The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease
Open accessAbstract
Hepatic glucose production is critical for basal brain function and survival when dietary glucose is unavailable. Glucose-6-phosphatase (G6Pase) is an essential, rate-limiting enzyme that serves as a terminal gatekeeper for hepatic glucose release into the plasma. Mutations in G6Pase result in Von Gierke's disease (glycogen storage disease–1a), a potentially fatal genetic disorder. We have identified the transcriptional coactivator SRC-2 as a regulator of fasting hepatic glucose release, a function that SRC-2 performs by controlling the expression of hepatic G6Pase . SRC-2 modulates G6Pase expression directly by acting as a coactivator with the orphan nuclear receptor RORα. In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production.
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St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233
Cited by
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Pyper, S. R., Viswakarma, N., Yu, S., & Reddy, J. K. (2010) · Nuclear Receptor Signaling · doi:10.1621/nrs.08002 · Cited by 379
Clocks, metabolism, and the epigenome
Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271
“One study showed that RORs recruit the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex subunit BAF60a to drive rhythmic Bmal1 and G6Pase expression (Tao et al., 2011).”
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Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Pajvani, U. B., Shawber, C. J., Samuel, V. T., Birkenfeld, A. L., Shulman, G. I., Kitajewski, J., & Accili, D. (2011) · Nature Medicine · doi:10.1038/nm.2378 · Cited by 193
Metadata
- Authors
- Chopra, A. R., Louet, J.-F., Saha, P., An, J., DeMayo, F., Xu, J., York, B., Karpen, S., Finegold, M., Moore, D., Chan, L., Newgard, C. B., & O'Malley, B. W.
- Venue
- Science
- Published
- 2008-11-28
- Volume
- 322
- Issue
- 5906
- Pages
- 1395-1399
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089735989
- Cited by
- 161
- References
- 1
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Chopra, A. R., Louet, J.-F., Saha, P., An, J., DeMayo, F., Xu, J., York, B., Karpen, S., Finegold, M., Moore, D., Chan, L., Newgard, C. B., & O'Malley, B. W. (2008). Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease. Science. https://doi.org/10.1126/science.1164847
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