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Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP
Open accessAbstract
Decoding a Second-Messenger's Message: Biofilms are aggregates of bacteria on a surface often associated with increased resistance to antibiotics and stress. In Vibrio cholerae , the bacterial species that causes cholera, biofilm formation is promoted by the bacterial second-messenger cyclic diguanylate (c-di-GMP) and involves the transcription regulator, VpsT. Krasteva et al. (p. 866 ) show that VpsT is itself a receptor for c-di-GMP and that binding of the small signaling molecule promotes VpsT dimerization, which is required for DNA recognition and transcriptional regulation. As well as activating components of the biofilm pathway, VpsT also down-regulates motility genes in a c-di-GMP–dependent manner.
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Cited by
Sambanthamoorthy, K., Sloup, R. E., Parashar, V., Smith, J. M., Kim, E. E., Semmelhack, M. F., Neiditch, M. B., & Waters, C. M. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01396-12 · Cited by 151
Kim, B., Park, J.-S., Choi, H.-Y., Yoon, S. S., & Kim, W.-G. (2018) · Scientific Reports · doi:10.1038/s41598-018-26974-5 · Cited by 103
The role of RNA regulators, quorum sensing and c‐di‐GMP in bacterial biofilm formation
Condinho, M., Carvalho, B., Cruz, A., Pinto, S. N., Arraiano, C. M., & Pobre, V. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13389 · Cited by 64
Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone
Li, S., Sun, H., Li, J., Zhao, Y., Wang, R., Xu, L., Duan, C., Li, J., Wang, Z., Liu, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34607-9 · Cited by 58
ComFB, a new widespread family of c-di-NMP receptor proteins
Samir, S., Elshereef, A. A., Alva, V., Hahn, J., Dubnau, D., Galperin, M. Y., & Selim, K. A. (2024) · doi:10.1101/2024.11.10.622515 · Cited by 7
Metadata
- Authors
- Krasteva, P. V., Fong, J. C. N., Shikuma, N. J., Beyhan, S., Navarro, M. V. A. S., Yildiz, F. H., & Sondermann, H.
- Venue
- Science
- Published
- 2010-02-12
- Volume
- 327
- Issue
- 5967
- Pages
- 866-868
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2096770879
- Cited by
- 399
- References
- 0
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Krasteva, P. V., Fong, J. C. N., Shikuma, N. J., Beyhan, S., Navarro, M. V. A. S., Yildiz, F. H., & Sondermann, H. (2010). Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science. https://doi.org/10.1126/science.1181185
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