The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome
Open accessAbstract
Nascent Chains Revealed: Detailed analysis of protein translation and translocation across membranes requires the identification and structural analysis of intermediates involved in these processes (see the Perspective by Kampmann and Blobel ). Seidelt et al. (p. 1412 , published online 29 October) report the visualization by cryo-electron microscopy of a nascent polypeptide chain in the tunnel of the ribosome at 5.8 angstroms. This resolution allows analysis of the conformation and distinct contacts of the nascent chain within the ribosomal tunnel, which suggests a mechanism by which translational stalling is induced by this peptide. Protein translocation across cellular membranes involves the Sec61 protein, a component of a protein-conducting channel. Whether Sec61 acts as a monomer or as an oligomer during protein translocation has been unclear. Becker et al. (p. 1369 , published online 29 October) describe active yeast and mammalian ribosome-Sec61 structures that show the Sec61 complex interacting with the ribosome and a nascent secretory protein signal sequence. The analysis unambiguously reveals that the active protein-conducting channel is a single Sec61 copy with its central pore serving as conduit for the nascent polypeptide.
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Cites
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977
Structure of a complex of the ATPase SecA and the protein-translocation channel.
Zimmer, J., Nam, Y., & Rapoport, T. A. (2008) · Nature · doi:10.1038/nature07335 · Cited by 459
Ribosome binding of a single copy of the SecY complex: implications for protein translocation.
Ménétret, J.-F., Schaletzky, J., Clemons, W. M., Osborne, A. R., Skånland, S. S., Denison, C., Gygi, S. P., Kirkpatrick, D. S., Park, E., Ludtke, S. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.10.034 · Cited by 108
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Metadata
- Authors
- Becker, T., Bhushan, S., Jarasch, A., Armache, J.-P., Funes, S., Jossinet, F., Gumbart, J., Mielke, T., Berninghausen, O., Schulten, K., Westhof, E., Gilmore, R., Mandon, E. C., & Beckmann, R.
- Venue
- Science
- Published
- 2009-12-04
- Volume
- 326
- Issue
- 5958
- Pages
- 1369-1373
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2109184486
- Cited by
- 293
- References
- 3
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Becker, T., Bhushan, S., Jarasch, A., Armache, J.-P., Funes, S., Jossinet, F., Gumbart, J., Mielke, T., Berninghausen, O., Schulten, K., Westhof, E., Gilmore, R., Mandon, E. C., & Beckmann, R. (2009). Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome. Science. https://doi.org/10.1126/science.1178535
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