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Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells
Open accessAbstract
The prevention of autoimmunity requires the elimination of self-reactive T cells during their development and maturation. The expression of diverse self-antigens by stromal cells in the thymus is essential to this process and depends, in part, on the activity of the autoimmune regulator ( Aire ) gene. Here we report the identification of extrathymic Aire -expressing cells (eTACs) resident within the secondary lymphoid organs. These stromally derived eTACs express a diverse array of distinct self-antigens and are capable of interacting with and deleting naïve autoreactive T cells. Using two-photon microscopy, we observed stable antigen-specific interactions between eTACs and autoreactive T cells. We propose that such a secondary network of self-antigen–expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection.
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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581
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Cross-tissue immune cell analysis reveals tissue-specific features in humans
Domínguez Conde, C., Xu, C., Jarvis, L. B., Rainbow, D. B., Wells, S. B., Gomes, T., Howlett, S. K., Suchanek, O., Polanski, K., King, H. W., et al. (2022) · Science · doi:10.1126/science.abl5197 · Cited by 1,159
Mesenchymal Stem Cells as Therapeutics
Parekkadan, B., & Milwid, J. M. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105309 · Cited by 759
Puel, A., Döffinger, R., Natividad, A., Chrabieh, M., Barcenas-Morales, G., Picard, C., Cobat, A., Ouachée-Chardin, M., Toulon, A., Bustamante, J., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091983 · Cited by 733
Autoimmune Polyendocrine Syndromes
Husebye, E. S., Anderson, M. S., & Kämpe, O. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1713301 · Cited by 466
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Metadata
- Authors
- Gardner, J. M., DeVoss, J. J., Friedman, R. S., Wong, D. J., Tan, Y. X., Zhou, X., Johannes, K. P., Su, M. A., Chang, H. Y., Krummel, M. F., & Anderson, M. S.
- Venue
- Science
- Published
- 2008-08-08
- Volume
- 321
- Issue
- 5890
- Pages
- 843-847
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034402052
- Cited by
- 491
- References
- 1
- FWCI
- 16.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Gardner, J. M., DeVoss, J. J., Friedman, R. S., Wong, D. J., Tan, Y. X., Zhou, X., Johannes, K. P., Su, M. A., Chang, H. Y., Krummel, M. F., & Anderson, M. S. (2008). Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells. Science. https://doi.org/10.1126/science.1159407
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