MicroRNAs in the p53 network: micromanagement of tumour suppression
Abstract
In recent years, microRNAs (miRNAs) have been identified as mediators of tumour suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated miRNAs contribute to tumour suppression by controlling the expression of central components of multiple processes, including cell cycle progression, epithelial-mesenchymal transition, stemness, metabolism, cell survival and angiogenesis. The expression and activity of p53 itself is also under the control of miRNAs. Finally, genetic and epigenetic alterations identified in the p53-miRNA network indicate that these pathways are important for the initiation and progression of tumours. In the future, knowledge about the p53-miRNA network may be able to be exploited for diagnostic and therapeutic approaches in cancer prevention and treatment.
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Several noncoding RNAs, including microRNAs and long noncoding RNAs such as TUG1, miR-34, lincRNA-p21, PANDA and PINT, were reported to mediate p53-dependent gene regulation.
“Several noncoding RNAs were reported to mediate p53-dependent gene regulation—these include microRNAs120 and long noncoding RNAs,121 such as TUG1,122, 123 miR-34,124 lincRNA-p21,125 PANDA126 and PINT.127”
From Census and evaluation of p53 target genes (2017) · cites this paper as [120]
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2 retracted
Pichiorri, F., Suh, S.-S., Rocci, A., De Luca, L., Taccioli, C., Santhanam, R., Zhou, W., Benson, D. M., Hofmainster, C., Alder, H., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.09.005 · Cited by 436 · see citing works
RetractedA TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Melo, S. A., Ropero, S., Moutinho, C., Aaltonen, L. A., Yamamoto, H., Calin, G. A., Rossi, S., Fernández, A. F., Carneiro, F., Oliveíra, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.317 · Cited by 375 · see citing works
RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,497 · see citing works
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262 · see citing works
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 4,269 · see citing works
Tumor Metastasis: Molecular Insights and Evolving Paradigms
Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011 · see citing works
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852 · see citing works
miR-15 and miR-16 induce apoptosis by targeting BCL2
Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M., Shimizu, M., Wojcik, S. E., Aqeilan, R. I., Zupo, S., Dono, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506654102 · Cited by 3,510 · see citing works
Otto Warburg's contributions to current concepts of cancer metabolism
Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427 · see citing works
Regulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214 · see citing works
A decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871 · see citing works
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works
A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
Calin, G. A., Ferracin, M., Cimmino, A., Leva, G. D., Shimizu, M., Wojcik, S. E., Iorio, M. V., Visone, R., Sever, N. İ., Fabbri, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050995 · Cited by 2,403 · see citing works
Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272 · see citing works
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010 · see citing works
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works
The epigenetic progenitor origin of human cancer
Feinberg, A. P., OHLSSON, R. I., & Henikoff, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1748 · Cited by 1,851 · see citing works
Burk, U., Schubert, J., Wellner, U. F., Schmalhofer, O., Vincan, E., Spaderna, S., & Brabletz, T. (2008) · EMBO Reports · doi:10.1038/embor.2008.74 · Cited by 1,722 · see citing works
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Wellner, U. F., Schubert, J., Burk, U., Schmalhofer, O., Zhu, F., Sonntag, A., Waldvogel, B., Vannier, C., Darling, D. S., Hausen, A. Z., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1998 · Cited by 1,686 · see citing works
MicroRNAs in Stress Signaling and Human Disease
Mendell, J. T., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.02.005 · Cited by 1,673 · see citing works
Korpal, M., Lee, E. S., Hu, G., & Kang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800074200 · Cited by 1,642 · see citing works
Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635 · see citing works
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works
Kruse, J.-P., & Gu, W. (2009) · Cell · doi:10.1016/j.cell.2009.04.050 · Cited by 1,610 · see citing works
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564 · see citing works
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Liu, C., Kelnar, K., Liu, B., Chen, X., Calhoun‐Davis, T., Li, H., Patrawala, L., Yan, H., Jeter, C. R., Honorio, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2284 · Cited by 1,401 · see citing works
Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis
Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N. B.-C., Bentwich, Z., & Oren, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.017 · Cited by 1,352 · see citing works
miR-34a repression of SIRT1 regulates apoptosis
Yamakuchi, M., Ferlito, M., & Lowenstein, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801613105 · Cited by 1,344 · see citing works
The miR-34 family in cancer and apoptosis
Hermeking, H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.56 · Cited by 1,236 · see citing works
Self-citationDownregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
Shimono, Y., Zabala, M., Cho, R. W., Lobo, N. A., Dalerba, P. D., Qian, D., Diehn, M., Liu, H., Panula, S., Chiao, E. T., et al. (2009) · Cell · doi:10.1016/j.cell.2009.07.011 · Cited by 1,205 · see citing works
MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156 · see citing works
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
Xu, N., Papagiannakopoulos, T. Y., Pan, G., Thomson, J. A., & Kosik, K. S. (2009) · Cell · doi:10.1016/j.cell.2009.02.038 · Cited by 1,128 · see citing works
Modulation of microRNA processing by p53
Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., & Miyazono, K. (2009) · Nature · doi:10.1038/nature08199 · Cited by 1,125 · see citing works
p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
Bommer, G. T., Gerin, I., Feng, Y., Kaczorowski, A. J., Kuick, R. D., Love, R. E., Zhai, Y., Giordano, T. J., Qin, Z. S., Moore, B. B., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.068 · Cited by 1,122 · see citing works
Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation
Mayr, C., Hemann, M. T., & Bartel, D. P. (2007) · Science · doi:10.1126/science.1137999 · Cited by 1,099 · see citing works
Lujambio, A., & Lowe, S. W. (2012) · Nature · doi:10.1038/nature10888 · Cited by 1,084 · see citing works
A microRNA DNA methylation signature for human cancer metastasis
Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez‐Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803055105 · Cited by 1,078 · see citing works
Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
Tay, Y., Kats, L. M., Salmena, L., Weiss, D., Tan, S. M., Ala, U., Karreth, F. A., Poliseno, L., Provero, P., Cunto, F. D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.029 · Cited by 1,011 · see citing works
The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
