Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival

σ-1 Receptors (σ1 Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export

Hayashi, T., & Su, T.-P. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051284 · Cited by 262 · see citing works

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., & Walter, P. (2009) · Science · doi:10.1126/science.1175088 · Cited by 1,275 · see citing works

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

Wieckowski, M. R., Giorgi, C., Lebiedzinska, M., Duszynski, J., & Pinton, P. (2009) · Nature Protocols · doi:10.1038/nprot.2009.151 · Cited by 979 · see citing works

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723 · see citing works

The pharmacology of sigma-1 receptors.

Maurice, T., & Su, T.-P. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.07.001 · Cited by 654 · see citing works

Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions

Csordás, G., Weaver, D., & Hajnóczky, G. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.009 · Cited by 625 · see citing works

The Hallucinogen <i>N,N</i> -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

Fontanilla, D., Johannessen, M., Hajipour, A. R., Cozzi, N. V., Jackson, M. B., & Ruoho, A. E. (2009) · Science · doi:10.1126/science.1166127 · Cited by 535 · see citing works

Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models

Hedskog, L., Pinho, C. M., Filadi, R., Rönnbäck, A., Hertwig, L., Wiehager, B., Larssen, P., Gellhaar, S., Sandebring, A., Westerlund, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300677110 · Cited by 478 · see citing works

Crystal structure of the human σ1 receptor

Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., & Kruse, A. C. (2016) · Nature · doi:10.1038/nature17391 · Cited by 482 · see citing works

Organization and Function of Membrane Contact Sites

Helle, S. C. J., Kanfer, G., Kolar, K., Lang, A., Michel, A. H., & Kornmann, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.01.028 · Cited by 453 · see citing works

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Dang, E. V., McDonald, J. G., Russell, D. W., & Cyster, J. G. (2017) · Cell · doi:10.1016/j.cell.2017.09.029 · Cited by 348 · see citing works

Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.

Mori, T., Hayashi, T., Hayashi, E., & Su, T.-P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076941 · Cited by 317 · see citing works

MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2

Sugiura, A., Nagashima, S., Tokuyama, T., Amo, T., Matsuki, Y., Ishido, S., Kudo, Y., McBride, H. M., Fukuda, T., Matsushita, N., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.04.023 · Cited by 303 · see citing works

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.

de Vos, C. M. H., Mason, N. L., & Kuypers, K. P. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.724606 · Cited by 269 · see citing works

Neuropharmacology of N,N-dimethyltryptamine

Carbonaro, T. M., & Gatch, M. B. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.016 · Cited by 268 · see citing works

Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death

Calvo-Rodriguez, M., & Bacskai, B. J. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.004 · Cited by 254 · see citing works

The sigma-1 receptor: roles in neuronal plasticity and disease

Kourrich, S., Su, T.-P., Fujimoto, M., & Bonci, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.09.007 · Cited by 245 · see citing works

The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization

Frecska, E., Bokor, P., & Winkelman, M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00035 · Cited by 242 · see citing works

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

Szabo, A., Kovacs, A., Frecska, E., & Rajnavolgyi, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106533 · Cited by 191 · see citing works

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.

Pal, A., Fontanilla, D., Gopalakrishnan, A., Chae, Y.-K., Markley, J. L., & Ruoho, A. E. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.01.030 · Cited by 177 · see citing works

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

Wu, B., Zhao, T. V., Jin, K., Hu, Z., Abdel, M. P., Warrington, K. J., Goronzy, J. J., & Weyand, C. M. (2021) · Nature Immunology · doi:10.1038/s41590-021-01065-2 · Cited by 141 · see citing works

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma ₁ (σ ₁ ) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative

Villard, V., Espallergues, J., Keller, E., Vamvakides, A., & Maurice, T. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110379286 · Cited by 139 · see citing works

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

Liu, Y., & Zhu, X. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0092-6 · Cited by 132 · see citing works

The roles of mitochondria in global and local intracellular calcium signalling

Cartes-Saavedra, B., Ghosh, A., & Hajnóczky, G. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00820-1 · Cited by 126 · see citing works

The endogenous hallucinogen and trace amine N.N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

Szabo, A., Kovacs, A., Riba, J., Djurovic, S., Rajnavolgyi, E., & Frecska, E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00423 · Cited by 121 · see citing works

A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity.

