The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Human Rhinovirus Species and Season of Infection Determine Illness Severity
Open accessAbstract
RATIONALE: Human rhinoviruses (HRVs) consist of approximately 160 types that cause a wide range of clinical outcomes, including asymptomatic infections, common colds, and severe lower respiratory illnesses. OBJECTIVES: To identify factors that influence the severity of HRV illnesses. METHODS: HRV species and types were determined in 1,445 nasal lavages that were prospectively collected from 209 infants participating in a birth cohort who had at least one HRV infection. Questionnaires were used during each illness to identify moderate to severe illnesses (MSI). MEASUREMENTS AND MAIN RESULTS: Altogether, 670 HRV infections were identified, and 519 of them were solitary infections (only one HRV type). These 519 viruses belonged to 93 different types of three species: 49 A, 9 B, and 35 C types. HRV-A (odds ratio, 8.2) and HRV-C (odds ratio, 7.6) were more likely to cause MSI compared with HRV-B. In addition, HRV infections were 5- to 10-fold more likely to cause MSI in the winter months (P < 0.0001) compared with summer, in contrast to peak seasonal prevalence in spring and fall. When significant differences in host susceptibility to MSI (P = 0.004) were considered, strain-specific rates of HRV MSI ranged from less than 1% to more than 20%. CONCLUSIONS: Factors related to HRV species and type, season, and host susceptibility determine the risk of more severe HRV illness in infancy. These findings suggest that anti-HRV strategies should focus on HRV-A and -C species and identify the need for additional studies to determine mechanisms for seasonal increases of HRV severity, independent of viral prevalence, in cold weather months.
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Citations
Cites
Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
Jackson, D. J., Gangnon, R. E., Evans, M. D., Roberg, K. A., Anderson, E. L., Pappas, T. E., Printz, M. C., Lee, W.-M., Shult, P. A., Reisdorf, E., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-309oc · Cited by 1,317
Self-citationRhinovirus illnesses during infancy predict subsequent childhood wheezing
Lemanske, R. F., Jackson, D. J., Gangnon, R. E., Evans, M. D., Li, Z., Shult, P. A., Kirk, C. J., Reisdorf, E., Roberg, K. A., Anderson, E. L., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.06.024 · Cited by 735
Self-citationEpidemiology of viral respiratory infections
Monto, A. S. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)01058-0 · Cited by 557
Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution
Palmenberg, A. C., Spiro, D., Kuzmickas, R., Wang, S., Djikeng, A., Rathe, J. A., Fraser-Liggett, C. M., & Liggett, S. B. (2009) · Science · doi:10.1126/science.1165557 · Cited by 479
Vitamin D and the anti-viral state
Beard, J. A., Bearden, A., & Striker, R. (2011) · Journal of Clinical Virology · doi:10.1016/j.jcv.2010.12.006 · Cited by 423
Association between human rhinovirus C and severity of acute asthma in children
Bizzintino, J., Lee, W.-M., Laing, I. A., Vang, F., Pappas, T., Zhang, G., Martin, A. C., Khoo, S.-K., Cox, D. W., Geelhoed, G. C., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00092410 · Cited by 381
Self-citationLamson, D., Renwick, N., Kapoor, V., Liu, Z., Palacios, G., Ju, J., Dean, A., St. George, K., Briese, T., & Ian Lipkin, W. (2006) · The Journal of Infectious Diseases · doi:10.1086/508551 · Cited by 339
Lee, W.-M., Kiesner, C., Pappas, T., Lee, I., Grindle, K., Jartti, T., Jakiela, B., Lemanske, R. F., Shult, P. A., & Gern, J. E. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000966 · Cited by 310
Self-citationRhinovirus‐Associated Hospitalizations in Young Children
Miller, E. K., Lu, X., Erdman, D. D., Poehling, K. A., Zhu, Y., Griffin, M. R., Hartert, T. V., Anderson, L. J., Weinberg, G. A., Hall, C. B., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/511821 · Cited by 299
A novel group of rhinoviruses is associated with asthma hospitalizations
Miller, E. K., Edwards, K. M., Weinberg, G. A., Iwane, M. K., Griffin, M. R., Hall, C. B., Zhu, Y., Szilagyi, P. G., Morin, L.-L., Heil, L. H., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.10.007 · Cited by 264
Cited by
Teo, S. M., Mok, D., Pham, K., Kusel, M., Serralha, M., Troy, N., Holt, B. J., Hales, B. J., Walker, M. L., Hollams, E., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.008 · Cited by 953
Self-citationRole of viral infections in the development and exacerbation of asthma in children
Jartti, T., & Gern, J. E. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.003 · Cited by 474
Self-citationBeale, J., Jayaraman, A., Jackson, D. J., Macintyre, J. D. R., Edwards, M. R., Walton, R. P., Zhu, J., Ching, Y. M., Shamji, B., Edwards, M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009124 · Cited by 332
Self-citationDeMuri, G. P., Gern, J. E., Eickhoff, J. C., Lynch, S. V., & Wald, E. R. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix941 · Cited by 136
Self-citationClinical Significance of Upper Airway Virus Detection in Critically Ill Hematology Patients
Legoff, J., Zucman, N., Lemiale, V., Mokart, D., Pène, F., Lambert, J., Kouatchet, A., Demoule, A., Vincent, F., Nyunga, M., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0681oc · Cited by 80
Metadata
- Authors
- Lee, W.-M., Lemanske, R. F., Evans, M. D., Vang, F., Pappas, T., Gangnon, R., Jackson, D. J., & Gern, J. E.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-11-01
- Volume
- 186
- Issue
- 9
- Pages
- 886-891
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2116699018
- Cited by
- 310
- References
- 38
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, W.-M., Lemanske, R. F., Evans, M. D., Vang, F., Pappas, T., Gangnon, R., Jackson, D. J., & Gern, J. E. (2012). Human Rhinovirus Species and Season of Infection Determine Illness Severity. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201202-0330oc
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