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A Periplasmic Reducing System Protects Single Cysteine Residues from Oxidation
Abstract
Periplasmic Redox Regulation: The oxidation state of intracellular and extracellular proteins are carefully managed by cellular redox machineries. Depuydt et al. (p. 1109 ) discovered a reducing system that protects single cysteine residues from oxidation in the bacterial periplasm. DsbG, a thioredoxin-related protein, appears to be a key player in that system and is the first reductase identified in the periplasm of Escherichia coli . Together with DsbC, DsbG controls the global sulfenic acid content of this compartment. Sulfenic acid formation is a major posttranslational modification in the periplasm, and three homologous L,D-transpeptidases are substrates of DsbG. Sulfenic acid formation is not restricted to E. coli , but is ubiquitous. Because proteins from the thioredoxin superfamily are widespread, similar thioredoxin-related proteins may control cellular sulfenic acid more widely.
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Cited by
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
Paulsen, C. E., & Carroll, K. S. (2013) · Chemical Reviews · doi:10.1021/cr300163e · Cited by 1,278
Self-citationOrchestrating Redox Signaling Networks through Regulatory Cysteine Switches
Paulsen, C. E., & Carroll, K. S. (2010) · ACS Chemical Biology · doi:10.1021/cb900258z · Cited by 476
Self-citationZhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
Sulfenic acid chemistry, detection and cellular lifetime
Gupta, V., & Carroll, K. S. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.040 · Cited by 427
Self-citationMeyer, Y., Belin, C., Delorme-Hinoux, V., Reichheld, J.-P., & Riondet, C. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4327 · Cited by 406
Metadata
- Authors
- Depuydt, M., Leonard, S. E., Vertommen, D., Denoncin, K., Morsomme, P., Wahni, K., Messens, J., Carroll, K. S., & Collet, J.-F.
- Venue
- Science
- Published
- 2009-11-20
- Volume
- 326
- Issue
- 5956
- Pages
- 1109-1111
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027572818
- Cited by
- 182
- References
- 0
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Depuydt, M., Leonard, S. E., Vertommen, D., Denoncin, K., Morsomme, P., Wahni, K., Messens, J., Carroll, K. S., & Collet, J.-F. (2009). A Periplasmic Reducing System Protects Single Cysteine Residues from Oxidation. Science. https://doi.org/10.1126/science.1179557
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