The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae
Open accessAbstract
Mosquito Double Act: Peroxidase/dual oxidase (duox) systems act in concert to catalyze the nonspecific formation of dityrosine bonds, which cross-link a variety of proteins. Knowing that these reactions are involved in fine-tuning insect immune responses, Kumar et al. (p. 1644 , published online 11 March) investigated how the peroxidase/duox system in malaria-vector mosquitoes protects the gut flora by modulating midgut antibacterial responses. Generating immune reactions resulted in a loss of mosquito egg viability, but modulating host responses allowed malaria parasites to persist among the surviving commensal flora. The peroxidase/duox system appears to promote dityrosine bond formation between proteins across the surface of midgut epithelial cells to form a layer that inhibits immune recognition and mediator release. Interference with the formation of this layer might provide a target for mosquito and malaria control.
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Edens, W. A., Sharling, L., Cheng, G., Shapira, R., Kinkade, J. M., Lee, T., Edens, H. A., Tang, X., Sullards, C., Flaherty, D. B., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103132 · Cited by 375
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Crompton, P. D., Moebius, J., Portugal, S., Waisberg, M., Hart, G., Garver, L. S., Miller, L. H., Barillas-Mury, C., & Pierce, S. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120220 · Cited by 317
Self-citationA Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses
Wu, P., Sun, P., Nie, K., Zhu, Y., Shi, M., Xiao, C., Liu, H., Liu, Q., Zhao, T., Chen, X., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.004 · Cited by 267
Antimicrobial actions of dual oxidases and lactoperoxidase
Sarr, D., Tóth, E., Gingerich, A., & Rada, B. (2018) · Journal of Microbiology · doi:10.1007/s12275-018-7545-1 · Cited by 98
Strengert, M., Jennings, R., Davanture, S., Hayes, P., Gabriel, G., & Knaus, U. G. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5353 · Cited by 88
Metadata
- Authors
- Kumar, S., Molina-Cruz, A., Gupta, L., Rodrigues, J., & Barillas-Mury, C.
- Venue
- Science
- Published
- 2010-03-26
- Volume
- 327
- Issue
- 5973
- Pages
- 1644-1648
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060266444
- Cited by
- 333
- References
- 1
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Kumar, S., Molina-Cruz, A., Gupta, L., Rodrigues, J., & Barillas-Mury, C. (2010). A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae. Science. https://doi.org/10.1126/science.1184008
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