The DOI matches its Crossref record; 186 of the 186 references it cites were found in a registry or an index.
New molecular insights into the mechanisms of cholestasis
Open accessAbstract
Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibility and disease progression in acquired cholestatic disorders. Cholestasis is associated with complex transcriptional and post-transcriptional alterations of hepatobiliary transporters and enzymes participating in bile formation. Ligand-activated nuclear receptors for bile acids and other biliary compounds play a key role in the regulation of genes required for bile formation. Pharmacological interventions in cholestasis may aim at modulating such novel regulatory pathways. This review will summarize the principles of molecular alterations in cholestasis and will give an overview of potential clinical implications.
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Cites
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Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
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Metadata
- Authors
- Wagner, M., Zollner, G., & Trauner, M.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 51
- Issue
- 3
- Pages
- 565-580
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1994912901
- Cited by
- 260
- References
- 186
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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