The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Initiating and Cancer-Propagating Cells in TEL-AML1 -Associated Childhood Leukemia
Abstract
Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor–B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. By studying a monochorionic twin pair, one preleukemic and one with frank leukemia, we establish the lineal relationship between these “cancer-propagating” cells and the preleukemic cell in which the TEL-AML1 fusion first arises or has functional impact. Analysis of TEL-AML1 –transduced cord blood cells suggests that TEL-AML1 functions as a first-hit mutation by endowing this preleukemic cell with altered self-renewal and survival properties.
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Cites
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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.
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Cited by
Pui, C.-H., Robison, L. L., & Look, A. T. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60457-2 · Cited by 1,564
Visvader, J. E. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,449
Stem cell concepts renew cancer research
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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
Jan, M., Snyder, T. M., Corces-Zimmerman, M. R., Vyas, P., Weissman, I. L., Quake, S. R., & Majeti, R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004315 · Cited by 721
A causal mechanism for childhood acute lymphoblastic leukaemia
Greaves, M. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0015-6 · Cited by 558
Self-citation
Metadata
- Authors
- Hong, D., Gupta, R., Ancliff, P., Atzberger, A., Brown, J., Soneji, S., Green, J., Colman, S., Piacibello, W., Buckle, V., Tsuzuki, S., Greaves, M., & Enver, T.
- Venue
- Science
- Published
- 2008-01-18
- Volume
- 319
- Issue
- 5861
- Pages
- 336-339
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014345967
- Cited by
- 397
- References
- 17
- FWCI
- 47.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hong, D., Gupta, R., Ancliff, P., Atzberger, A., Brown, J., Soneji, S., Green, J., Colman, S., Piacibello, W., Buckle, V., Tsuzuki, S., Greaves, M., & Enver, T. (2008). Initiating and Cancer-Propagating Cells in TEL-AML1 -Associated Childhood Leukemia. Science. https://doi.org/10.1126/science.1150648
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