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DICER1 Mutations in Familial Pleuropulmonary Blastoma

Hill, D. Ashley, Ivanovich, Jennifer, Priest, John R., Gurnett, Christina A., Dehner, Louis P., Desruisseau, David, Jarzembowski, Jason A., Wikenheiser-Brokamp, Kathryn A. +6 more·2009·Science
DOI 10.1126/science.1174334PMC PMC3098036
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Abstract

A rare form of lung cancer in children is associated with mutational disruption of an enzyme that generates small noncoding RNAs.

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Crossref · 10.1126/science.1174334

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  • DICER1 knockouts are known to significantly repress 3p driver microRNA levels while allowing for longer 5p microRNAs that are loaded into Ago and trimmed back from the 3p end.

    “DICER1 knockouts are known to significantly repress 3p driver microRNA levels while allowing for longer 5p microRNAs that are loaded into Ago and trimmed back from the 3p end (Hill et al. 2009).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Hill et al. 2009

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Cites

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Research works printed but not linked: 6

  1. [1]Hill DA Am. J. Surg. Pathol 2008 32 282 18223332
  2. [2]Priest JR Cancer 1997 80 147 9210721
  3. [3]Priest JR J. Pediatr 1996 128 220 8636815
  4. [5]Bartel DP Cell 2004 116 281 14744438
  5. [6]Harris KS Zhang Z McManus MT Harfe BD Sun X Proc. Natl. Acad. Sci. U. S. A 2006 103 2208 16452165 PMC1413733
  6. [7]Morita S PLOS One 2009 4 e4212 19148298 PMC2621087

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Authors
Hill, D. A., Ivanovich, J., Priest, J. R., Gurnett, C. A., Dehner, L. P., Desruisseau, D., Jarzembowski, J. A., Wikenheiser-Brokamp, K. A., Suarez, B. K., Whelan, A. J., Williams, G., Bracamontes, D., Messinger, Y., & Goodfellow, P. J.
Affiliations
  • Washington University Medical Center, St. Louis, MO 63110, USA.
  • The International Pleuropulmonary Blastoma Registry, Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN 55404, USA.
  • Children’s Hospital of Wisconsin, Milwaukee, WI 53201, USA.
  • Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2009-08-21
Volume
325
Issue
5943
Pages
965-965
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1174334
PMC
PMC3098036
Cited by
682
References
0
Language
en

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