The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Molecular Determinant for the Establishment of Sister Chromatid Cohesion
Abstract
Chromosome segregation, transcriptional regulation, and repair of DNA double-strand breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes (sister chromatids) together to mediate sister chromatid cohesion. The mechanism of how cohesion is established is unknown. We found that in budding yeast, the head domain of the Smc3p subunit of cohesin is acetylated by the Eco1p acetyltransferase at two evolutionarily conserved residues, promoting the chromatin-bound cohesin to tether sister chromatids. Smc3p acetylation is induced in S phase after the chromatin loading of cohesin and is suppressed in G 1 and G 2 /M. Smc3 head acetylation and its cell cycle regulation provide important insights into the biology and mechanism of cohesion establishment.
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Cites
Wapl controls the dynamic association of cohesin with chromatin
Kueng, S., Hegemann, B., Peters, B. H., Lipp, J. J., Schleiffer, A., Mechtler, K., & Peters, J.-M. (2006) · Cell · doi:10.1016/j.cell.2006.09.040 · Cited by 624
Cited by
Functions and mechanisms of non-histone protein acetylation
Narita, T., Weinert, B. T., & Choudhary, C. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0081-3 · Cited by 1,232
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
Deardorff, M. A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., et al. (2012) · Nature · doi:10.1038/nature11316 · Cited by 577
The cohesin complex and its roles in chromosome biology
Peters, J.-M., Tedeschi, A., & Schmitz, J. (2008) · Genes & Development · doi:10.1101/gad.1724308 · Cited by 532
Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion
Ben-Shahar, T. R., Heeger, S., Lehane, C., East, P., Flynn, H., Skehel, M., & Uhlmann, F. (2008) · Science · doi:10.1126/science.1157774 · Cited by 498
Sun, Z., Chin, Y. E., & Zhang, D. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01639-08 · Cited by 414
Metadata
- Authors
- Ünal, E., Heidinger-Pauli, J. M., Kim, W., Guacci, V., Onn, I., Gygi, S. P., & Koshland, D. E.
- Venue
- Science
- Published
- 2008-07-25
- Volume
- 321
- Issue
- 5888
- Pages
- 566-569
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021859989
- Cited by
- 459
- References
- 1
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ünal, E., Heidinger-Pauli, J. M., Kim, W., Guacci, V., Onn, I., Gygi, S. P., & Koshland, D. E. (2008). A Molecular Determinant for the Establishment of Sister Chromatid Cohesion. Science. https://doi.org/10.1126/science.1157880
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