The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bioactive Contaminants Leach from Disposable Laboratory Plasticware
Abstract
Disposable plasticware such as test tubes, pipette tips, and multiwell assay or culture plates are used routinely in most biological research laboratories. Manufacturing of plastics requires the inclusion of numerous chemicals to enhance stability, durability, and performance. Some lubricating (slip) agents, exemplified by oleamide, also occur endogenously in humans and are biologically active, and cationic biocides are included to prevent bacterial colonization of the plastic surface. We demonstrate that these manufacturing agents leach from laboratory plasticware into a standard aqueous buffer, dimethyl sulfoxide, and methanol and can have profound effects on proteins and thus on results from bioassays of protein function. These findings have far-reaching implications for the use of disposable plasticware in biological research.
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Shotyk, W., & Krachler, M. (2007) · Environmental Science & Technology · doi:10.1021/es061511+ · Cited by 200
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Daly, R., Harrington, T. S., Martin, G. D., & Hutchings, I. M. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.03.017 · Cited by 317
Lauschke, V. M., Shafagh, R. Z., Hendriks, D. F. G., & Ingelman‐Sundberg, M. (2019) · Biotechnology Journal · doi:10.1002/biot.201800347 · Cited by 153
Zhou, Y., Shen, J. X., & Lauschke, V. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01093 · Cited by 85
Metadata
- Authors
- McDonald, G. R., Hudson, A. L., Dunn, S. M. J., You, H., Baker, G. B., Whittal, R. M., Martin, J. W., Jha, A., Edmondson, D. E., & Holt, A.
- Venue
- Science
- Published
- 2008-11-07
- Volume
- 322
- Issue
- 5903
- Pages
- 917-917
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039562024
- Cited by
- 226
- References
- 1
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- McDonald, G. R., Hudson, A. L., Dunn, S. M. J., You, H., Baker, G. B., Whittal, R. M., Martin, J. W., Jha, A., Edmondson, D. E., & Holt, A. (2008). Bioactive Contaminants Leach from Disposable Laboratory Plasticware. Science. https://doi.org/10.1126/science.1162395
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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