The Hallucinogen N,N -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131

Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival

Hayashi, T., & Su, T.-P. (2007) · Cell · doi:10.1016/j.cell.2007.08.036 · Cited by 1,826

Trace amines: Identification of a family of mammalian G protein-coupled receptors

Borowsky, B., Adham, N., JONES, K. A., Raddatz, R., Artymyshyn, R. P., Ogozalek, K. L., Durkin, M. M., Lakhlani, P. P., Bonini, J. A., Pathirana, S. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151105198 · Cited by 912

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

Su, T., London, E. D., & Jaffe, J. H. (1988) · Science · doi:10.1126/science.2832949 · Cited by 548

The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit

Aydar, E., Palmer, C. P., Klyachko, V. A., & Jackson, M. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00677-3 · Cited by 400

??-1 Receptor Ligands

Hayashi, T., & Su, T. (2004) · CNS Drugs · doi:10.2165/00023210-200418050-00001 · Cited by 295

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

Lindemann, L., Ebeling, M., Kratochwil, N. A., Bunzow, J. R., Grandy, D. K., & Hoener, M. C. (2005) · Genomics · doi:10.1016/j.ygeno.2004.11.010 · Cited by 278

The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain

Burchett, S. A., & Hicks, T. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.003 · Cited by 227

Psychotomimetic N -Methylated Tryptamines: Formation in Brain in vivo and in vitro

Saavedra, J. M., & Axelrod, J. (1972) · Science · doi:10.1126/science.175.4028.1365 · Cited by 186

Enzymatic formation of psychotomimetic metabolites from normally occurring compounds

Axelrod, J. (1961) · Science · doi:10.1126/science.134.3475.343 · Cited by 184

Sigma Receptors and Substance Use Disorders

Sabino, V., Hicks, C., & Cottone, P. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50174-1_13 · Cited by 19

N , N -dimethyltryptamine mitigates experimental stroke by stabilizing the blood-brain barrier and reducing neuroinflammation

Laszlo, M. J., Vigh, J. P., Kocsis, A. E., Porkoláb, G., Hoyk, Z., Polgár, T. F., Walter, F. R., Szabó, A., Djurovic, S., Merkely, B. P., et al. (2025) · Science Advances · doi:10.1126/sciadv.adx5958 · Cited by 19

Differential Substitution for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate in Rats

Mori, T., Uzawa, N., Kazawa, H., Watanabe, H., Mochizuki, A., Shibasaki, M., Yoshizawa, K., Higashiyama, K., & Suzuki, T. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.214288 · Cited by 18

An Emerging Role for Sigma Receptor 1 in Personalized Treatment of Breast Cancer

Robinson, T. S., & Osman, M. A. (2023) · Cancers · doi:10.3390/cancers15133464 · Cited by 18

Effects of psychedelics on neurogenesis and broader neuroplasticity: a systematic review

da Cruz, R. V. L., Leão, R. N., & Moulin, T. C. (2024) · Molecular Medicine · doi:10.1186/s10020-024-01013-4 · Cited by 19

A biophysical approach to cancer dynamics: Quantum chaos and energy turbulence

Uthamacumaran, A. (2017) · Biosystems · doi:10.1016/j.biosystems.2017.03.004 · Cited by 20

The role of striatum and prefrontal cortex in the prevention of amphetamine-induced schizophrenia-like effects mediated by nitric oxide compounds

Issy, A. C., Pereira, M. D. S., Pedrazzi, J. F. C., Kubrusly, R. C. C., & Bel, E. A. D. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.015 · Cited by 19

Distinct Regulation of σ1 Receptor Multimerization by Its Agonists and Antagonists in Transfected Cells and Rat Liver Membranes

Hong, W. C. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.262790 · Cited by 18

Evaluation of analgesic and anti-inflammatory actions of indolealkylamines from toad venom in mice using lipidomics and molecular docking

Xu, D., Wang, J., Chen, W., Yang, X., Zhou, J., Ma, H., Di, L., & Duan, J. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113677 · Cited by 20

Phytochemistry and teratogenic potential of Mimosa tenuiflora (willd.) poir. (Fabaceae) in ruminants: A systematic review