Frecska, E., Szabo, A., Winkelman, M. J., Luna, L. E., & McKenna, D. J. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1024-y · Cited by 109 · see citing works

Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death

Gutiérrez, T., & Simmen, T. (2018) · Cell Calcium · doi:10.1016/j.ceca.2017.05.015 · Cited by 104 · see citing works

Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan

Nguyen, L., Robson, M. J., Healy, J. R., Scandinaro, A. L., & Matsumoto, R. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089985 · Cited by 99 · see citing works

Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

Inserra, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00330 · Cited by 91 · see citing works

Conversion of psychological stress into cellular stress response: Roles of the sigma‐1 receptor in the process

Hayashi, T. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12262 · Cited by 87 · see citing works

σ-1 receptor at the mitochondrial-associated endoplasmic reticulum membrane is responsible for mitochondrial metabolic regulation

Marriott, K.-S. C., Prasad, M., Thapliyal, V., & Bose, H. S. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.198168 · Cited by 75 · see citing works

Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival

Lewis, A., Hayashi, T., Su, T.-P., & Betenbaugh, M. J. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-013-9527-7 · Cited by 66 · see citing works

Sigma-1 Receptor Expression in Sensory Neurons and the Effect of Painful Peripheral Nerve Injury

Bangaru, M. L., Weihrauch, D., Tang, Q.-B., Zoga, V., Hogan, Q., & Wu, H.-E. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-47 · Cited by 62 · see citing works

Sigma-1 receptor: a potential therapeutic target for traumatic brain injury

Shi, M., Chen, F., Chen, Z., Yang, W., Yue, S., Zhang, J., & Chen, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.685201 · Cited by 58 · see citing works

Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure

Gong, Y., Lin, J., Ma, Z., Yu, M., Wang, M., Lai, D., & Fu, G. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119511 · Cited by 58 · see citing works

Asbestos-induced Disruption of Calcium Homeostasis Induces Endoplasmic Reticulum Stress in Macrophages

Ryan, A. J., Larson-Casey, J. L., He, C., Murthy, S., & Carter, A. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579870 · Cited by 43 · see citing works

Rifampicin Decreases Neuroinflammation to Maintain Mitochondrial Function and Calcium Homeostasis in Rotenone-Treated Zebrafish

Yurtsever, İ., Üstündağ, Ü. V., Ünal, İ., Ateş, P. S., & Emekli-Alturfan, E. (2022) · Drug and Chemical Toxicology · doi:10.1080/01480545.2020.1846549 · Cited by 39 · see citing works

The sigma-1 receptor at the crossroad of proteostasis, neurodegeneration, and autophagy

Christ, M. G., Clement, A. M., & Behl, C. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2019.12.002 · Cited by 36 · see citing works

Neuroprotective substances: Are they able to protect the pancreatic beta-cells too?

Ostrovskaya, R. U., & Ivanov, S. V. (2022) · Endocrine, Metabolic &amp; Immune Disorders - Drug Targets · doi:10.2174/1871530322666220303162844 · Cited by 13 · see citing works

The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants

Xiao, N., Yin, L., Teopiz, K. M., Kwan, A. T. H., Le, G. H., Wong, S., Valentino, K., Choi, H., Rosenblat, J. D., Ho, R., et al. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2500424 · Cited by 6 · see citing works

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Bai, P., Gomm, A., Yoo, C., Mondal, P., Lobo, F. M., Meng, H., Zhou, Y., Xie, W., Wey, H., Tanzi, R. E., et al. (2025) · Advanced Science · doi:10.1002/advs.202414827 · Cited by 5 · see citing works