Bonci, D., Coppola, V., Musumeci, M., Addario, A., Giuffrida, R., Memeo, L., D’Urso, L., Pagliuca, A., Biffoni, M., Labbaye, C., et al. (2008) · Nature Medicine · doi:10.1038/nm.1880 · Cited by 989 · see citing works
Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959 · see citing works
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
Kasinski, A. L., & Slack, F. J. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3166 · Cited by 934 · see citing works
Tarasov, V., Jung, P., Verdoodt, B., Lodygin, D., Epanchintsev, A., Menssen, A., Meister, G., & Hermeking, H. (2007) · Cell Cycle · doi:10.4161/cc.6.13.4436 · Cited by 922 · see citing works
Self-citationTumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., & Gu, W. (2012) · Cell · doi:10.1016/j.cell.2012.04.026 · Cited by 912 · see citing works
The Lin28/let-7 axis regulates glucose metabolism
Zhu, H., Shyh-Chang, N., Segrè, A., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J., Kharas, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.033 · Cited by 907 · see citing works
Snail blocks the cell cycle and confers resistance to cell deathPreprint
Vega, S., Morales, A. V., Ocaña, O. H., Valdés, F., Fabregat, I., & Nieto, M. A. (2004) · Genes & Development · doi:10.1101/gad.294104 · Cited by 866 · see citing works
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
DeBerardinis, R. J., & Thompson, C. B. (2012) · Cell · doi:10.1016/j.cell.2012.02.032 · Cited by 858 · see citing works
Klein, U., Lia, M., Crespo, M., Siegel, R., Shen, Q. “., Mo, T., Ambesi‐Impiombato, A., Califano, A., Migliazza, A., Bhagat, G., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.019 · Cited by 851 · see citing works
p53 represses c-Myc through induction of the tumor suppressor miR-145
Sachdeva, M., Zhu, S., Wu, F., Wu, H., Walia, V., Kumar, S. R., Elble, R. C., Watabe, K., & Mo, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808042106 · Cited by 841 · see citing works
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
Welch, C., Chen, Y., & Stallings, R. L. (2007) · Oncogene · doi:10.1038/sj.onc.1210293 · Cited by 805 · see citing works
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
Lodygin, D., Tarasov, V., Epanchintsev, A., Berking, C., Knyazeva, T., Koerner, H., Knyazev, P. G., Diebold, J., & Hermeking, H. (2008) · Cell Cycle · doi:10.4161/cc.7.16.6533 · Cited by 784 · see citing works
Self-citationMicroRNA functions in stress responses
Leung, A. K. L., & Sharp, P. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.027 · Cited by 765 · see citing works
Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
Wong, T., Liu, X., Wong, B. Y., Ng, R. W. M., Yuen, A. P. W., & Wei, W. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0666 · Cited by 750 · see citing works
p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs
Chang, C.-J., Chao, C.-H., Xia, W., Yang, J.-Y., Xiong, Y., Li, C., Yu, W.-H., Rehman, S. K., Hsu, J. L., Lee, H., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2173 · Cited by 745 · see citing works
p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis
Vaseva, A. V., Marchenko, N. D., Ji, K., Tsirka, S. E., Holzmann, S., & Moll, U. M. (2012) · Cell · doi:10.1016/j.cell.2012.05.014 · Cited by 740 · see citing works
Mediation of c-Myc-Induced Apoptosis by p53
Hermeking, H., & Eick, D. (1994) · Science · doi:10.1126/science.8091232 · Cited by 738 · see citing works
Self-citationDicer, Drosha, and Outcomes in Patients with Ovarian Cancer
Merritt, W. M., Lin, Y. G., Han, L. Y., Kamat, A. A., Spannuth, W. A., Schmandt, R. E., Urbauer, D. L., Pennacchio, L. A., Cheng, J., Nick, A. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0803785 · Cited by 710 · see citing works
MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells
Ji, Q., Hao, X., Zhang, M., Tang, W., Yang, M., Li, L., Xiang, D., DeSano, J. T., Bommer, G. T., Fan, D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006816 · Cited by 691 · see citing works
<i>DICER1</i> Mutations in Familial Pleuropulmonary Blastoma
Hill, D. A., Ivanovich, J., Priest, J. R., Gurnett, C. A., Dehner, L. P., Desruisseau, D., Jarzembowski, J. A., Wikenheiser-Brokamp, K. A., Suarez, B. K., Whelan, A. J., et al. (2009) · Science · doi:10.1126/science.1174334 · Cited by 682 · see citing works
Trang, P., Wiggins, J. F., Daige, C. L., Cho, C., Omotola, M., Brown, D., Weidhaas, J. B., Bader, A. G., & Slack, F. J. (2011) · Molecular Therapy · doi:10.1038/mt.2011.48 · Cited by 669 · see citing works
A MicroRNA Targeting Dicer for Metastasis Control
Martello, G., Rosato, A., Ferrari, F., Manfrin, A., Cordenonsi, M., Dupont, S., Enzo, E., Guzzardo, V., Rondina, M. B., Spruce, T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.05.017 · Cited by 668 · see citing works
MicroRNA-125b is a novel negative regulator of p53Preprint
Le, M. T. N., Teh, C., Shyh‐Chang, N., Xie, H., Zhou, B., Korzh, V. P., Lodish, H. F., & Lim, B. (2009) · Genes & Development · doi:10.1101/gad.1767609 · Cited by 655 · see citing works
Corney, D. C., Flesken‐Nikitin, A., Godwin, A. K., Wang, W., & Nikitin, A. Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1585 · Cited by 644 · see citing works
The interplay between MYC and HIF in cancer
Dang, C. V., Kim, J., Gao, P., & Yustein, J. T. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2274 · Cited by 614 · see citing works
miR-29 miRNAs activate p53 by targeting p85α and CDC42
Park, S. Y., Lee, J. H., Ha, M., Nam, J., & Kim, V. N. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1533 · Cited by 608 · see citing works
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
Siemens, H., Jackstadt, R., Hünten, S., Kaller, M., Menssen, A., Götz, U., & Hermeking, H. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18552 · Cited by 607 · see citing works
Self-citationReduced expression of Dicer associated with poor prognosis in lung cancer patients
Karube, Y., Tanaka, H., Osada, H., Tomida, S., Tatematsu, Y., Yanagisawa, K., Yatabe, Y., Takamizawa, J., Miyoshi, S., Mitsudomi, T., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00015.x · Cited by 601 · see citing works
Toyota, M., Suzuki, H., Sasaki, Y., Maruyama, R., Imai, K., Shinomura, Y., & Tokino, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0325 · Cited by 600 · see citing works
The expanding universe of p53 targets
Menendez, D., Inga, A., & Resnick, M. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2730 · Cited by 568 · see citing works
Hur, K., Toiyama, Y., Takahashi, M., Balaguer, F., Nagasaka, T., Koike, J., Hemmi, H., Koi, M., Boland, C. R., & Goel, A. (2012) · Gut · doi:10.1136/gutjnl-2011-301846 · Cited by 533 · see citing works
p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
Kim, T., Veronese, A., Pichiorri, F., Lee, T. J., Jeon, Y.-J., Volinia, S., Pineau, P., Marchio, A., Palatini, J., Suh, S.-S., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110235 · Cited by 513 · see citing works
Hermeking, H. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.10.028 · Cited by 494 · see citing works
Self-citationp53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest
Braun, C. J., Zhang, X., Savelyeva, I., Wolff, S., Moll, U. M., Schepeler, T., Orntoft, T. F., Andersen, C. L., & Dobbelstein, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1569 · Cited by 467 · see citing works
Dicer1 functions as a haploinsufficient tumor suppressorPreprint
Kumar, M. S., Pester, R. E., Chen, C. Y., Lane, K. M., Chin, C., Lü, J., Kirsch, D. G., Golub, T. R., & Jacks, T. (2009) · Genes & Development · doi:10.1101/gad.1848209 · Cited by 437 · see citing works
