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A Glucosinolate Metabolism Pathway in Living Plant Cells Mediates Broad-Spectrum Antifungal Defense
Open accessAbstract
Selection pressure exerted by insects and microorganisms shapes the diversity of plant secondary metabolites. We identified a metabolic pathway for glucosinolates, known insect deterrents, that differs from the pathway activated by chewing insects. This pathway is active in living plant cells, may contribute to glucosinolate turnover, and has been recruited for broad-spectrum antifungal defense responses. The Arabidopsis CYP81F2 gene encodes a P450 monooxygenase that is essential for the pathogen-induced accumulation of 4-methoxyindol-3-ylmethylglucosinolate, which in turn is activated by the atypical PEN2 myrosinase (a type of β-thioglucoside glucohydrolase) for antifungal defense. We propose that reiterated enzymatic cycles, controlling the generation of toxic molecules and their detoxification, enable the recruitment of glucosinolates in defense responses.
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Cited by
Plant immunity: towards an integrated view of plant–pathogen interactions
Dodds, P. N., & Rathjen, J. P. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2812 · Cited by 3,424
Glucosinolate Metabolites Required for an Arabidopsis Innate Immune Response
Clay, N. K., Adio, A. M., Denoux, C., Jander, G., & Ausubel, F. M. (2009) · Science · doi:10.1126/science.1164627 · Cited by 1,098
Hiruma, K., Gerlach, N., Sacristán, S., Nakano, R. T., Hacquard, S., Kracher, B., Neumann, U., Ramírez, D., Bucher, M., O’Connell, R. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.028 · Cited by 652
Self-citationBenzoxazinoid Metabolites Regulate Innate Immunity against Aphids and Fungi in Maize
Ahmad, S., Veyrat, N., Gordon-Weeks, R., Zhang, Y., Martin, J., Smart, L., Glauser, G., Erb, M., Flors, V., Frey, M., et al. (2011) · Plant Physiology · doi:10.1104/pp.111.180224 · Cited by 388
Salehin, M., Li, B., Tang, M., Katz, E., Song, L., Ecker, J. R., Kliebenstein, D. J., & Estelle, M. (2019) · Nature Communications · doi:10.1038/s41467-019-12002-1 · Cited by 311
Metadata
- Authors
- Bednarek, P., Piślewska-Bednarek, M., Svatoš, A., Schneider, B., Doubský, J., Mansurova, M., Humphry, M., Consonni, C., Panstruga, R., Sanchez-Vallet, A., Molina, A., & Schulze-Lefert, P.
- Venue
- Science
- Published
- 2009-01-02
- Volume
- 323
- Issue
- 5910
- Pages
- 101-106
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2115037790
- Cited by
- 998
- References
- 0
- FWCI
- 65.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bednarek, P., Piślewska-Bednarek, M., Svatoš, A., Schneider, B., Doubský, J., Mansurova, M., Humphry, M., Consonni, C., Panstruga, R., Sanchez-Vallet, A., Molina, A., & Schulze-Lefert, P. (2009). A Glucosinolate Metabolism Pathway in Living Plant Cells Mediates Broad-Spectrum Antifungal Defense. Science. https://doi.org/10.1126/science.1163732
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