Cited by 1,275Mitochondrial Function and PathologyCellular transport and secretionIon Channels and Receptors

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An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

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Kornmann, Benoît, Currie, Erin, Collins, Sean R., Schuldiner, Maya, Nunnari, Jodi, Weissman, Jonathan S., Walter, Peter·2009·Science

DOI 10.1126/science.1175088PMC PMC2933203

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Abstract

Making Connections: Endoplasmic reticulum (ER)–mitochondria connections have been implicated in many physiological processes, including calcium homeostasis, signaling, membrane biogenesis, and apoptosis. Kornmann et al. (p. 477 , published online 25 June; see the Perspective by Wiedemann et al. ) looked for a proteinaceous link between the ER and mitochondria and, using combinations of synthetic biology and classical yeast genetics, found a protein complex that tethers the two organelles. A large-scale genetic interaction map suggests that these ER-mitochondria connections are important for interorganellar phospholipid exchange.

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Authors: Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., & Walter, P.
Affiliations: Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA.
University of California, San Francisco (US)
Howard Hughes Medical Institute (US)
Weizmann Institute of Science (IL)
University of California, Davis (US)
Corresponding author: Currie, Erin
Collins, Sean R.
ORCID: Collins, Sean R.
Schuldiner, Maya
Nunnari, Jodi
Weissman, Jonathan S.
Walter, Peter
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2009-07-24
Volume: 325
Issue: 5939
Pages: 477-481
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1175088
PMC: PMC2933203
OpenAlex: W1997527771
Cited by: 1,275
References: 32
Citations by year: 2026: 29 · 2025: 49 · 2024: 79 · 2023: 54 · 2022: 63 · 2021: 91 · 2020: 86 · 2019: 89 · 2018: 80 · 2017: 85 · 2016: 90 · 2015: 74 · 2014: 91 · 2013: 88 · 2012: 73
FWCI: 30.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
Howard Hughes Medical Institute
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
National Institutes of Health
National Institute of General Medical Sciences (R01GM062942, R01GM032384)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: ER-mitochondria tethering, inter-organelle communication, phospholipid synthesis, calcium signaling, genetic interaction mapping
MeSH terms: Animals, Endoplasmic Reticulum, Membrane Proteins, Mitochondria, Phospholipids, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Calcium Signaling, Mitochondrial Proteins, Saccharomyces cerevisiae Proteins, Mice

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An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

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