Hermeking, H. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1230 · Cited by 434 · see citing works
Self-citationA p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
Kim, N. H., Kim, H. S., Li, X.-Y., Lee, I., Choi, H.-S., Kang, S. E., Cha, S. Y., Ryu, J. K., Yoon, D., Fearon, E. R., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201103097 · Cited by 434 · see citing works
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
Yamakuchi, M., Lotterman, C., Bao, C., Hruban, R. H., Karim, B. O., Mendell, J. T., Huso, D. L., & Lowenstein, C. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911082107 · Cited by 430 · see citing works
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
Su, X., Chakravarti, D., Cho, M. S., Liu, L.-Z., Gi, Y. J., Lin, Y.-L., Leung, M. L., El‐Naggar, A. K., Creighton, C. J., Suraokar, M. B., et al. (2010) · Nature · doi:10.1038/nature09459 · Cited by 419 · see citing works
Fornari, F., Gramantieri, L., Giovannini, C., Veronese, A., Ferracin, M., Sabbioni, S., Calin, G. A., Grazi, G. L., Croce, C. M., Tavolari, S., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4797 · Cited by 400 · see citing works
Bandi, N., Zbinden, S., Gugger, M., Arnold, M., Kocher, V., Hasan, L., Каппелер, А., Brunner, T., & Vassella, E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4277 · Cited by 386 · see citing works
miR-34 miRNAs provide a barrier for somatic cell reprogramming
Choi, Y. J., Lin, C., Ho, J. J., He, X., Okada, N., Bu, P., Zhong, Y., Kim, S. Y., Bennett, M. J., Chen, C., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2366 · Cited by 381 · see citing works
The ZEB1/miR‐200 feedback loop controls Notch signalling in cancer cells
Brabletz, S., Bajdak-Rusinek, K., Meidhof, S., Burk, U., Niedermann, G., Firat, E., Wellner, U. F., Dimmler, A. W., Faller, G., Schubert, J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.349 · Cited by 369 · see citing works
Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer
Wiklund, E. D., Bramsen, J. B., Hulf, T., Dyrskjøt, L., Ramanathan, R., Hansen, T. B., Villadsen, S. B., Gao, S., Ostenfeld, M. S., Borre, M., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25461 · Cited by 367 · see citing works
miR‐15a and miR‐16‐1 down‐regulation in pituitary adenomas
Bottoni, A., Piccin, D., Tagliati, F., Luchin, A., Zatelli, M. C., & Uberti, E. C. D. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20282 · Cited by 360 · see citing works
Dávalos, V., Moutinho, C., Villanueva, A., Boqué-Sastre, R., Silva, P., Carneiro, F., & Esteller, M. (2011) · Oncogene · doi:10.1038/onc.2011.383 · Cited by 349 · see citing works
Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215
Georges, S. A., Biery, M. C., Kim, S., Schelter, J. M., Guo, J., Chang, A. N., Jackson, A. L., Carleton, M. O., Linsley, P. S., Cleary, M. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1846 · Cited by 348 · see citing works
A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells
Melo, S. A., Moutinho, C., Ropero, S., Calin, G. A., Rossi, S., Spizzo, R., Fernández, A. F., Dávalos, V., Villanueva, A., Montoya, G., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.09.007 · Cited by 347 · see citing works
miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer
Gallardo, E., Navarro, A., Viñolas, N., Marrades, R. M., Díaz, T., Gel, B., Quera, A., Bandrés, E., García‐Foncillas, J., Ramirez, J., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp219 · Cited by 343 · see citing works
DICER1 Mutations in Familial Multinodular Goiter With and Without Ovarian Sertoli-Leydig Cell Tumors
Frio, T. R. (2011) · JAMA · doi:10.1001/jama.2010.1910 · Cited by 341 · see citing works
Dave, N., Guaita‐Esteruelas, S., Gutarra, S., Frías, A., Beltran-Nebot, M., Peiró, S., & de Herreros, A. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.168625 · Cited by 332 · see citing works
Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504
Hu, W., Chan, C. S., Wu, R., Zhang, C., Sun, Y., Song, J. S., Tang, L. H., Levine, A. J., & Feng, Z. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.027 · Cited by 313 · see citing works
Vogt, M., Munding, J. B., Grüner, M., Liffers, S., Verdoodt, B., Hauk, J., Steinstraesser, L., Tannapfel, A., & Hermeking, H. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-010-1030-5 · Cited by 309 · see citing works
Self-citationFrequent Downregulation of miR-34 Family in Human Ovarian Cancers
Corney, D. C., Hwang, C., Matoso, A., Vogt, M., Flesken‐Nikitin, A., Godwin, A. K., Kamat, A. A., Sood, A. K., Ellenson, L. H., Hermeking, H., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2642 · Cited by 309 · see citing works
Self-citationp53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling
Kim, N. H., Kim, N.-G., Kim, N.-G., Lee, I., Choi, H.-S., Li, X.-Y., Kang, S. E., Cha, S. Y., Ryu, J. K., Na, J. M., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001744 · Cited by 308 · see citing works
Ceppi, P., Mudduluru, G., Kumarswamy, R., Rapa, I., Scagliotti, G. V., Papotti, M. G., & Allgayer, H. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0052 · Cited by 304 · see citing works
Repression of the miR‐17‐92 cluster by p53 has an important function in hypoxia‐induced apoptosis
Yan, H., Xue, G., Mei, Q., Wang, Y.-Z., Ding, F., Liu, M., Lü, M., Tang, Y., Yu, H., & Sun, S. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.214 · Cited by 299 · see citing works
Fabbri, M., Bottoni, A., Shimizu, M., Spizzo, R., Nicoloso, M. S., Rossi, S., Barbarotto, E., Cimmino, A., Adair, B., Wojcik, S. E., et al. (2011) · JAMA · doi:10.1001/jama.2010.1919 · Cited by 294 · see citing works
Vrba, L., Jensen, T. J., Garbe, J. C., Heimark, R. L., Cress, A. E., Dickinson, S., Stampfer, M. R., & Futscher, B. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008697 · Cited by 285 · see citing works
Negative regulation of the tumor suppressor p53 gene by microRNAs
Kumar, M., Lu, Z., Takwi, A. A., Chen, W., Callander, N. S., Ramos, K. S., Young, K. H., & Li, Y. (2010) · Oncogene · doi:10.1038/onc.2010.457 · Cited by 284 · see citing works
A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer
Hu, X., MacDonald, D. M., Huettner, P. C., Feng, Z., Naqa, I. E., Schwarz, J. K., Mutch, D. G., Grigsby, P. W., Powell, S. N., & Wang, X. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.05.022 · Cited by 277 · see citing works
Tellez, C. S., Juri, D. E., Do, K., Bernauer, A. M., Thomas, C. L., Damiani, L. A., Tessema, M., Leng, S., & Belinsky, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3035 · Cited by 277 · see citing works
Menssen, A., Hydbring, P., Kapelle, K., Vervoorts, J., Diebold, J., Lüscher, B., Larsson, L., & Hermeking, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105304109 · Cited by 275 · see citing works
Self-citationThe promises and perils of p53
Krizhanovsky, V., & Lowe, S. W. (2009) · Nature · doi:10.1038/4601085a · Cited by 274 · see citing works
Zhang, Y., Yan, L., Wu, Q.-N., Du, Z.-M., Chen, J., Liao, D.-Z., Huang, M., Hou, J.-H., Wu, Q., Zeng, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2435 · Cited by 272 · see citing works
Eades, G. L., Yao, Y., Yang, M., Zhang, Y., Chumsri, S., & Zhou, Q. Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.229401 · Cited by 263 · see citing works
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer
