Transposable Elements, Epigenetics, and Genome Evolution
Abstract
Transposable genetic elements (TEs) comprise a vast array of DNA sequences, all having the ability to move to new sites in genomes either directly by a cut-and-paste mechanism (transposons) or indirectly through an RNA intermediate (retrotransposons). First discovered in maize plants by the
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Constitutive heterochromatin is a silencing mechanism for transposable elements.
“Based on previous studies that identified constitutive heterochromatin as a silencing mechanism for transposable elements35, we next determined if genetically promoting heterochromatin relaxation affects the transposable elements that are differentially expressed in tau transgenic Drosophila.”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [35]
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Linking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · see citing works
Horizontal Transfer, Not Duplication, Drives the Expansion of Protein Families in Prokaryotes
Treangen, T. J., & Rocha, E. P. C. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001284 · Cited by 509 · see citing works
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A Field Guide to Eukaryotic Transposable Elements
Wells, J. N., & Feschotte, C. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-040620-022145 · Cited by 686 · see citing works
Sun, W., Samimi, H., Gamez, M., Zare, H., & Frost, B. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0194-1 · Cited by 315 · see citing works
Epigenetic patterns in a complete human genome
Gershman, A., Sauria, M. E. G., Guitart, X., Vollger, M. R., Hook, P. W., Hoyt, S. J., Jain, M., Shumate, A., Razaghi, R., Koren, S., et al. (2022) · Science · doi:10.1126/science.abj5089 · Cited by 297 · see citing works
A heterochromatin-dependent transcription machinery drives piRNA expression
Andersen, P. R., Tirian, L., Vunjak, M., & Brennecke, J. (2017) · Nature · doi:10.1038/nature23482 · Cited by 280 · see citing works
The functional basis of adaptive evolution in chemostats
Gresham, D., & Hong, J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12082 · Cited by 122 · see citing works
Bulut-Karslioglu, A., Macrae, T. A., Oses-Prieto, J. A., Covarrubias, S., Percharde, M., Ku, G., Diaz, A., McManus, M. T., Burlingame, A. L., & Ramalho-Santos, M. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.004 · Cited by 97 · see citing works
Gimenez, M. D., Yañez-Santos, A. M., Paz, R. C., Quiroga, M. P., Marfil, C. F., Conci, V. C., & García-Lampasona, S. C. (2016) · Plant Cell Reports · doi:10.1007/s00299-015-1874-x · Cited by 47 · see citing works
- Authors
- Fedoroff, N. V.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Fedoroff, Nina V.
- ORCID
- Fedoroff, Nina V.
- Venue
- Science
- Published
- 2012-11-09
- Volume
- 338
- Issue
- 6108
- Pages
- 758-767
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064155145
- Cited by
- 634
- References
- 2
- Citations by year
- 2026: 39 · 2025: 38 · 2024: 43 · 2023: 64 · 2022: 48 · 2021: 53 · 2020: 47 · 2019: 37 · 2018: 38 · 2017: 40 · 2016: 50 · 2015: 53 · 2014: 50 · 2013: 31 · 2012: 2
- FWCI
- 49.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- transposable elements, epigenetics, genome evolution, retrotransposons, cut-and-paste transposition, RNA intermediate, transposon mobility
- MeSH terms
- Animals, DNA Transposable Elements, Humans, Plants, Regulatory Sequences, Nucleic Acid, Repetitive Sequences, Nucleic Acid, Genome, Retroelements, Genome, Plant, Evolution, Molecular, DNA Methylation, Gene Silencing, DNA, Intergenic, Epigenesis, Genetic
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