The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion
Abstract
Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork–associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion. A second set of eco1-1 suppressors inactivate the budding yeast ortholog of the cohesin destabilizer Wapl. Our results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent.
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Cites
Wapl controls the dynamic association of cohesin with chromatin
Kueng, S., Hegemann, B., Peters, B. H., Lipp, J. J., Schleiffer, A., Mechtler, K., & Peters, J.-M. (2006) · Cell · doi:10.1016/j.cell.2006.09.040 · Cited by 624
Toth, A., Ciosk, R., Uhlmann, F., Galova, M., Schleiffer, A., & Nasmyth, K. (1999) · Genes & Development · doi:10.1101/gad.13.3.320 · Cited by 598
Self-citationA Molecular Determinant for the Establishment of Sister Chromatid Cohesion
Ünal, E., Heidinger-Pauli, J. M., Kim, W., Guacci, V., Onn, I., Gygi, S. P., & Koshland, D. E. (2008) · Science · doi:10.1126/science.1157880 · Cited by 459
Cohesion between sister chromatids must be established during DNA replication
Uhlmann, F., & Nasmyth, K. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70463-4 · Cited by 456
Self-citationGandhi, R., Gillespie, P. J., & Hirano, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.061 · Cited by 441
Skibbens, R. V., Corson, L. B., Koshland, D., & Hieter, P. (1999) · Genes & Development · doi:10.1101/gad.13.3.307 · Cited by 437
The boundaries of the silenced HMR domain in Saccharomyces cerevisiae
Donze, D., Adams, C. R., Rine, J., & Kamakaka, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.6.698 · Cited by 373
DNA Double-Strand Breaks Trigger Genome-Wide Sister-Chromatid Cohesion Through Eco1 (Ctf7)
Ünal, E., Heidinger-Pauli, J. M., & Koshland, D. (2007) · Science · doi:10.1126/science.1140637 · Cited by 333
Identification of RFC(Ctf18p, Ctf8p, Dcc1p)
Mayer, M. L., Gygi, S. P., Aebersold, R., & Hieter, P. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00254-4 · Cited by 323
Structure and Stability of Cohesin's Smc1-Kleisin Interaction
Haering, C. H., Schoffnegger, D., Nishino, T., Helmhart, W., Nasmyth, K., & Löwe, J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.030 · Cited by 322
Cited by
Functions and mechanisms of non-histone protein acetylation
Narita, T., Weinert, B. T., & Choudhary, C. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0081-3 · Cited by 1,232
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
Deardorff, M. A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., et al. (2012) · Nature · doi:10.1038/nature11316 · Cited by 577
The cohesin complex and its roles in chromosome biology
Peters, J.-M., Tedeschi, A., & Schmitz, J. (2008) · Genes & Development · doi:10.1101/gad.1724308 · Cited by 532
Sun, Z., Chin, Y. E., & Zhang, D. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01639-08 · Cited by 414
Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl
Nishiyama, T., Ladurner, R., Schmitz, J., Kreidl, E., Schleiffer, A., Bhaskara, V., Bando, M., Shirahige, K., Hyman, A. A., Mechtler, K., et al. (2010) · Cell · doi:10.1016/j.cell.2010.10.031 · Cited by 391
Metadata
- Authors
- Ben-Shahar, T. R., Heeger, S., Lehane, C., East, P., Flynn, H., Skehel, M., & Uhlmann, F.
- Venue
- Science
- Published
- 2008-07-25
- Volume
- 321
- Issue
- 5888
- Pages
- 563-566
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979298341
- Cited by
- 498
- References
- 28
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ben-Shahar, T. R., Heeger, S., Lehane, C., East, P., Flynn, H., Skehel, M., & Uhlmann, F. (2008). Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion. Science. https://doi.org/10.1126/science.1157774
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