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Extensive Demethylation of Repetitive Elements During Seed Development Underlies Gene Imprinting
Open accessAbstract
Dynamic Imprinting: Gene imprinting—the silencing of either a maternally derived or paternally derived gene allele—is controlled in large part by DNA methylation. In plants, imprinting occurs in the endosperm, which nourishes the embryonic plant. Gehring et al. (p. 1447 ) and Hsieh et al. (p. 1451 ) analyzed the dynamics of DNA methylation in the endosperm and embryo of Arabidopsis and found extensive demethylation in the endosperm, suggesting that many imprinted genes are likely to exist. Gehring et al. characterized five imprinted genes in detail. Four of the 10 known imprinted genes are related homeodomain transcription factors. Furthermore, 5′ sequences demethylated in several of the genes were found to be derived from transposable elements, which supports the idea that imprinting arose as a by-product of silencing invading DNA.
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Citations
Cites
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
Cited by
Transgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864
Transposable Elements, Epigenetics, and Genome Evolution
Fedoroff, N. V. (2012) · Science · doi:10.1126/science.338.6108.758 · Cited by 634
Regulation and function of DNA methylation in plants and animals
He, X.-J., Chen, T., & Zhu, J.-K. (2011) · Cell Research · doi:10.1038/cr.2011.23 · Cited by 555
Local DNA hypomethylation activates genes in rice endosperm
Zemach, A., Kim, M. Y., Silva, P., Rodrigues, J. A., Dotson, B., Brooks, M. D., & Zilberman, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009695107 · Cited by 384
A DEMETER-like DNA demethylase governs tomato fruit ripening
Liu, R., How-Kit, A., Stammitti, L., Teyssier, E., Rolin, D., Mortain-Bertrand, A., Halle, S., Liu, M., Kong, J., Wu, C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503362112 · Cited by 371
Metadata
- Authors
- Gehring, M., Bubb, K. L., & Henikoff, S.
- Venue
- Science
- Published
- 2009-06-12
- Volume
- 324
- Issue
- 5933
- Pages
- 1447-1451
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1586021010
- Cited by
- 571
- References
- 1
- FWCI
- 33.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Gehring, M., Bubb, K. L., & Henikoff, S. (2009). Extensive Demethylation of Repetitive Elements During Seed Development Underlies Gene Imprinting. Science. https://doi.org/10.1126/science.1171609
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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