The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Motile Cilia of Human Airway Epithelia Are Chemosensory
Open accessAbstract
Beat It: Primary cilia are specialized organelles that serve important sensory functions in many different tissues and cells, and defects in their structure and function underlie a variety of genetic diseases. In contrast to primary cilia, motile cilia serve a mechanical function. For example, the cilia on airway epithelia remove inhaled material from the lung. Shah et al. (p. 1131 , published online 23 July; see the cover; see the Perspective by Kinnamon and Reynolds ) now show that these classic motile cilia are also chemosensory. The motile cilia on airway epithelia contain bitter-taste receptors and their associated signaling machinery. Moreover, application of bitter substances triggers an elevation of intracellular Ca 2+ levels and increases cilia beat frequency. Thus, in airway epithelia, bitter-taste receptors may be able to detect noxious substances entering the airways and initiate an autonomous defensive mechanism designed to accelerate elimination of the offending compound.
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The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
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Cilia and Mucociliary Clearance
Bustamante-Marin, X. M., & Ostrowski, L. E. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028241 · Cited by 830
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Peyer, K. E., Zhang, L., & Nelson, B. J. (2013) · Nanoscale · doi:10.1039/c2nr32554c · Cited by 820
The functions of human saliva: A review sponsored by the World Workshop on Oral Medicine VI
Dawes, C., Pedersen, A. M. L., Villa, A., Ekström, J., Proctor, G. B., Vissink, A., Aframian, D., McGowan, R., Aliko, A., Narayana, N., et al. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2015.03.004 · Cited by 572
Wallmeier, J., Nielsen, K. G., Kuehni, C. E., Lucas, J. S., Leigh, M. W., Zariwala, M. A., & Omran, H. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0209-6 · Cited by 403
The development and functions of multiciliated epithelia
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Metadata
- Authors
- Shah, A. S., Ben-Shahar, Y., Moninger, T. O., Kline, J. N., & Welsh, M. J.
- Venue
- Science
- Published
- 2009-08-28
- Volume
- 325
- Issue
- 5944
- Pages
- 1131-1134
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2144827439
- Cited by
- 717
- References
- 2
- FWCI
- 25.66
- Type
- journal article
- Language
- en
- Open access
- green
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