Mudduluru, G., Ceppi, P., Kumarswamy, R., Scagliotti, G. V., Papotti, M., & Allgayer, H. (2011) · Oncogene · doi:10.1038/onc.2011.13 · Cited by 254 · see citing works
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
Ugalde, A. P., Ramsay, A. J., Rosa, J. D. L., Varela, I., Mariño, G., Cadiñanos, J., Lü, J., Freije, J. M. P., & López-Otı́n, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.124 · Cited by 252 · see citing works
Bousquet, M., Quelen, C., Rosati, R., Mas, V. M., Starza, R. L., Bastard, C., Lippert, É., Talmant, P., Lafage‐Pochitaloff, M., Leroux, D., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080285 · Cited by 248 · see citing works
Epigenetic Inactivation of the miR-124-1 in Haematological Malignancies
Wong, K. Y., So, C. C., Loong, F., Chung, L.-P., Lam, W. W. L., Liang, R. H. S., Li, G. K. H., Jin, D., & Chim, C. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019027 · Cited by 247 · see citing works
Lal, A., Thomas, M. P., Altschuler, G. M., Navarro, F., O’Day, E. M., Li, X. L., Concepcion, C. P., Han, Y.-C., Thiery, J., Rajani, D. K., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002363 · Cited by 245 · see citing works
miR-449 inhibits cell proliferation and is down-regulated in gastric cancer
Kheir, T. B., Futoma-Kazmierczak, E., Skanderup, A. J., Krogh, A., Bardram, L., Hother, C., Grønbæk, K., Federspiel, B., Lund, A. H., & Friis-Hansen, L. J. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-29 · Cited by 241 · see citing works
MiR-15a and MiR-16 Control Bmi-1 Expression in Ovarian Cancer
Bhattacharya, R., Nicoloso, M. S., Arvizo, R. R., Wang, E., Cortez, A., Rossi, S., Calin, G. A., & Mukherjee, P. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2552 · Cited by 240 · see citing works
Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer
Musumeci, M., Coppola, V., Addario, A., Patrizii, M., Maugeri‐Saccà, M., Memeo, L., Colarossi, C., Francescangeli, F., Biffoni, M., Collura, D., et al. (2011) · Oncogene · doi:10.1038/onc.2011.140 · Cited by 236 · see citing works
Tivnan, A., Orr, W. S., Gubala, V., Nooney, R. I., Williams, D. E., McDonagh, C. M., Prenter, S., Harvey, H. M., Domingo-Fernandéz, R., Bray, I. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038129 · Cited by 233 · see citing works
Spizzo, R., Nicoloso, M. S., Croce, C. M., & Calin, G. A. (2009) · Cell · doi:10.1016/j.cell.2009.04.040 · Cited by 232 · see citing works
p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells
Jain, A. K., Allton, K. L., Iacovino, M., Mahen, E. M., Milczarek, R. J., Zwaka, T. P., Kyba, M., & Barton, M. C. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001268 · Cited by 226 · see citing works
Lee, K.-H., Lotterman, C., Karikari, C. A., Omura, N., Feldmann, G., Habbe, N., Goggins, M., Mendell, J. T., & Maitra, A. (2009) · Pancreatology · doi:10.1159/000186051 · Cited by 225 · see citing works
MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer
Suh, S. O., Chen, Y., Zaman, M. S., Hirata, H., Yamamura, S., Shahryari, V., Liu, J., Tabatabai, Z. L., Kakar, S., Deng, G., et al. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr036 · Cited by 206 · see citing works
Kaller, M., Liffers, S., Oeljeklaus, S., Kuhlmann, K., Röh, S., Hoffmann, R. F. G., Warscheid, B., & Hermeking, H. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010462 · Cited by 203 · see citing works
Self-citationSwarbrick, A., Woods, S. L., Shaw, A., Balakrishnan, A., Phua, Y. W., Nguyen, A., Chanthery, Y. H., Lim, L., Ashton, L. J., Judson, R. L., et al. (2010) · Nature Medicine · doi:10.1038/nm.2227 · Cited by 199 · see citing works
Leucci, E., Cocco, M., Onnis, A., Falco, G. D., van Cleef, P., Bellan, C., van Rijk, A. F., Nyagol, J. A., Byakika, B., Lazzi, S., et al. (2008) · The Journal of Pathology · doi:10.1002/path.2410 · Cited by 198 · see citing works
Suzuki, H., Yamamoto, E., Nojima, M., Kai, M., Yamano, H., Yoshikawa, K., Kimura, T., Kudo, T., Harada, E., Sugai, T., et al. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq203 · Cited by 196 · see citing works
Dysregulation of miR-15a and miR-214 in human pancreatic cancer
Zhang, X., Ye, H., Zeng, C., He, B., Zhang, H., & Chen, Y. Q. (2010) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-3-46 · Cited by 196 · see citing works
CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation
Burns, D. M., D’Ambrogio, A., Nottrott, S., & Richter, J. D. (2011) · Nature · doi:10.1038/nature09908 · Cited by 193 · see citing works
microRNAs: A Safeguard against Turmoil?
Leung, A. K. L., & Sharp, P. A. (2007) · Cell · doi:10.1016/j.cell.2007.08.010 · Cited by 192 · see citing works
miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress
Xiao, J., Lin, H., Luo, X., Luo, X., & Wang, Z. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.347 · Cited by 189 · see citing works
Down-regulation of miR-141 in gastric cancer and its involvement in cell growth
Du, Y., Xu, Y., Ding, L., Yao, H., Yu, H., Zhou, T., & Si, J. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0037-7 · Cited by 183 · see citing works
MicroRNAs Differentially Expressed in ACTH-Secreting Pituitary Tumors
Amaral, F. C., Torres, N., Saggioro, F. P., Neder, L., Machado, H. R., Silva, W. A., Moreira, A. C., & de Castro, M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1451 · Cited by 182 · see citing works
Earle, J. S. L., Luthra, R., Romans, A., Abraham, R., Ensor, J., Yao, H., & Hamilton, S. R. (2010) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2010.090154 · Cited by 181 · see citing works
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
Mudhasani, R., Zhu, Z., Hutvágner, G., Eischen, C. M., Lyle, S. R., Hall, L. L., Lawrence, J. B., Imbalzano, A. N., & Jones, S. N. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200802105 · Cited by 179 · see citing works
Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells
Neves, R. P., Scheel, C., Weinhold, S., Honisch, E., Iwaniuk, K. M., Trompeter, H., Niederacher, D., Wernet, P., Santourlidis, S., & Uhrberg, M. (2010) · BMC Research Notes · doi:10.1186/1756-0500-3-219 · Cited by 177 · see citing works
Diederichs, S., & Haber, D. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0537 · Cited by 176 · see citing works
miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1
Roybal, J. D., Zang, Y., Ahn, Y., Yang, Y., Gibbons, D. L., Baird, B. N., Alvarez, C., Thilaganathan, N., Liu, D. D., Saintigny, P., et al. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0497 · Cited by 174 · see citing works
In-depth characterization of the microRNA transcriptome in a leukemia progression modelPreprint
Kuchenbauer, F. C., Morin, R. D., Argiropoulos, B., Petriv, O. I., Griffith, M., Heuser, M., Yung, E., Piper, J., Delaney, A. D., Prabhu, A., et al. (2008) · Genome Research · doi:10.1101/gr.077578.108 · Cited by 173 · see citing works
mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1
Schickel, R., Park, S.-M., Murmann, A. E., & Peter, M. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.018 · Cited by 167 · see citing works
Pallasch, C., Patz, M., Park, Y., Hagist, S., Eggle, D., Claus, R., Debey-Pascher, S., Schulz, A., Frenzel, L., Claasen, J., et al. (2009) · Blood · doi:10.1182/blood-2009-06-229898 · Cited by 165 · see citing works
A pipeline for the generation of shRNA transgenic mice
Dow, L. E., Premsrirut, P. K., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, R. A., Hannon, G. J., & Lowe, S. W. (2012) · Nature Protocols · doi:10.1038/nprot.2011.446 · Cited by 159 · see citing works
