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Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment
Open accessAbstract
Sperm Production-Line Maintenance: The average man makes upwards of 1500 sperm per heartbeat. Such a feat requires a robust stem cell system. Using mice, Nakagawa et al. (p. 62 , published online 18 March) shed light on some of the properties of the murine germline stem cell system that contribute to its robustness. During steady-state spermatogenesis, the majority of the stem cell population lies within a subset of cells called type A spermatogonia. However, during regeneration (for example, during recovery of the stem cell pool after drug exposure) the system in essence hijacks early-differentiating cells back into the stem cell compartment. Lineage analysis and live-imaging also suggests that during sperm production there is more than one path from a stem cell to differentiation.
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Citations
Cited by
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Guo, J., Grow, E. J., Mlcochova, H., Maher, G. J., Lindskog, C., Nie, X., Guo, Y., Takei, Y., Yun, J., Cai, L., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0099-2 · Cited by 710
The Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 513
Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
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Merrell, A. J., & Stanger, B. Z. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.24 · Cited by 369
CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
Ventelä, S., Côme, C., Mäkelä, J.-A., Hobbs, R. M., Mannermaa, L., Kallajoki, M., Chan, E. K., Pandolfi, P. P., Toppari, J., & Westermarck, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033209 · Cited by 58
Metadata
- Authors
- Nakagawa, T., Sharma, M., Nabeshima, Y.-I., Braun, R. E., & Yoshida, S.
- Venue
- Science
- Published
- 2010-04-02
- Volume
- 328
- Issue
- 5974
- Pages
- 62-67
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997919787
- Cited by
- 472
- References
- 0
- FWCI
- 43.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Nakagawa, T., Sharma, M., Nabeshima, Y.-I., Braun, R. E., & Yoshida, S. (2010). Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment. Science. https://doi.org/10.1126/science.1182868
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