Cited by 526MicroRNA in disease regulationCancer-related Molecular PathwaysCancer-related molecular mechanisms research

MicroRNAs in the p53 network: micromanagement of tumour suppression

Hermeking, Heiko·2012·Nature Reviews Cancer

Abstract

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated miRNAs contribute to tumour suppression by controlling the expression of central components of multiple processes, including cell cycle progression, epithelial-mesenchymal transition, stemness, metabolism, cell survival and angiogenesis. The expression and activity of p53 itself is also under the control of miRNAs. Finally, genetic and epigenetic alterations identified in the p53-miRNA network indicate that these pathways are important for the initiation and progression of tumours. In the future, knowledge about the p53-miRNA network may be able to be exploited for diagnostic and therapeutic approaches in cancer prevention and treatment.

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Crossref · 10.1038/nrc3318

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185 of 185 references verified0 citation errors · 0 not checkable

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  • Several noncoding RNAs, including microRNAs and long noncoding RNAs such as TUG1, miR-34, lincRNA-p21, PANDA and PINT, were reported to mediate p53-dependent gene regulation.

    “Several noncoding RNAs were reported to mediate p53-dependent gene regulation—these include microRNAs120 and long noncoding RNAs,121 such as TUG1,122, 123 miR-34,124 lincRNA-p21,125 PANDA126 and PINT.127”

    From Census and evaluation of p53 target genes (2017) · cites this paper as [120]

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Authors
Hermeking, H.
Affiliations
Pathologisches Institut (DE)
Corresponding author
Hermeking, Heiko
Venue
Nature Reviews Cancer
Published
2012-08-17
Volume
12
Issue
9
Pages
613-626
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W1970431885
Cited by
518
References
185
Citations by year
2026: 13 · 2025: 8 · 2024: 29 · 2023: 23 · 2022: 34 · 2021: 29 · 2020: 32 · 2019: 31 · 2018: 31 · 2017: 44 · 2016: 54 · 2015: 59 · 2014: 76 · 2013: 47 · 2012: 8
FWCI
4.53
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
microRNA, p53, tumor suppression, p53 pathway, cell cycle regulation, epithelial-mesenchymal transition, cancer stemness, cancer metabolism, angiogenesis, cell survival, epigenetic modifications, cancer diagnosis, cancer therapeutics
MeSH terms
Humans, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, MicroRNAs

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