Ragimov, N., Krauskopf, A., Navot, N., Rotter, V., Oren, M., & Aloni, Y. (1993) · PubMed · Cited by 159 · see citing works
Le, M. T. N., Shyh-Chang, N., Khaw, S. L., Chin, L., Teh, C., Tay, J., O'Day, E., Korzh, V., Yang, H., Lal, A., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002242 · Cited by 158 · see citing works
Vallejo, D. M., Caparrós, E., & Domínguez, M. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.358 · Cited by 157 · see citing works
Epigenetic inactivation of the miR-34a in hematological malignancies
Chim, C. S., Wong, K. Y., Qi, Y., Loong, F., Lam, W. L., Wong, L., Jin, D., Costello, J., & Liang, R. H. S. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq033 · Cited by 157 · see citing works
Bandi, N., & Vassella, E. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-55 · Cited by 154 · see citing works
FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
Gan, B., Lim, C., Chu, G., Hua, S., Ding, Z., Collins, M. P., HU, J. L., Jiang, S., Fletcher-Sananikone, E., Zhuang, L., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.019 · Cited by 145 · see citing works
Bui, T. V., & Mendell, J. T. (2010) · Genes & Cancer · doi:10.1177/1947601910377491 · Cited by 137 · see citing works
MicroRNA-449 in cell fate determination
Lizé, M., Klimke, A., & Dobbelstein, M. (2011) · Cell Cycle · doi:10.4161/cc.10.17.17181 · Cited by 136 · see citing works
MicroRNA miR-125b is a prognostic marker in human colorectal cancer
Mori (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.969 · Cited by 135 · see citing works
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
Hwang, C., Matoso, A., Corney, D. C., Flesken‐Nikitin, A., Körner, S., Wang, W., Boccaccio, C., Thorgeirsson, S. S., Comoglio, P. M., Hermeking, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017536108 · Cited by 133 · see citing works
Self-citationKubo, T., Toyooka, S., Tsukuda, K., Sakaguchi, M., Fukazawa, T., Soh, J., Asano, H., Ueno, T., Muraoka, T., Yamamoto, H., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3040 · Cited by 125 · see citing works
DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancer
Wang, Z., Chen, Z., Gao, Y., Li, N., Li, B., Tan, F., Tan, X., Lü, N., Sun, Y., Sun, J., et al. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.5.14550 · Cited by 125 · see citing works
Zhu, H., Dougherty, U., Robinson, V. L., Mustafi, R., Pekow, J. R., Kupfer, S. S., Li, Y.-C., Hart, J. A. L., Goss, K. H., Fichera, A., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0531 · Cited by 119 · see citing works
miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration
Staton, A. A., Knaut, H., & Giráldez, A. J. (2011) · Nature Genetics · doi:10.1038/ng.758 · Cited by 116 · see citing works
CpG island methylation status of miRNAs in esophageal squamous cell carcinoma
Chen, X., Hu, H., Guan, X., Xiong, G., Wang, Y., Wang, K., Li, J., Xu, X., Yang, K., & Bai, Y. (2011) · International Journal of Cancer · doi:10.1002/ijc.26171 · Cited by 115 · see citing works
Kim, M. S., Oh, J. E., Kim, Y. R., Park, S. W., Kang, M. R., Kim, S. S., An, C. H., Yoo, N. J., & Lee, S. H. (2010) · The Journal of Pathology · doi:10.1002/path.2683 · Cited by 114 · see citing works
Li, X., Zhang, Y., Shi, Y., Dong, G., Liang, J., Han, Y., Wang, X., Zhao, Q., Ding, J., Wu, K., et al. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01194.x · Cited by 110 · see citing works
miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal
Herrera-Merchan, A., Cerrato, C., Luengo, G., Domı́nguez, O., Piris, M. A., Serrano, M., & González, S. (2010) · Cell Cycle · doi:10.4161/cc.9.16.12598 · Cited by 110 · see citing works
Li, W., Chen, C., Xu, M., Guo, J., Li, Y., Xia, Q., Liu, H., He, J., Yu, H., & Zhu, L. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08075.x · Cited by 107 · see citing works
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity
Léveillé, N., Elkon, R., Dávalos, V., Manoharan, V., Hollingworth, D., Vrielink, J. A. F. O., le Sage, C., Melo, C. A., Horlings, H. M., Wesseling, J., et al. (2011) · Nature Communications · doi:10.1038/ncomms1519 · Cited by 98 · see citing works
A resource of vectors and ES cells for targeted deletion of microRNAs in mice
Prosser, H. M., Koike-Yusa, H., Cooper, J. D., Law, F., & Bradley, A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1929 · Cited by 93 · see citing works
Prognostic Significance of miR-215 in Colon Cancer
Karaayvaz, M., Pal, T., Song, B., Zhang, C., Georgakopoulos, P., Mehmood, S., Burke, S., Shroyer, K., & Ju, J. (2011) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2011.06.002 · Cited by 91 · see citing works
Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer
Kalimutho, M., Cecilia, S. D., Blanco, G. D. V., Roviello, F., Sileri, P., Cretella, M., Formosa, A., Corso, G., Marrelli, D., Pallone, F., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.82 · Cited by 90 · see citing works
Systematic Proteome Analysis Identifies Transcription Factor YY1 as a Direct Target of miR-34a
Chen, Q., Yu, L., Tsang, P., Wei, J. S., Song, Y., Cheuk, A., Chung, J., Hewitt, S. M., Veenstra, T. D., & Khan, J. I. (2010) · Journal of Proteome Research · doi:10.1021/pr1006697 · Cited by 87 · see citing works
Panda, H., Pelakh, L., Chuang, T., Luo, X., Bükülmez, O., & Chegini, N. (2012) · Reproductive Sciences · doi:10.1177/1933719112438448 · Cited by 86 · see citing works
Böhlig, L., Friedrich, M., & Engeland, K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq796 · Cited by 85 · see citing works
MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3′ untranslated region
Tian, S., Huang, S., Wu, S., Guo, W., Li, J., & He, X. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.112 · Cited by 85 · see citing works
Eμ/miR-125b transgenic mice develop lethal B-cell malignancies
Enomoto, Y., Kitaura, J., Hatakeyama, K., Watanuki, J., Akasaka, T., Kato, N., Shimanuki, M., Nishimura, K., Takahashi, M., Taniwaki, M., et al. (2011) · Leukemia · doi:10.1038/leu.2011.166 · Cited by 81 · see citing works
Kahlert, C., Klupp, F., Brand, K., Lasitschka, F., Diederichs, S., Kirchberg, J., Rahbari, N. N., Dutta, S., Bork, U., Fritzmann, J., et al. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02023.x · Cited by 81 · see citing works
A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes
Careccia, S., Mainardi, S., Pelosi, A., Gurtner, A., Diverio, D., Riccioni, R., Testa, U., Pelosi, E., Piaggio, G., Sacchi, A., et al. (2009) · Oncogene · doi:10.1038/onc.2009.255 · Cited by 81 · see citing works
TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade
Soussi, T. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-386469-7.00005-0 · Cited by 73 · see citing works
p53 connects tumorigenesis and reprogramming to pluripotency
Tàpia, N., & Schöler, H. R. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101866 · Cited by 71 · see citing works
Li, N., Kaur, S., Greshock, J., Lassus, H., Zhong, X.-M., Wang, Y., Leminen, A., Shao, Z.-M., Hu, X., Liang, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2484 · Cited by 67 · see citing works
Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER1
Ravi, A., Gurtan, A. M., Kumar, M. S., Bhutkar, A. J., Chin, C., Lu, V., Lees, J. A., Jacks, T., & Sharp, P. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.037 · Cited by 66 · see citing works
Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met
Cai (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000378 · Cited by 63 · see citing works
MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets.
