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Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa
Open accessAbstract
Killing Pseudomonas: Gram-negative Pseudomonas bacteria are opportunistic pathogens, and drug-resistant strains present a serious health problem. Srinivas et al. (p. 1010 ) synthesized a family of peptidomimetic antibiotics that is active only against Pseudomonas . These antibiotics do not lyse the cell membrane, but instead target an essential outer membrane protein, LptD, which plays a role in the assembly of lipopolysaccharide in the outer cell membrane. Activity in a mouse infection model suggests that the antibiotics might have therapeutic potential. In addition, LptD is widely distributed in gram-negative bacteria and so its validation as a target has the potential to drive development of antibiotics with a broader spectrum of activity against gram-negative pathogens.
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Cites
Agents that increase the permeability of the outer membrane
Vaara, M. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.395-411.1992 · Cited by 1,879
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Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Function and Biogenesis of Lipopolysaccharides
Bertani, B., & Ruiz, N. (2018) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0001-2018 · Cited by 742
The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
de Breij, A., Riool, M., Cordfunke, R. A., Malanovic, N., de Boer, L., Koning, R. I., Ravensbergen, E., Franken, M., van der Heijde, T., Boekema, B. K., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan4044 · Cited by 555
Diazirine based photoaffinity labeling
Dubinsky, L., Krom, B. P., & Meijler, M. M. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.06.066 · Cited by 396
Metadata
- Authors
- Srinivas, N., Jetter, P., Ueberbacher, B. J., Werneburg, M., Zerbe, K., Steinmann, J., Van der Meijden, B., Bernardini, F., Lederer, A., Dias, R. L. A., Misson, P. E., Henze, H., Zumbrunn, J., Gombert, F. O., Obrecht, D., Hunziker, P., Schauer, S., Ziegler, U., Käch, A., Eberl, L., Riedel, K., DeMarco, S. J., & Robinson, J. A.
- Venue
- Science
- Published
- 2010-02-19
- Volume
- 327
- Issue
- 5968
- Pages
- 1010-1013
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034401306
- Cited by
- 554
- References
- 1
- FWCI
- 25.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Srinivas, N., Jetter, P., Ueberbacher, B. J., Werneburg, M., Zerbe, K., Steinmann, J., Van der Meijden, B., Bernardini, F., Lederer, A., Dias, R. L. A., Misson, P. E., Henze, H., Zumbrunn, J., Gombert, F. O., Obrecht, D., Hunziker, P., Schauer, S., Ziegler, U., Käch, A., . . . Robinson, J. A. (2010). Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa. Science. https://doi.org/10.1126/science.1182749
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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