The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus
Abstract
Pannexin-1 (Px1) is expressed at postsynaptic sites in pyramidal neurons, suggesting that these hemichannels contribute to dendritic signals associated with synaptic function. We found that, in pyramidal neurons, N -methyl- d -aspartate receptor (NMDAR) activation induced a secondary prolonged current and dye flux that were blocked with a specific inhibitory peptide against Px1 hemichannels; knockdown of Px1 by RNA interference blocked the current in cultured neurons. Enhancing endogenous NMDAR activation in brain slices by removing external magnesium ions (Mg 2+ ) triggered epileptiform activity, which had decreased spike amplitude and prolonged interburst interval during application of the Px1 hemichannel blocking peptide. We conclude that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity.
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Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Nimmerjahn, A., Kirchhoff, F., Kerr, J. N. D., & Helmchen, F. (2004) · Nature Methods · doi:10.1038/nmeth706 · Cited by 784
N-Methyl-d-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease
Waxman, E. A., & Lynch, D. R. (2005) · The Neuroscientist · doi:10.1177/1073858404269012 · Cited by 372
Murphy, T. H., Li, P., Betts, K., & Liu, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5128-07.2008 · Cited by 261
Vander Jagt, T. A., Connor, J. A., & Shuttleworth, C. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5069-07.2008 · Cited by 38
Cited by
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Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120
Do astrocytes really exocytose neurotransmitters?
Hamilton, N. B., & Attwell, D. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2803 · Cited by 675
Eyo, U. B., Peng, J., Swiatkowski, P., Mukherjee, A., Bispo, A., & Wu, L.-J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0416-14.2014 · Cited by 509
Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis
Gulbransen, B. D., Bashashati, M., Hirota, S. A., Gui, X., Roberts, J. A., MacDonald, J. A., Muruve, D. A., McKay, D. M., Beck, P. L., Mawe, G. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2679 · Cited by 443
Self-citationThe P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 393
Metadata
- Authors
- Thompson, R. J., Jackson, M. F., Olah, M. E., Rungta, R. L., Hines, D. J., Beazely, M. A., MacDonald, J. F., & MacVicar, B. A.
- Venue
- Science
- Published
- 2008-12-05
- Volume
- 322
- Issue
- 5907
- Pages
- 1555-1559
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993093440
- Cited by
- 365
- References
- 4
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thompson, R. J., Jackson, M. F., Olah, M. E., Rungta, R. L., Hines, D. J., Beazely, M. A., MacDonald, J. F., & MacVicar, B. A. (2008). Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus. Science. https://doi.org/10.1126/science.1165209
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