Dong, F., & Lou, D. (2012) · PubMed Central · Cited by 62 · see citing works
Leaderer, D., Hoffman, A. E., Zheng, T., Fu, A., Weidhaas, J. B., Paranjape, T., & Zhu, Y. (2011) · Europe PMC (PubMed Central) · Cited by 60 · see citing works
To repress or not to repress: This is the guardian's question
Rinn, J. L., & Huarte, M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.002 · Cited by 56 · see citing works
Rücker, F. G., Russ, A. C., Cocciardi, S., Kett, H., Schlenk, R. F., Botzenhardt, U., Langer, C., Krauter, J., Fröhling, S., Schlegelberger, B., et al. (2012) · Leukemia · doi:10.1038/leu.2012.208 · Cited by 49 · see citing works
The miR‐15a‐miR‐16‐1 locus is homozygously deleted in a subset of prostate cancers
Porkka, K. P., Ogg, E.-L., Saramäki, O. R., Vessella, R. L., Pukkila, H., Lähdesmäki, H. J., van Weerden, W. M., Wolf, M., Kallioniemi, O., Jenster, G. W., et al. (2011) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20873 · Cited by 47 · see citing works
BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties
Nishida (2010) · International Journal of Oncology · doi:10.3892/ijo.2010.864 · Cited by 45 · see citing works
Brabletz, T. (2012) · Cell Cycle · doi:10.4161/cc.11.2.18900 · Cited by 44 · see citing works
Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
Kamimae, S., Yamamoto, E., Yamano, H., Nojima, M., Suzuki, H., Ashida, M., Hatahira, T., Satô, A., Kimura, T., Yoshikawa, K., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0214 · Cited by 41 · see citing works
Chang, C.-J., Chao, C.-H., Xia, W., Yang, J.-Y., Xiong, Y., Li, C.-W., Yu, W.-H., Rehman, S. K., Hsu, J. L., Lee, H., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2401 · Cited by 15 · see citing works
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Jansson, M., & Lund, A. H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.006 · Cited by 1,120 · see citing works
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080 · see citing works
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
MicroRNA-34a regulates cardiac ageing and function.
Boon, R. A., Iekushi, K., Lechner, S., Seeger, T., Fischer, A., Heydt, S., Kaluza, D., Tréguer, K., Carmona, G., Bonauer, A., et al. (2013) · Nature · doi:10.1038/nature11919 · Cited by 821 · see citing works
Self-citationTumor suppressor p53: Biology, signaling pathways, and therapeutic targeting
Borrero, L. J. H., & El‐Deiry, W. S. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188556 · Cited by 773 · see citing works
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Rokavec, M., Öner, M. G., Li, H., Jackstadt, R., Jiang, L., Lodygin, D., Kaller, M., Horst, D., Ziegler, P. K., Schwitalla, S., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73531 · Cited by 753 · see citing works
Self-citationIntegrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
Donehower, L. A., Soussi, T., Korkut, A., Liu, Y., Schultz, A., Cardenas, M., Li, X., Babur, Ö., Hsu, T., Lichtarge, O., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.001 · Cited by 707 · see citing works
Reddy, K. B. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0185-1 · Cited by 620 · see citing works
Inflammatory Response in the CNS: Friend or Foe?
Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works
MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer
Zhang, L., Liao, Y., & Tang, L. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1059-5 · Cited by 514 · see citing works
Non-coding RNA regulatory networks
Panni, S., Lovering, R. C., Porras, P., & Orchard, S. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194417 · Cited by 479 · see citing works
MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance
Iqbal, M. A., Arora, S., Prakasam, G., Călin, G. A., & Syed, M. A. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.07.003 · Cited by 449 · see citing works
The Role of miRNAs in Regulating Gene Expression Networks
Gurtan, A. M., & Sharp, P. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.007 · Cited by 441 · see citing works
TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade
Leroy, B., Anderson, M., & Soussi, T. (2014) · Human Mutation · doi:10.1002/humu.22552 · Cited by 412 · see citing works
Fischer, M., Grossmann, P., Padi, M., & DeCaprio, J. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw523 · Cited by 330 · see citing works
Contribution of p53 to Metastasis
Powell, E., Piwnica-Worms, D. R., & Piwnica-Worms, H. M. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0136 · Cited by 353 · see citing works
The p53/miR-34 axis in development and disease
Rokavec, M., Li, H., Jiang, L., & Hermeking, H. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju003 · Cited by 354 · see citing works
Self-citationNon-coding RNAs and potential therapeutic targeting in cancer
Toden, S., Zumwalt, T. J., & Goel, A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188491 · Cited by 327 · see citing works
Xiao, C., Wang, K., Xu, Y., Hu, H., Zhang, N., Wang, Y., Zhong, Z., Zhao, J., Li, Q., Zhu, D., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.312758 · Cited by 287 · see citing works
Tian, X., Zhang, H., & Xing, J. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.07.011 · Cited by 276 · see citing works
Hypoxia: A master regulator of microRNA biogenesis and activity
Nallamshetty, S., Chan, S. Y., & Loscalzo, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.022 · Cited by 281 · see citing works
The complexity of p53-mediated metabolic regulation in tumor suppression
Liu, Y., & Gu, W. J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.010 · Cited by 260 · see citing works
Noncoding <scp>RNA</scp>s in disease
Lekka, E., & Hall, J. (2018) · FEBS Letters · doi:10.1002/1873-3468.13182 · Cited by 251 · see citing works
Toden, S., Okugawa, Y., Jascur, T. A., Wodarz, D., Komarova, N. L., Buhrmann, C., Shakibaei, M., Boland, C. R., & Goel, A. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv006 · Cited by 249 · see citing works
Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe‐Seyler, K., & Hoppe‐Seyler, F. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004712 · Cited by 250 · see citing works
Small RNA combination therapy for lung cancer
Xue, W., Dahlman, J. E., Tammela, T., Khan, O. F., Sood, S., Dave, A., Cai, W., Chirino, L. M., Yang, G. R., Bronson, R. T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412686111 · Cited by 243 · see citing works
miRNA biogenesis: Biological impact in the development of cancer
Romero-Cordoba, S. L., Salido-Guadarrama, I., Rodríguez‐Dorantes, M., & Hidalgo‐Miranda, A. (2014) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.955442 · Cited by 226 · see citing works
Yang, J., Zhang, Z., Chen, C., Liu, Y., Si, Q., Chuang, T.-H., Li, N., Gomez‐Cabrero, A., Reisfeld, R., Xiang, R., et al. (2013) · Oncogene · doi:10.1038/onc.2013.258 · Cited by 213 · see citing works
miR-34 and p53: New Insights into a Complex Functional Relationship
Navarro, F., & Lieberman, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132767 · Cited by 203 · see citing works
MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside
To, K. K. W., Tong, C. W. S., Wu, M., & Cho, W. C. S. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i27.2949 · Cited by 195 · see citing works
Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis
Liu, C., Rokavec, M., Huang, Z., & Hermeking, H. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01178-1 · Cited by 199 · see citing works
Self-citationmiR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1
Shang, Y., Zhang, Z., Liu, Z., Feng, B., Ren, G., Li, K.-J., Zhou, L., Sun, Y., Li, M., Zhou, J., et al. (2013) · Oncogene · doi:10.1038/onc.2013.297 · Cited by 189 · see citing works
Toden, S., Tran, H.-M. T., Tovar-Camargo, O. A., Okugawa, Y., & Goel, A. (2016) · Oncotarget · doi:10.18632/oncotarget.7567 · Cited by 187 · see citing works
MicroRNAs in the ionizing radiation response and in radiotherapy
Metheetrairut, C., & Slack, F. J. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.01.002 · Cited by 185 · see citing works
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works
MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis
Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H. G., Mohammadi, A., Gjerstorff, M. F., & Baradaran, B. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.017 · Cited by 169 · see citing works
SNAIL and miR‐34a feed‐forward regulation of ZNF281/ZBP99 promotes epithelial–mesenchymal transition
Hahn, S., Jackstadt, R., Siemens, H., Hünten, S., & Hermeking, H. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.236 · Cited by 164 · see citing works
Self-citationA step-by-step microRNA guide to cancer development and metastasis
Markopoulos, G. S., Roupakia, E., Tokamani, M., Chavdoula, E., Hatziapostolou, M., Polytarchou, C., Marcu, K. B., Papavassiliou, A. G., Sandaltzopoulos, R., & Kolettas, E. (2017) · Cellular Oncology · doi:10.1007/s13402-017-0341-9 · Cited by 161 · see citing works
Eischen, C. M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026096 · Cited by 161 · see citing works
Deshpande, S., Putta, S., Wang, M., Lai, J. Y., Bitzer, M., Nelson, R. G., Lanting, L. L., Kato, M. V., & Natarajan, R. D. (2013) · Diabetes · doi:10.2337/db13-0305 · Cited by 161 · see citing works
Li, X. L., Subramanian, M., Jones, M. F., Chaudhary, R., Singh, D. K., Zong, X., Gryder, B. E., Sindri, S., Mo, M., Schetter, A. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.041 · Cited by 160 · see citing works
Li, H., Rokavec, M., Jiang, L., Horst, D. A., & Hermeking, H. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.04.017 · Cited by 157 · see citing works
Self-citationMicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential
Wang, W. T., & Luo, Y. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400184 · Cited by 153 · see citing works
Role of the lncRNA-p53 regulatory network in cancer
Zhang, A., Xu, M., & Mo, Y. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju013 · Cited by 144 · see citing works
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Zeng, Z., Fu, M., Hu, Y., Wei, Y., Wei, X., & Luo, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01877-w · Cited by 143 · see citing works
Siemens, H., Neumann, J. H. L., Jackstadt, R., Mansmann, U., Horst, D. A., Kirchner, T., & Hermeking, H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1703 · Cited by 141 · see citing works
Self-citationMarques, T. M., Kuiperij, H. B., Bruinsma, I. B., van Rumund, A., Aerts, M. B., Esselink, R. A. J., Bloem, B. R., & Verbeek, M. M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0253-0 · Cited by 141 · see citing works
Liu, J., Zhang, C., Zhao, Y., & Feng, Z. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25609 · Cited by 139 · see citing works
LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years
Tam, C., Wong, J. H., Tsui, S. K., Zuo, T., Chan, T., & Ng, T. B. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09837-5 · Cited by 139 · see citing works
Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga‐Tomita, T., Yasuda, S., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aat5185 · Cited by 135 · see citing works
Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies
Kumar, S., Gonzalez, E. A., Rameshwar, P., & Etchegaray, J. (2020) · Cancers · doi:10.3390/cancers12123657 · Cited by 136 · see citing works
Ren, D., WANG, M., Guo, W., Zhao, X., Tu, X.-A., Huang, S., Zou, X., & Peng, X. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1825 · Cited by 135 · see citing works
Siemens, H., Jackstadt, R., Kaller, M., & Hermeking, H. (2013) · Oncotarget · doi:10.18632/oncotarget.1202 · Cited by 135 · see citing works
Self-citationCharity begins at home: non-coding RNA functions in DNA repair
Chowdhury, D., Choi, Y. E., & Brault, M. E. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3523 · Cited by 132 · see citing works
Toden, S., Okugawa, Y., Buhrmann, C., Nattamai, D., Anguiano, E., Baldwin, N. E., Shakibaei, M., Boland, C. R., & Goel, A. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0354 · Cited by 131 · see citing works
Tumor suppressor p53 and its gain-of-function mutants in cancer
Liu, J., Zhang, C., & Feng, Z. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt144 · Cited by 128 · see citing works
Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism
Yang, X. P., Wang, Z., Zandkarimi, F., Liu, Y., Duan, S., Li, Z., Kon, N., Zhang, Z., Jiang, X., Stockwell, B. R., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.014 · Cited by 131 · see citing works
Shi, L., Jackstadt, R., Siemens, H., Li, H., Kirchner, T., & Hermeking, H. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-2203 · Cited by 125 · see citing works
Self-citationGu, C.-C., Cai, J., Xu, Z., Zhou, S., Ye, L., Yan, Q., Zhang, Y., Fang, Y., Liu, Y., Tu, C., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1962-x · Cited by 124 · see citing works
Wang, S.-H., Ma, F., Tang, Z., Wu, X., Cai, Q., Zhang, M., Weng, M., Zhou, D., Wang, J., & Quan, Z.-W. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0436-6 · Cited by 117 · see citing works
MicroRNAs as regulators and mediators of c-MYC function
Jackstadt, R., & Hermeking, H. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.04.003 · Cited by 113 · see citing works
Self-citationp53 regulates glucose metabolism by miR-34a
Kim, H.-R., Roe, J., Lee, J., Cho, E., & Youn, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.043 · Cited by 109 · see citing works
The emerging roles of microRNAs in cancer metabolism
Chan, B., Manley, J., Lee, J., & Singh, S. R. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.10.011 · Cited by 109 · see citing works
Cheng, C.-Y., Hwang, C., Corney, D. C., Flesken‐Nikitin, A., Jiang, L., Öner, M. G., Munroe, R. J., Schimenti, J. C., Hermeking, H., & Nikitin, A. Y. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.023 · Cited by 108 · see citing works
Self-citationEpigenetic mechanisms and the hallmarks of cancer: an intimate affair.
