Cited by 357Plant Molecular Biology ResearchPlant Reproductive BiologyReceptor Mechanisms and Signaling

Molecular Mechanism for Plant Steroid Receptor Activation by Somatic Embryogenesis Co-Receptor Kinases

Santiago, Julia, Henzler, Christine, Hothorn, Michael·2013·Science

Abstract

Steroid Receptor Signaling: Plant brassinosteroids signal to diverse pathways in plant physiology. These steroid hormones are perceived at the cell surface, where they bind to the receptor BRASSINOSTEROID INSENSITIVE 1 (BRI1). Santiago et al. (p. 889 , published online 8 August) now show that somatic embryogenesis receptor kinase 1 (SERK1) complexes with BRI1. Together, these receptor kinases form the steroid binding site, with the hormone acting as a “molecular glue” that stabilizes the interaction. Hormone-induced heteromerization of BRI1 with SERK1 leads to the activation of the cytoplasmic signaling cascade, triggering plant growth and differentiation.

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Crossref · 10.1126/science.1242468

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45 of 45 references verified0 citation errors · 0 not checkable

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  • Brassinosteroids are phytohormones that function as molecular glues by linking the membrane receptor kinase BRI1 to its coreceptors.

    “brassinosteroids are phytohormones that function as MGs by linking the membrane receptor kinase BRI1 to its coreceptors (Fig. 3A and 4).71,88”

    From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [71]

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Authors
Santiago, J., Henzler, C., & Hothorn, M.
Affiliations
Max Planck Society (DE)
Corresponding author
Hothorn, Michael
Venue
Science
Published
2013-08-23
Volume
341
Issue
6148
Pages
889-892
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2033983786
Cited by
357
References
45
Citations by year
2026: 17 · 2025: 17 · 2024: 23 · 2023: 22 · 2022: 13 · 2021: 20 · 2020: 24 · 2019: 26 · 2018: 37 · 2017: 33 · 2016: 41 · 2015: 37 · 2014: 37 · 2013: 10
FWCI
50.31
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • DORA PSI (Paul Scherrer Institute) (submittedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Reproductive Biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
brassinosteroid signaling, BRI1, SERK1, leucine-rich repeat domain, crystal structure, missense mutations, plant growth and development
MeSH terms
Amino Acid Sequence, Molecular Sequence Data, Protein Kinases, Receptors, Steroid, Protein Structure, Secondary, Protein Structure, Tertiary, Crystallography, X-Ray, Mutation, Missense, Arabidopsis Proteins, Brassinosteroids

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