The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Selective Phenol Hydrogenation to Cyclohexanone Over a Dual Supported Pd–Lewis Acid Catalyst
Abstract
Cooperative Reduction: Selective redox transformation remains a general challenge in chemical synthesis. All too often, the most readily available precursor to a compound must be over-reduced (or over-oxidized) and then carefully coaxed back to a desired intermediate state. Such is the case with the synthesis of cyclohexanone, which is mass-produced for use in the preparation of nylon: Access by direct reduction of phenol is plagued by the rapid addition of too many hydrogen atoms to the substrate, producing an alcohol (cyclohexanol) in place of the ketone. Liu et al. (p. 1250 ) have discovered that the unexpected cooperation of supported palladium and a Lewis acid such as aluminum trichloride—two catalysts widely used alone but rarely in concert—facilitates highly selective conversion of phenol to cyclohexanone near room temperature. The key appears to be inhibition of the undesired ketone-to-alcohol reduction step by the Lewis acid.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chemical Synthesis Using Supercritical Fluids
(1999) · Wiley eBooks · doi:10.1002/9783527613687 · Cited by 731
Poliakoff, M., & Licence, P. (2007) · Nature · doi:10.1038/450810a · Cited by 400
Hydrogenation of Carbon Dioxide is Promoted by a Task‐Specific Ionic Liquid
Zhang, Z., Xie, Y., Li, W., Hu, S., Song, J., Jiang, T., & Han, B. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200704487 · Cited by 292
Self-citationHydrogenation of Carbon Dioxide is Promoted by a Task‐Specific Ionic Liquid
Zhang, Z., Xie, Y., Li, W., Hu, S., Song, J., Jiang, T., & Han, B. (2008) · Angewandte Chemie · doi:10.1002/ange.200704487 · Cited by 271
Self-citationMakowski, P., Demir Cakan, R., Antonietti, M., Goettmann, F., & Titirici, M.-M. (2008) · Chemical Communications · doi:10.1039/b717928f · Cited by 238
Continuous hydrogenation of organic compounds in supercritical fluids
Hitzler, M. G., & Poliakoff, M. (1997) · Chemical Communications · doi:10.1039/a704371f · Cited by 139
Vapor phase hydrogenation of phenol over silica supported Pd and PdYb catalysts
Shore, S. G., Ding, E., Park, C., & Keane, M. A. (2002) · Catalysis Communications · doi:10.1016/s1566-7367(02)00052-3 · Cited by 122
Hydrogenation of phenol in aqueous phase with palladium on activated carbon catalysts
Díaz, E., Mohedano, A. F., Calvo, L., Gilarranz, M. A., Casas, J. A., & Rodriguez, J. J. (2006) · Chemical Engineering Journal · doi:10.1016/j.cej.2006.12.020 · Cited by 110
Liu, L., Li, Y., Wei, H., Dong, M., Wang, J., Slawin, A. M. Z., Li, J., Dong, J., & Morris, R. E. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200804891 · Cited by 94
Li, H., Li, H., Liu, J., et al. (2008) · Advanced Functional Materials · doi:10.1002/adfm.200800667 · Cited by 91
Cited by
Iglesias, J., Martínez-Salazar, I., Maireles-Torres, P., Martin Alonso, D., Mariscal, R., & López Granados, M. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00177e · Cited by 292
Shape-controlled syntheses of rhodium nanocrystals for the enhancement of their catalytic properties
Xie, S., Liu, X. Y., & Xia, Y. (2015) · Nano Research · doi:10.1007/s12274-014-0674-x · Cited by 104
A solution for 4-propylguaiacol hydrodeoxygenation without ring saturation
Zhang, Z., Li, Q., Wu, X., Bourmaud, C., Vlachos, D. G., Luterbacher, J., Bodi, A., & Hemberger, P. (2024) · Nature Communications · doi:10.1038/s41467-024-50724-z · Cited by 13
Metadata
- Authors
- Liu, H., Jiang, T., Han, B., Liang, S., & Zhou, Y.
- Venue
- Science
- Published
- 2009-11-27
- Volume
- 326
- Issue
- 5957
- Pages
- 1250-1252
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053923926
- Cited by
- 699
- References
- 12
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Selective Phenol Hydrogenation to Cyclohexanone Over a Dual Supported Pd–Lewis Acid Catalyst. https://app.cochat.ai/papers/10.1126/science.1179713
- The paper
- Liu, H., Jiang, T., Han, B., Liang, S., & Zhou, Y. (2009). Selective Phenol Hydrogenation to Cyclohexanone Over a Dual Supported Pd–Lewis Acid Catalyst. Science. https://doi.org/10.1126/science.1179713
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