Darwiche, N. (2020) · PubMed Central · Cited by 105 · see citing works
The CDX1–microRNA-215 axis regulates colorectal cancer stem cell differentiation
Jones, M. F., Hara, T., Francis, P., Li, X. L., Bilke, S., Zhu, Y. J., Pineda, M. A., Subramanian, M., Bodmer, W. F., & Lal, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503370112 · Cited by 106 · see citing works
Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players
Deng, G., & Sui, G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918319 · Cited by 105 · see citing works
The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses
Cui, D., Qu, R., Liu, D., Xiong, X., Liang, T., & Zhao, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.775507 · Cited by 106 · see citing works
Ruggeri, C., Gioffré, S., Achilli, F., Colombo, G. I., & D’Alessandra, Y. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9653-0 · Cited by 105 · see citing works
Intercellular Communication between Airway Epithelial Cells Is Mediated by Exosome-Like Vesicles
Gupta, R., Radicioni, G., Abdelwahab, S. H., Dang, H., Carpenter, J., Chua, M., Mieczkowski, P. A., Sheridan, J. T., Randell, S. H., & Kesımer, M. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0156oc · Cited by 104 · see citing works
When Oxidative Stress Meets Epigenetics: Implications in Cancer Development
García-Guede, Á., Vera, O., & de Cáceres, I. I. (2020) · Antioxidants · doi:10.3390/antiox9060468 · Cited by 107 · see citing works
Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer
Shi, X., Kaller, M., Rokavec, M., Kirchner, T., Horst, D. A., & Hermeking, H. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.002 · Cited by 101 · see citing works
Self-citationDong, R., Liu, X., Zhang, Q., Jiang, Z., Li, Y., Wei, Y., Li, Y., Yang, Q., Liu, J., Wei, J., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2522 · Cited by 99 · see citing works
miR-34a and miR-34b/c Suppress Intestinal Tumorigenesis
Jiang, L., & Hermeking, H. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2183 · Cited by 99 · see citing works
Self-citationGu, L., Deng, Z. J., Roy, S., & Hammond, P. T. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2186 · Cited by 98 · see citing works
p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms
Pitolli, C., Wang, Y., Candi, E., Shi, Y., Melino, G., & Amelio, I. (2019) · Cancers · doi:10.3390/cancers11121983 · Cited by 98 · see citing works
New insights into the expression profile and function of micro-ribonucleic acid in human spermatozoa
Salas‐Huetos, A., Blanco, J., Vidal, F., Mercader, J. M., Garrido, N., & Antón, E. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.03.040 · Cited by 96 · see citing works
miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression
Mu, W., Hu, C., Zhang, H., Qu, Z., Cen, J., Qiu, Z., Li, C., Ren, H., Li, Y., He, X., et al. (2015) · Cell Research · doi:10.1038/cr.2015.23 · Cited by 95 · see citing works
Antitumor effect of miR-197 targeting in p53 wild-type lung cancer
Fiori, M. E., Barbini, C., Haas, T. L., Marroncelli, N., Patrizii, M., Biffoni, M., & Maria, R. D. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.6 · Cited by 94 · see citing works
Revealing a human p53 universe
Nguyen, T., Grimm, S. A., Bushel, P. R., Li, J., Li, Y., Bennett, B. D., Lavender, C. A., Ward, J. M., Fargo, D. C., Anderson, C. W., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky720 · Cited by 94 · see citing works
Wang, N., Zhu, M., Wang, X., Tan, H., Tsao, S., & Feng, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.027 · Cited by 93 · see citing works
Otsuka, K., Yamamoto, Y., & Ochiya, T. (2018) · Oncotarget · doi:10.18632/oncotarget.25339 · Cited by 93 · see citing works
miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment
Conti, I., Varano, G., Simioni, C., Laface, I., Milani, D., Rimondi, E., & Neri, L. M. (2020) · Cells · doi:10.3390/cells9010220 · Cited by 91 · see citing works
Belonging to a network—microRNAs, extracellular vesicles, and the glioblastoma microenvironment
Godlewski, J. A., Krichevsky, A. M., Johnson, M. D., Chiocca, E. A., & Bronisz, A. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou292 · Cited by 91 · see citing works
Regulation of miR-34 Family in Neuronal Development
Jauhari, A., Singh, T., Singh, P., Parmar, D., & Yadav, S. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0359-4 · Cited by 90 · see citing works
Aberrant regulation of FBW7 in cancer
Wang, L., Ye, X., Liu, Y., Wei, W., & Wang, Z. P. (2014) · Oncotarget · doi:10.18632/oncotarget.1859 · Cited by 89 · see citing works
Long noncoding RNAs in the p53 network
Chaudhary, R., & Lal, A. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1410 · Cited by 88 · see citing works
Schlereth, K., Heyl, C., Krampitz, A.-M., Mernberger, M., Finkernagel, F., Scharfe, M., Jarek, M., Leich, E., Rosenwald, A., & Stiewe, T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003726 · Cited by 87 · see citing works
p53, a translational regulator: contribution to its tumour-suppressor activity
Marcel, V., Catez, F., & Diaz, J. (2015) · Oncogene · doi:10.1038/onc.2015.25 · Cited by 88 · see citing works
Lezina, L., Purmessur, N. S., Antonov, A. V., Ivanova, T., Karpova, E., Kumar, K., Ivan, M., Aksenova, V., Tentler, D., Garabadgiu, A. V., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.483 · Cited by 86 · see citing works
miR-661 downregulates both Mdm2 and Mdm4 to activate p53
Hoffman, Y., Bublik, D. R., Pilpel, Y., & Oren, M. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.146 · Cited by 86 · see citing works
Chaudhary, R., Gryder, B. E., Woods, W. S., Subramanian, M., Jones, M. F., Li, X. L., Jenkins, L. M. M., Shabalina, S. A., Mo, M., Dasso, M., et al. (2017) · eLife · doi:10.7554/elife.23244 · Cited by 84 · see citing works
Zhou, J., Chen, X., Zhao, J., Bao, Z., Chen, X., Zhang, P., Liu, Z.-F., & Zhou, J. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.06.010 · Cited by 85 · see citing works
Yang, Y., Yuan, H., Zhao, L., Guo, S., Hu, S., Tian, M., Nie, Y., Yu, J., Zhou, C., Niu, J., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01007-x · Cited by 86 · see citing works
The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer
Shang, Y., Feng, B., Zhou, L., Ren, G., Zhang, Z., Fan, X., Sun, Y., Luo, G., Liang, J., Wu, K., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6374 · Cited by 84 · see citing works
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
Thapar, R. (2018) · Molecules · doi:10.3390/molecules23112789 · Cited by 83 · see citing works
Allouch, S., Malki, A. M., Allouch, A., Gupta, I., Vranić, S., & Moustafa, A. A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00914 · Cited by 84 · see citing works
Regulation of mi RNA biogenesis and turnover in the immune system
Bronevetsky, Y., & Ansel, K. M. (2013) · Immunological Reviews · doi:10.1111/imr.12059 · Cited by 84 · see citing works
Non‐coding RNAs in DNA damage and repair
Sharma, V., & Misteli, T. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.05.006 · Cited by 83 · see citing works
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells
Zhao, S., Liu, H., Liu, Y., Wu, J., Wang, C., Hou, X., Chen, X., Yang, G., Zhao, L., Che, H., et al. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.01.039 · Cited by 83 · see citing works
- Authors
- Hermeking, H.
- Affiliations
- Pathologisches Institut (DE)
- Corresponding author
- Hermeking, Heiko
- ORCID
- Hermeking, Heiko
- Venue
- Nature Reviews Cancer
- Published
- 2012-08-17
- Volume
- 12
- Issue
- 9
- Pages
- 613-626
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1970431885
- Cited by
- 518
- References
- 185
- Citations by year
- 2026: 13 · 2025: 8 · 2024: 29 · 2023: 23 · 2022: 34 · 2021: 29 · 2020: 32 · 2019: 31 · 2018: 31 · 2017: 44 · 2016: 54 · 2015: 59 · 2014: 76 · 2013: 47 · 2012: 8
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, p53, tumor suppression, p53 pathway, cell cycle regulation, epithelial-mesenchymal transition, cancer stemness, cancer metabolism, angiogenesis, cell survival, epigenetic modifications, cancer diagnosis, cancer therapeutics
- MeSH terms
- Humans, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, MicroRNAs
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