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Cited by 2,310Sulfur Compounds in BiologyNitric Oxide and Endothelin EffectsHeme Oxygenase-1 and Carbon Monoxide

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

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Yang, Guangdong, Wu, Lingyun, Jiang, Bo, Yang, Wei, Qi, Jiansong, Cao, Kun, Meng, Qinghe, Mustafa, Asif K., Mu, Weitong, Zhang, Shengming, Snyder, Solomon H., Wang, Rui·2008·Science
DOI 10.1126/science.1162667PMC PMC2749494
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Abstract

Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.

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  1. S. H. Zlotkin, G. H. Anderson, Pediatr. Res.16, 65 (1982).
  2. K. D. Lake-Bruseet al., Am. J. Physiol. Heart Circ. Physiol.2, H770 (1999).

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Metadata

Authors
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., Snyder, S. H., & Wang, R.
Affiliations
Johns Hopkins University (US)
Corresponding author
  • Wu, Lingyun
  • Snyder, Solomon H.
  • Wang, Rui
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2008-10-24
Volume
322
Issue
5901
Pages
587-590
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1162667
PMC
PMC2749494
OpenAlex
W2054064167
Cited by
2,310
References
27
Citations by year
2026: 37 · 2025: 84 · 2024: 89 · 2023: 104 · 2022: 135 · 2021: 148 · 2020: 151 · 2019: 162 · 2018: 145 · 2017: 169 · 2016: 163 · 2015: 188 · 2014: 173 · 2013: 147 · 2012: 134
FWCI
43.76
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R37MH018501, MH-18501)
  • National Institute on Drug Abuse (DA 00074, K05DA000074)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Keywords
hydrogen sulfide, cystathionine gamma-lyase, hypertension, vasorelaxation, endothelium-dependent relaxation, calcium/calmodulin signaling, gasotransmitters, blood pressure regulation
MeSH terms
Animals, Aorta, Blood Pressure, Calcium, Calmodulin, Cystathionine gamma-Lyase, Cysteine, Endothelium, Vascular, Homocysteine, Hydrogen Sulfide, Hypertension, Mesenteric Arteries, Myocardium, Oxidation-Reduction, Sulfides, Vasodilation, Methacholine Chloride, Mice, Knockout, Mice

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