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Higher-Order Cellular Information Processing with Synthetic RNA Devices
Open accessAbstract
The engineering of biological systems is anticipated to provide effective solutions to challenges that include energy and food production, environmental quality, and health and medicine. Our ability to transmit information to and from living systems, and to process and act on information inside cells, is critical to advancing the scale and complexity at which we can engineer, manipulate, and probe biological systems. We developed a general approach for assembling RNA devices that can execute higher-order cellular information processing operations from standard components. The engineered devices can function as logic gates (AND, NOR, NAND, or OR gates) and signal filters, and exhibit cooperativity. RNA devices process and transmit molecular inputs to targeted protein outputs, linking computation to gene expression and thus the potential to control cellular function.
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Citations
Cited by
Dynamic DNA nanotechnology using strand-displacement reactions
Zhang, D. Y., & Seelig, G. (2011) · Nature Chemistry · doi:10.1038/nchem.957 · Cited by 1,785
The second wave of synthetic biology: from modules to systems
Purnick, P. E. M., & Weiss, R. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2698 · Cited by 1,181
Programmable single-cell mammalian biocomputers
Ausländer, S., Ausländer, D., Müller, M., Wieland, M., & Fussenegger, M. (2012) · Nature · doi:10.1038/nature11149 · Cited by 375
Biomolecular computing systems: principles, progress and potential
Benenson, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3197 · Cited by 373
Next-generation synthetic gene networks
Lu, T. K., Khalil, A. S., & Collins, J. J. (2009) · Nature Biotechnology · doi:10.1038/nbt.1591 · Cited by 365
Metadata
- Authors
- Win, M. N., & Smolke, C. D.
- Venue
- Science
- Published
- 2008-10-17
- Volume
- 322
- Issue
- 5900
- Pages
- 456-460
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2109389103
- Cited by
- 545
- References
- 0
- FWCI
- 19.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Win, M. N., & Smolke, C. D. (2008). Higher-Order Cellular Information Processing with Synthetic RNA Devices. Science. https://doi.org/10.1126/science.1160311
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