Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain
Open accessAbstract
The amyloid-beta peptide (Abeta) plays a central pathophysiological role in Alzheimer's disease, but little is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Abeta concentrations and neurological status, with Abeta concentrations increasing as neurological status improved and falling when neurological status declined. Brain ISF Abeta concentrations were also lower when other cerebral physiological and metabolic abnormalities reflected depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Abeta concentration.
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Urea has been utilized as an independent measure of probe function and recovery in both human and animal brain microdialysis studies.
“Since the metabolite urea has been utilized as an independent measure of probe function and recovery in both human and animal brain microdialysis studies (34-37)”
From Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance (2011) · cites this paper as [36]
The paper’s main text (indexed under Abstract; page unavailable) reports using urea concentrations in human brain microdialysis samples to check the stability of catheter function. It does not describe urea use in animal studies or use urea to estimate probe recovery; it estimates Aβ recovery by in vitro experiments and zero-flow extrapolation instead. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHigher cerebral spinal fluid (CSF) levels of Aβ42 predict improved neurological recovery following severe TBI.
“While several clinical studies report that higher cerebral spinal fluid (CSF) levels of Aβ42 predict improved neurological recovery following severe TBI (139, 140)”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [139]
The Results passage in our copy (labeled Abstract; page unavailable) reports that brain interstitial-fluid Aβ rose as neurological status improved, including in TBI patients. It reports a much weaker association for ventricular CSF Aβ (r = 0.20). Although the paper measured Aβ42 in pooled samples, it does not establish that higher CSF Aβ42 predicts subsequent neurological recovery. (LLM, conf=0.88)
Experimental — accuracy not yet measuredAPP and Aβ homeostasis are exquisitely regulated processes, and bioenergetic metabolism regulates these processes.
“Overall, we feel we can confidently state APP and Aβ homeostasis are exquisitely regulated processes, and bioenergetic metabolism regulates these processes.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [177]
Soluble interstitial Aβ levels fall in the setting of trauma-induced coma, and rising levels signal clinical recovery.
“Soluble interstitial Aβ levels fall in the setting of trauma-induced coma, and rising levels signal clinical recovery [137].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [137]
Patients in coma have marked reductions in extracellular Aβ42, which rises and falls with cognitive improvement and decline.
“At first this seems difficult to reconcile with recent data showing that patients in coma have marked reductions in extracellular Aβ42, which rises and falls with cognitive improvement and decline, respectively [16].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [16]
Aβ secretion is increased with cognitive activity; in coma patients Aβ rises with cognitive improvement and declines with cognitive decline.
“Furthermore, Aβ secretion is also increased with cognitive activity, since patients in coma showed elevations in Aβ with cognitive improvement; a subsequent decline in cognitive function correlated with decline in interstitial/extracellular Aβ levels [16].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [16]
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References 30 · Cited by 295
Research works printed but not linked: 1
- [7]Johnson-Wood K Proc Natl Acad Sci USA 94 1550 1997 9037091 PMC19829
- Authors
- Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Brody, David L.
- Magnoni, Sandra
- ORCID
- Venue
- Science
- Published
- 2008-08-29
- Volume
- 321
- Issue
- 5893
- Pages
- 1221-1224
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2577829
- OpenAlex
- W2099390250
- Cited by
- 295
- References
- 30
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 15 · 2020: 16 · 2019: 11 · 2018: 15 · 2017: 24 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 19 · 2012: 27
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion)
- Funders
- National Institutes of Health (5k08ns049237-05)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341)
- National Institute of Neurological Disorders and Stroke (K08-NS049237)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- amyloid-beta, interstitial fluid, acute brain injury, neurological status, intracerebral microdialysis, neuronal activity, brain metabolism, intracranial monitoring
- MeSH terms
- Brain, Brain Injuries, Glucose, Humans, Peptide Fragments, Glasgow Coma Scale, Amyloid beta-Peptides, Microdialysis, Pyruvic Acid, Lactic Acid, Intracranial Hypertension, Extracellular Fluid
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