The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops
Open accessAbstract
A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators also have a positive feedback loop, raising the question of what advantages the extra loop imparts. Through computational studies, we show that it is generally difficult to adjust a negative feedback oscillator's frequency without compromising its amplitude, whereas with positive-plus-negative feedback, one can achieve a widely tunable frequency and near-constant amplitude. This tunability makes the latter design suitable for biological rhythms like heartbeats and cell cycles that need to provide a constant output over a range of frequencies. Positive-plus-negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant.
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Cites
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., et al. (2004) · Science · doi:10.1126/science.1099962 · Cited by 1,186
Smolen, P., Baxter, D. A., & Byrne, J. H. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.2.c531 · Cited by 185
Cited by
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Novák, B., & Tyson, J. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2530 · Cited by 1,137
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Defining Network Topologies that Can Achieve Biochemical Adaptation
Ma, W., Trusina, A., El-Samad, H., Lim, W. A., & Tang, C. (2009) · Cell · doi:10.1016/j.cell.2009.06.013 · Cited by 919
Self-citationKell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Metadata
- Authors
- Tsai, T. Y.-C., Choi, Y. S., Ma, W., Pomerening, J. R., Tang, C., & Ferrell, J. E.
- Venue
- Science
- Published
- 2008-07-04
- Volume
- 321
- Issue
- 5885
- Pages
- 126-129
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051497876
- Cited by
- 690
- References
- 2
- FWCI
- 19.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Tsai, T. Y.-C., Choi, Y. S., Ma, W., Pomerening, J. R., Tang, C., & Ferrell, J. E. (2008). Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops. Science. https://doi.org/10.1126/science.1156951
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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