Structural and functional recovery from early monocular deprivation in adult rats
Open accessAbstract
Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix with chondroitinase ABC promotes plasticity in the adult visual cortex. We tested whether chondroitinase ABC treatment of adult rats facilitates anatomical, functional, and behavioral recovery from the effects of a period of monocular deprivation initiated during the critical period for monocular deprivation. We found that chondroitinase ABC treatment coupled with reverse lid-suturing causes a complete recovery of ocular dominance, visual acuity, and dendritic spine density in adult rats. Thus, manipulations of the extracellular matrix can be used to promote functional recovery in the adult cortex.
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Maturation of the ECM and PNNs is negatively correlated with the expression of synaptic plasticity.
“The maturation of the ECM in general, and PNNs in particular, has been negatively correlated with the expression of synaptic plasticity.”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Pizzorusso et al., 2006
The rescue of structural and functional plasticity in Mmp9−/− mouse by hyaluronidase supports the assertion that degradation of the extracellular environment reactivates ocular dominance plasticity in adults.
“Nonetheless, the rescue of structural and functional plasticity in Mmp9−/− mouse by hyaluronidase supports the assertion that degradation of the extracellular environment reactivates ocular dominance plasticity in adults (Pizzorusso et al., 2002; Pizzorusso et al., 2006).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Pizzorusso et al., 2006
The decrease in spine density caused by long-term monocular deprivation is recovered by chondroitinase treatment.
“In addition, the decrease in spine density caused by long-term monocular deprivation is recovered by chondroitinase treatment (Pizzorusso et al., 2006).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Pizzorusso et al., 2006
Removal of chondroitin sulfate proteoglycans by chondroitinase in adult animals restores juvenile levels of plasticity in the rat visual cortex and allows complete recovery of visual acuity in rats that experienced monocular deprivation during the critical period.
“They showed that removal of CSPGs by chondroitinase [a bacterial enzyme which degrades GAGs, including chondroitin sulfate and hyaluronan, disrupting the structure of the perineuronal net; see Galtrey and Fawcett (2007) for review] in adult animals restores juvenile levels of plasticity in the rat visual cortex, and allow a complete recovery of visual acuity in rats which experienced monocular”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Pizzorusso et al., 2006
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Arbat-Plana, A., Torres-Espín, A., Navarro, X., & Udina, E. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.009 · Cited by 40 · see citing works
Optimization of visual training for full recovery from severe amblyopia in adults
Eaton, N. C., Sheehan, H. M., & Quinlan, E. M. (2016) · Learning & Memory · doi:10.1101/lm.040295.115 · Cited by 28 · see citing works
DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain
Hayashi, N., Tatsumi, K., Okuda, H., Yoshikawa, M., Ishizaka, S., Miyata, S., Manabe, T., & Wanaka, A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.040 · Cited by 30 · see citing works
Chemistry and Function of Glycosaminoglycans in the Nervous System
Schwartz, N. B., & Domowicz, M. S. (2014) · Advances in Neurobiology · doi:10.1007/978-1-4939-1154-7_5 · Cited by 25 · see citing works
- Authors
- Pizzorusso, T., Medini, P., Landi, S., Baldini, S., Berardi, N., & Maffei, L.
- Affiliations
- Neuroscience Institute (IT)
- Scuola Normale Superiore (IT)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-05-30
- Volume
- 103
- Issue
- 22
- Pages
- 8517-8522
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1482523
- OpenAlex
- W1986126224
- Cited by
- 367
- References
- 39
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 7 · 2023: 9 · 2022: 16 · 2021: 8 · 2020: 27 · 2019: 12 · 2018: 22 · 2017: 22 · 2016: 12 · 2015: 19 · 2014: 31 · 2013: 28 · 2012: 27
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Scuola Normale Superiore di Pisa (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- monocular deprivation, chondroitinase ABC, chondroitin sulfate proteoglycans, extracellular matrix, ocular dominance, visual acuity, dendritic spine density, critical period, functional recovery
- MeSH terms
- Aging, Animals, Behavior, Animal, Electrophysiology, Spine, Time Factors, Vision Disorders, Visual Cortex, Vision, Monocular, Chondroitin ABC Lyase, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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