The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
RACK1, A multifaceted scaffolding protein: Structure and function
Open accessAbstract
The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β subunit of G-proteins (Gβ). RACK1 adopts a seven-bladed β-propeller structure which facilitates protein binding. RACK1 has a significant role to play in shuttling proteins around the cell, anchoring proteins at particular locations and in stabilising protein activity. It interacts with the ribosomal machinery, with several cell surface receptors and with proteins in the nucleus. As a result, RACK1 is a key mediator of various pathways and contributes to numerous aspects of cellular function. Here, we discuss RACK1 gene and structure and its role in specific signaling pathways, and address how posttranslational modifications facilitate subcellular location and translocation of RACK1. This review condenses several recent studies suggesting a role for RACK1 in physiological processes such as development, cell migration, central nervous system (CN) function and circadian rhythm as well as reviewing the role of RACK1 in disease.
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Dentice, M., Bandyopadhyay, A., Gereben, B., Callebaut, I., Christoffolete, M. A., Kim, B. W., Nissim, S., Mornon, J.-P., Zavacki, A. M., Zeöld, A., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1272 · Cited by 227
Kraus, S., Gioeli, D., Vomastek, T., Gordon, V., & Weber, M. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0596 · Cited by 118
Brandon, N. J., Jovanovic, J. N., Smart, T. G., & Moss, S. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06353.2002 · Cited by 106
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Kedersha, N., Ivanov, P., & Anderson, P. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.07.004 · Cited by 631
Anton, L., Cheng, W., Haile, M. T., Dziekan, J. M., Cobb, D. W., Zhu, X., Han, L., Li, E., Nair, A., Lee, C. L., et al. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01632-3 · Cited by 21
Lee, U., Choi, C., Ryu, S. H., Park, D., Lee, S.-E., Kim, K., Kim, Y., & Chang, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011371118 · Cited by 18
Metadata
- Authors
- Adams, D. R., Ron, D., & Kiely, P. A.
- Venue
- Cell Communication and Signaling
- Published
- 2011-10-06
- Volume
- 9
- Issue
- 1
- Pages
- 22-22
- ISSN
- 1478-811X (ISSN-L)
- OpenAlex
- W2022802363
- Cited by
- 465
- References
- 3
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- gold
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- Adams, D. R., Ron, D., & Kiely, P. A. (2011). RACK1, A multifaceted scaffolding protein: Structure and function. Cell Communication and Signaling. https://doi.org/10.1186/1478-811x-9-22
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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