). Santiago et al. (p. 889 , published online 8 August) now show that somatic embryogenesis receptor kinase 1 (SERK1) complexes with BRI1. Together, these receptor kinases form the steroid binding site, with the hormone acting as a “molecular glue” that stabilizes the interaction. Hormone-induced heteromerization of BRI1 with SERK1 leads to the activation of the cytoplasmic signaling cascade, triggering plant growth and differentiation.
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Brassinosteroids are phytohormones that function as molecular glues by linking the membrane receptor kinase BRI1 to its coreceptors.
“brassinosteroids are phytohormones that function as MGs by linking the membrane receptor kinase BRI1 to its coreceptors (Fig. 3A and 4).71,88”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [71]
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- Authors
- Santiago, J., Henzler, C., & Hothorn, M.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Hothorn, Michael
- Venue
- Science
- Published
- 2013-08-23
- Volume
- 341
- Issue
- 6148
- Pages
- 889-892
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033983786
- Cited by
- 357
- References
- 45
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 23 · 2023: 22 · 2022: 13 · 2021: 20 · 2020: 24 · 2019: 26 · 2018: 37 · 2017: 33 · 2016: 41 · 2015: 37 · 2014: 37 · 2013: 10
- FWCI
- 50.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- DORA PSI (Paul Scherrer Institute) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Reproductive Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- brassinosteroid signaling, BRI1, SERK1, leucine-rich repeat domain, crystal structure, missense mutations, plant growth and development
- MeSH terms
- Amino Acid Sequence, Molecular Sequence Data, Protein Kinases, Receptors, Steroid, Protein Structure, Secondary, Protein Structure, Tertiary, Crystallography, X-Ray, Mutation, Missense, Arabidopsis Proteins, Brassinosteroids
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