Bezerra, J. J. L., Pinheiro, A. A. V., & Lucena, R. B. (2021) · Toxicon · doi:10.1016/j.toxicon.2021.03.010 · Cited by 18

The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes

Abdullah, C. S., Aishwarya, R., Alam, S., Remex, N. S., Morshed, M., Nitu, S. S., Miriyala, S., Panchatcharam, M., Hartman, B., King, J., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.12.002 · Cited by 18

Quantitative Analysis of Narrative Reports of Psychedelic DrugsPreprint

Coyle, J. R., Presti, D., & Baggott, M. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1206.0312 · Cited by 25

Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis

Caspani, G., Ruffell, S., Tsang, W., Netzband, N., Rohani-Shukla, C., Swann, J. R., & Jefferies, W. A. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107338 · Cited by 18

Structural Insights into Sigma1 Function

Kruse, A. C. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_95 · Cited by 18

N-Methyl-N-propyltryptamine (MPT)

Chadeayne, A. R., Golen, J. A., & Manke, D. R. (2019) · IUCrData · doi:10.1107/s2414314619009623 · Cited by 17

Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants

Torres, B., Tyler, J. S., Satyshur, K. A., & Ruoho, A. E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219664 · Cited by 17

Tryptamines

Greene, S. L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415816-0.00015-8 · Cited by 20

Salvia divinorum: A Psychopharmacological Riddle and a Mind-Body Prospect

Diaz, J.-L. (2013) · Current Drug Abuse Reviews · doi:10.2174/18744737112059990004 · Cited by 17

Synthesis and characterization of N,N-dialkyl and N-alkyl-N-aralkyl fenpropimorph-derived compounds as high affinity ligands for sigma receptors

Hajipour, A. R., Fontanilla, D., Chu, U. B., Arbabian, M. A., & Ruoho, A. E. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.04.078 · Cited by 17

Fenfluramine modulates the anti-amnesic effects induced by sigma-1 receptor agonists and neuro(active)steroids in vivo

Martin, P., Maurice, T., Gammaitoni, A. R., Farfel, G. M., Boyd, B., & Galer, B. S. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108526 · Cited by 17

Three Naturally-Occurring Psychedelics and Their Significance in the Treatment of Mental Health Disorders

Vorobyeva, N. S., & Kozlova, A. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927984 · Cited by 20

Development of sigma-1 (σ 1 ) receptor fluorescent ligands as versatile tools to study σ 1 receptors

Abate, C., Riganti, C., Pati, M. L., Ghigo, D., Berardi, F., Mavlyutov, T. A., Guo, L., & Ruoho, A. E. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.12.014 · Cited by 16

Characterization of pulmonary sigma receptors by radioligand binding

Lever, J. R., Litton, T. P., & Fergason-Cantrell, E. A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.026 · Cited by 16

Peeking into Sigma-1 Receptor Functions Through the Retina

Mavlyutov, T. A., & Guo, L. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50174-1_19 · Cited by 16

Medicinal Chemistry of σ1 Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Relationships, and Pharmacological Applications

Weber, F., & Wünsch, B. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_33 · Cited by 16

Hypotheses Regarding Ayahuasca’s Potential Mechanisms of Action in the Treatment of Addiction

Prickett, J. I., & Liester, M. B. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9_7 · Cited by 18

A Brief Review on the Potential of Psychedelics for Treating Alzheimer’s Disease and Related Depression

Pilozzi, A. R., Foster, S. L., Mischoulon, D., D, M. F. M., & Huang, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512513 · Cited by 15

Therapeutic Potential of Natural Psychoactive Drugs for Central Nervous System Disorders: A Perspective from Polypharmacology

Oña, G., & Bouso, J. C. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666191212103330 · Cited by 18

Alcaloides e o chá de ayahuasca: uma correlação dos "estados alterados da consciência" induzido por alucinógenos

de Souza, P. A. (2011) · Revista Brasileira de Plantas Medicinais · doi:10.1590/s1516-05722011000300015 · Cited by 21

Synthesis, radioiodination and in vitro and in vivo sigma receptor studies of N-1-allyl-N´-4-phenethylpiperazine analogs

Lever, S. Z., Xu, R., Fan, K.-H., Fergason-Cantrell, E. A., Carmack, T. L., Watkinson, L. D., & Lever, J. R. (2011) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2011.10.001 · Cited by 15

QEEG studies of the acute effects of the visionary tryptamine DMT.

