The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
Open accessAbstract
Toward Neuronal Regeneration: Neurons in the central nervous system that are severed or crushed do not regenerate well. Part of the problem derives from the glial scars left behind after such damage. The scar tissue contains sulfated proteoglycans that seem to inhibit axon regeneration. Shen et al. (p. 592 , published online 15 October) have now identified a protein tyrosine phosphatase (PTP) in mouse neuronal membranes that functions as a receptor for the proteoglycans. Neurons that lacked this particular PTP showed improved regeneration. Regeneration remained incomplete, presumably due to other inhibitory factors in the way of complete axon regeneration.
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“Specifically, CSPGs, and particularly their GAG moieties, may act by i) binding to a specific receptor; ii) blocking the growth-promoting activity of integrins; iii) presenting growth-inhibitory proteins.”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Shen et al., 2009
In the citing paper
“Known CS/CSPG receptors are: contactin-1 (Mikami et al., 2009), receptor protein tyrosine phosphatase sigma (RPTPσ; Shen et al., 2009), leukocyte common antigen-related phosphatase (LAR; Fisher et al., 2011) and Nogo receptor (NgR) 1 and 3 (Dickendesher et al., 2012).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Shen et al., 2009
In the citing paper
“RPTPσ can bind with high affinity to neurocan and aggrecan and strongly inhibits axon outgrowth and regeneration (Sapieha et al., 2005;Shen et al., 2009;Fry et al., 2010;Lang et al., 2015).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Shen et al., 2009
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Citations
Cites
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
Self-citationChondroitinase ABC promotes functional recovery after spinal cord injury
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Glial inhibition of CNS axon regeneration
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Self-citationSulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
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Self-citationRegeneration of adult axons in white matter tracts of the central nervous system
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Self-citationNeumann, S., & Woolf, C. J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80755-2 · Cited by 659
Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells
Goldberg, J. L., Klassen, M. P., Hua, Y., & Barres, B. A. (2002) · Science · doi:10.1126/science.1068428 · Cited by 488
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Self-citationNeurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes
Asher, R. A., Morgenstern, D. A., Fidler, P. S., Adcock, K. H., Oohira, A., Braistead, J. E., Levine, J. M., Margolis, R. U., ROGERS, J. H., & Fawcett, J. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02427.2000 · Cited by 482
Structural and functional recovery from early monocular deprivation in adult rats
Pizzorusso, T., Medini, P., Landi, S., Baldini, S., Berardi, N., & Maffei, L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602657103 · Cited by 367
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The Biology of Regeneration Failure and Success After Spinal Cord Injury
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Self-citationFrom basics to clinical: A comprehensive review on spinal cord injury
Silva, N. A., Sousa, N., Reis, R. L., & Salgado, A. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.002 · Cited by 838
Moving beyond the glial scar for spinal cord repair
Bradbury, E. J., & Burnside, E. R. (2019) · Nature Communications · doi:10.1038/s41467-019-11707-7 · Cited by 774
Functional regeneration beyond the glial scar
Cregg, J. M., DePaul, M. A., Filous, A. R., Lang, B. T., Tran, A. P., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.024 · Cited by 688
Self-citationSpinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses
Orr, M. B., & Gensel, J. C. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0631-6 · Cited by 596
Metadata
- Authors
- Shen, Y., Tenney, A. P., Busch, S. A., Horn, K. P., Cuascut, F. X., Liu, K., He, Z., Silver, J., & Flanagan, J. G.
- Affiliations
- Harvard University (US)
- Case Western Reserve University (US)
- Boston Children's Hospital (US)
- Corresponding author
- Shen, Yingjie
- Tenney, Alan P.
- Flanagan, John G.
- Venue
- Science
- Published
- 2009-10-23
- Volume
- 326
- Issue
- 5952
- Pages
- 592-596
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2811318
- OpenAlex
- W2043930451
- Cited by
- 682
- References
- 36
- Citations by year
- 2026: 23 · 2025: 29 · 2024: 31 · 2023: 30 · 2022: 34 · 2021: 41 · 2020: 40 · 2019: 32 · 2018: 45 · 2017: 43 · 2016: 35 · 2015: 53 · 2014: 63 · 2013: 57 · 2012: 59
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R01EY011559)
- National Institute of Neurological Disorders and Stroke (R37NS025713, R01NS025713)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD029417)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- PTPσ, chondroitin sulfate proteoglycans, axon regeneration, nerve regeneration, spinal cord injury, immunoglobulin-like domains, gene disruption, neuroprotection
- MeSH terms
- Animals, Astrocytes, Axons, Binding Sites, Cells, Cultured, Chondroitin Sulfates, Female, Ganglia, Spinal, Ligands, Nerve Regeneration, Nerve Tissue Proteins, Neurons, Protein Binding, Chondroitin Sulfate Proteoglycans, Proteoglycans, Recombinant Fusion Proteins, Spinal Cord, Spinal Cord Injuries, Neurites, Mice, Aggrecans, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Protein Interaction Domains and Motifs, Neurocan
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