The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution
Open accessAbstract
Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes ( n = 99). Superimposition of capsid crystal structure and optimal-energy RNA configurations established alignments and phylogeny. These revealed conserved motifs; clade-specific diversity, including a potential newly identified species (HRV-D); mutations in field isolates; and recombination. In analogy with poliovirus, a hypervariable 5′ untranslated region tract may affect virulence. A configuration consistent with nonscanning internal ribosome entry was found in all HRVs and may account for rapid translation. The data density from complete sequences of the reference HRVs provided high resolution for this degree of modeling and serves as a platform for full genome-based epidemiologic studies and antiviral or vaccine development.
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Respiratory viruses and exacerbations of asthma in adults
Nicholson, K. G., Kent, J., & Ireland, D. C. (1993) · BMJ · doi:10.1136/bmj.307.6910.982 · Cited by 1,127
Cited by
Picornavirus and enterovirus diversity with associated human diseases
Tapparel, C., Siegrist, F., Petty, T. J., & Kaiser, L. (2013) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.10.016 · Cited by 444
Slater, L., Bartlett, N. W., Haas, J. J., Zhu, J., Message, S. D., Walton, R. P., Sykes, A., Dahdaleh, S., Clarke, D. L., Belvisi, M. G., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001178 · Cited by 317
Human Rhinovirus Species and Season of Infection Determine Illness Severity
Lee, W.-M., Lemanske, R. F., Evans, M. D., Vang, F., Pappas, T., Gangnon, R., Jackson, D. J., & Gern, J. E. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0330oc · Cited by 310
Welch, N. L., Zhu, M., Hua, C., Weller, J., Mirhashemi, M. E., Nguyen, T. G., Mantena, S., Bauer, M. R., Shaw, B. M., Ackerman, C. M., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01734-1 · Cited by 304
Edwards, M. R., Bartlett, N. W., Hussell, T., Openshaw, P., & Johnston, S. L. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2801 · Cited by 205
Metadata
- Authors
- Palmenberg, A. C., Spiro, D., Kuzmickas, R., Wang, S., Djikeng, A., Rathe, J. A., Fraser-Liggett, C. M., & Liggett, S. B.
- Venue
- Science
- Published
- 2009-04-03
- Volume
- 324
- Issue
- 5923
- Pages
- 55-59
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083623188
- Cited by
- 479
- References
- 1
- FWCI
- 27.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Palmenberg, A. C., Spiro, D., Kuzmickas, R., Wang, S., Djikeng, A., Rathe, J. A., Fraser-Liggett, C. M., & Liggett, S. B. (2009). Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution. Science. https://doi.org/10.1126/science.1165557
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