Acosta‐Urquidi, J. (2015) · Cosmos and history · doi:10.13140/rg.2.1.4069.4248 · Cited by 14

Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatmentThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.

Fialová, K., Križanová, O., Jarkovský, J., & Novàkovâ, M. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-066 · Cited by 15

Synthesis and characterization of high‐purity N,N ‐dimethyltryptamine hemifumarate for human clinical trials

Cozzi, N. V., & Daley, P. F. (2020) · Drug Testing and Analysis · doi:10.1002/dta.2889 · Cited by 15

The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment

Sun, H., Wu, M., Wang, M., Zhang, X., & Zhu, J. Z. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1032607 · Cited by 14

Psychedelic Therapy: A Primer for Primary Care Clinicians—N,N-Dimethyltryptamine and Ayahuasca

Shinozuka, K., Tabaac, B. J., Arenas, A., Beutler, B. D., Cherian, K. N., Evans, V. D., Fasano, C., & Muir, O. S. (2024) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001725 · Cited by 15

Ethanol Exposure in Early Adolescence Inhibits Intrinsic Neuronal Plasticity via Sigma-1 Receptor Activation in Hippocampal CA1 Neurons

Sabeti, J. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01419.x · Cited by 14

The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-trisphosphate receptor in SK-N-SH cells

Gasparre, G., Abate, C., Berardi, F., & Cassano, G. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.03.021 · Cited by 14

Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel

Liu, X., Fu, Y., Yang, H. M., Mavlyutov, T. A., Li, J., McCurdy, C. R., Guo, L., & Pattnaik, B. R. (2017) · Oncotarget · doi:10.18632/oncotarget.19581 · Cited by 14

Characterization of Ligand Binding to the σ 1 Receptor in a Human Tumor Cell Line (RPMI 8226) and Establishment of a Competitive Receptor Binding Assay

Brune, S., Schepmann, D., Lehmkuhl, K., Frehland, B., & Wünsch, B. (2011) · Assay and Drug Development Technologies · doi:10.1089/adt.2011.0376 · Cited by 14

Expression of σ receptors of human urinary bladder tumor cells (RT-4 cells) and development of a competitive receptor binding assay for the determination of ligand affinity to human σ2 receptors

Schepmann, D., Lehmkuhl, K., Brune, S., & Wünsch, B. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2011.03.044 · Cited by 14

3D Homology Model of Sigma1 Receptor

Laurini, E., Marson, D., Fermeglia, M., & Pricl, S. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_35 · Cited by 14

Characterization of the synthesis of N,N‐dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry

Brandt, S. D., Moore, S. A., Freeman, S., & Kanu, A. B. (2010) · Drug Testing and Analysis · doi:10.1002/dta.142 · Cited by 14

Improved expression and purification of sigma 1 receptor fused to maltose binding protein by alteration of linker sequence

Gromek, K. A., Meddaugh, H. R., Wrobel, R. L., Suchy, F. P., Bingman, C. A., Primm, J. G., & Fox, B. G. (2013) · Protein Expression and Purification · doi:10.1016/j.pep.2013.03.013 · Cited by 13

Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands

Zampieri, D., Vio, L., Fermeglia, M., Pricl, S., Wünsch, B., Schepmann, D., Romano, M., Mamolo, M. G., & Laurini, E. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.06.001 · Cited by 13

The Alkaloids from Lophophora diffusa and Other “False Peyotes”

Chan, C. B., Poulie, C. B. M., Wismann, S. S., Soelberg, J., & Kristensen, J. L. (2021) · Journal of Natural Products · doi:10.1021/acs.jnatprod.1c00381 · Cited by 13

Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism

Li, J., Félix‐Soriano, E., Wright, K. R., Shen, H., Baer, L. A., Stanford, K. I., & Guo, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810846 · Cited by 13

Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors

Marriott, K. C., Morrison, A. Z., Moore, M., Olubajo, O., & Stewart, L. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.09.044 · Cited by 13

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E., et al. (2016) · Current Eye Research · doi:10.3109/02713683.2015.1085579 · Cited by 11

Enantioselective σ1receptor binding and biotransformation of the spirocyclic PET tracer 1′‐benzyl‐3‐(3‐fluoropropyl)‐3H‐spiro[[2]benzofuran‐1,4′‐piperidine]

Wiese, C., Maestrup, E. G., Schepmann, D., Grimme, S., Humpf, H., Brust, P., & Wünsch, B. (2010) · Chirality · doi:10.1002/chir.20893 · Cited by 13

The sigma-1 receptor: a molecular chaperone for the heart and the soul?

Ehmke, H. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr313 · Cited by 13

Primum non nocere: The onus to characterize the potential harms of psychedelic treatment

Ghaznavi, S., Ruskin, J. N., Haggerty, S. J., King, F., & Rosenbaum, J. F. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230914 · Cited by 12

Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye

Szilágyi, A., Takács, B., Szekeres, R., Tarjányi, V., Bombicz, M., Priksz, D., Kovacs, A. I., Juhász, B., Frecska, E., Szilvássy, Z., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10050997 · Cited by 13

Nonopioid effect of β-endorphin

Kovalitskaya, Y. A., & Navolotskaya, E. V. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911040018 · Cited by 12

Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease

Ma, W., Chen, A.-F., Xie, X., & Huang, Y. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108342 · Cited by 12

Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening

Dvorácskó, S., Lázár, L., Fülöp, F., Palkó, M., Zalán, Z., Penke, B., Fülöp, L., Tömböly, C., & Bogár, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158112 · Cited by 12

Molecular and structural insights into the 5‐HT 2C receptor as a therapeutic target for substance use disorders

Ubhayarathna, M., Langmead, C. J., Diepenhorst, N. A., & Stewart, G. D. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16233 · Cited by 12

Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety

Bergkemper, M., Kronenberg, E., Thum, S., Börgel, F., Daniliuc, C. G., Schepmann, D., Nieto, F. R., Brust, P., Reinoso, R. F., Álvarez, I., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01183 · Cited by 12

Long-lasting analgesic effect of the psychedelic drug changa: A case report

Oña, G., & Troncoso, S. (2019) · Journal of Psychedelic Studies · doi:10.1556/2054.2019.001 · Cited by 12

Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke

Ngo, A., Fattakhov, N. S., & Toborek, M. J. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241281547 · Cited by 11

Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics

Chaves, C., SANTOS, R. G. D., Dursun, S. M., Tusconi, M., Carta, M. G., Brietzke, E. M., & Hallak, J. E. C. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1485337 · Cited by 11

Plant-derived compounds and neurodegenerative diseases: Different mechanisms of action with therapeutic potential

Echeverry, C., Pazos, M., Torres‐Pérez, M., & Prunell, G. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.12.039 · Cited by 12

Binding of synthetic peptide TPLVTLFK to nonopioid beta‐endorphin receptor on rat brain membranes

Nekrasova, Y. N., Sadovnikov, V. B., Zolotarev, Y. A., & Navolotskaya, E. V. (2010) · Journal of Peptide Science · doi:10.1002/psc.1231 · Cited by 11

Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy

Song, T., Zhao, J., Ma, X., Zhang, Z., Jiang, B., & Yang, Y. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0117 · Cited by 11

Advances with the discovery and development of novel sigma 1 receptor antagonists for the management of pain

Burns, M., Guadagnoli, N., & McCurdy, C. R. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2216015 · Cited by 11

The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma

Mysona, B. A., Kansara, N., Zhao, J., & Bollinger, K. E. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50174-1_20 · Cited by 12

From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design

Yu, L.-F., Zhang, H.-K., Gunosewoyo, H., & Kozikowski, A. P. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml3002715 · Cited by 11

Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats

Yoshizawa, K., Mori, T., Ueno, T., Nishiwaki, M., Shibasaki, M., Shimizu, N., Narita, M., & Suzuki, T. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12148sc · Cited by 11

Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands

Zampieri, D., Laurini, E., Vio, L., Golob, S., Fermeglia, M., Pricl, S., & Mamolo, M. G. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.01.032 · Cited by 11

Sigma 1 Receptor Chaperone: Pharmacology and Therapeutic Perspectives

Zamanillo, D., Portillo-Salido, E. F., Vela, J. M., & Romero, L. I. (2012) · doi:10.1002/9781118185537.ch6 · Cited by 11

Recent advances in drug discovery efforts targeting the sigma 1 receptor system: Implications for novel medications designed to reduce excessive drug and food seeking

Knowles, L. G., Armanious, A. J., Peng, Y., Welsh, W. J., & James, M. H. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100126 · Cited by 10

Neural Plasticity in the Ventral Tegmental Area, Aversive Motivation during Drug Withdrawal and Hallucinogenic Therapy

Vargas-Pérez, H., Grieder, T. E., & van der Kooy, D. (2022) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2022.2033889 · Cited by 10

Synthesis and characterization of 5‐methoxy‐2‐methyl‐N,N‐dialkylated tryptamines

Brandt, S. D., Tearavarich, R., Dempster, N. M., Cozzi, N. V., & Daley, P. F. (2012) · Drug Testing and Analysis · doi:10.1002/dta.398 · Cited by 10

Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor–receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels

Romero‐Fernandez, W., Zhou, Z., Beggiato, S., Wydra, K., Filip, M., Tanganelli, S., Borroto‐Escuela, D. O., Ferraro, L., & Fuxé, K. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00069-3 · Cited by 10

Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity

Bechthold, E., Schreiber, J. A., Ritter, N., Grey, L., Schepmann, D., Daniliuc, C. G., González‐Cano, R., Nieto, F. R., Seebohm, G., & Wünsch, B. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114113 · Cited by 10

Investigations into the polymorphic properties of N,N-dimethyltryptamine by X-ray diffraction and differential scanning calorimetry

Gaujac, A., Ford, J. L., Dempster, N. M., de Andrade, J. B., & Brandt, S. D. (2013) · Microchemical Journal · doi:10.1016/j.microc.2013.03.009 · Cited by 10

Microwave‐accelerated preparation and analytical characterization of 5‐ethoxy‐N,N‐dialkyl‐[α,α,β,β‐H4]‐ and [α,α,β,β‐D4]‐tryptamines

Tearavarich, R., Hahnvajanawong, V., Dempster, N. M., Daley, P. F., Cozzi, N. V., & Brandt, S. D. (2010) · Drug Testing and Analysis · doi:10.1002/dta.223 · Cited by 10

Discovery and In Vitro Characterization of SPL028: Deuterated N , N -Dimethyltryptamine

Layzell, M., Rands, P., Good, M., Joel, Z., Cousins, R. P. C., Benway, T. A., James, E., & Routledge, C. A. (2023) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.3c00143 · Cited by 9

Hypothetical biosynthetic pathways of pharmaceutically potential hallucinogenic metabolites in Myristicaceae, mechanistic convergence and co-evolutionary trends in plants and humans

Barman, R., Bora, P. K., Saikia, J., Konwar, P., Sarkar, A., Kemprai, P., Saikia, S. P., Haldar, S., Slater, R. J., & Banik, D. (2023) · Phytochemistry · doi:10.1016/j.phytochem.2023.113928 · Cited by 9

The Clinical Potential of Dimethyltryptamine: Breakthroughs into the Other Side of Mental Illness, Neurodegeneration, and Consciousness

Colosimo, F. A., Borsellino, P., Krider, R. I., Márquez, R., & Vida, T. A. (2024) · Psychoactives · doi:10.3390/psychoactives3010007 · Cited by 11

Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons

Petrušková, A., Guhathakurta, D., Akdaş, E. Y., Perelló‐Amorós, B., Frischknecht, R., Weiss, E., Páleníček, T., & Fejtová, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70020 · Cited by 11

Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation

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