The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
RIGorous Detection: Exposing Virus Through RNA Sensing
Abstract
Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I–like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“They are attached to their neighbors by cell-cell junctions, including tight junctions (TJs), adherens junctions (AJs), gap junctions, and desmosomes (234).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [234]
Citations
Cites
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
5'-Triphosphate RNA Is the Ligand for RIG-I
Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science · doi:10.1126/science.1132505 · Cited by 2,474
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210
Kato, H., Takeuchi, O., Mikamo, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T. S., Fujita, T., & Akira, S. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080091 · Cited by 1,649
RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185
Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892
Schlee, M., Roth, A. H. F. J., Hornung, V., Hagmann, C. A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.008 · Cited by 814
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
Saito, T., Owen, D. M., Jiang, F., Marcotrigiano, J., & Gale, M. (2008) · Nature · doi:10.1038/nature07106 · Cited by 737
Pichlmair, A., & Sousa, C. R. E. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.012 · Cited by 690
Small self-RNA generated by RNase L amplifies antiviral innate immunity
Malathi, K., Dong, B., Gale, M., & Silverman, R. H. (2007) · Nature · doi:10.1038/nature06042 · Cited by 663
Poeck, H., Bscheider, M., Groß, O., Finger, K., Roth, S., Rebsamen, M., Hannesschläger, N., Schlee, M., Rothenfußer, S., Barchet, W., et al. (2009) · Nature Immunology · doi:10.1038/ni.1824 · Cited by 534
The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I
Cui, S., Eisenächer, K., Kirchhofer, A., Brzózka, K. D., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K., Krug, A., & Hopfner, K. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.10.032 · Cited by 509
Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses
Takahasi, K., Yoneyama, M., Nishihori, T., Hirai, R., Kumeta, H., Narita, R., Gale, M., Inagaki, F., & Fujita, T. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.028 · Cited by 474
Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
Pichlmair, A., Schulz, O., Tan, C.-P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., & Sousa, C. R. E. (2009) · Journal of Virology · doi:10.1128/jvi.00770-09 · Cited by 469
Self-citation5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
Schmidt, A., Schwerd, T., Hamm, W., Hellmuth, J. C., Cui, S., Wenzel, M., Hoffmann, F. S., Michallet, M.-C., Besch, R., Hopfner, K.-P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900971106 · Cited by 398
Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate–Dependent Translocase on Double-Stranded RNA
Myong, S., Cui, S., Cornish, P. V., Kirchhofer, A., Gack, M. U., Jung, J. U., Hopfner, K., & Ha, T. (2009) · Science · doi:10.1126/science.1168352 · Cited by 368
Habjan, M., Andersson, I., Klingström, J., Schümann, M., Arnold, M., Zimmermann, P., Wagner, V., Pichlmair, A., Schneider, U., Mühlberger, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002032 · Cited by 331
Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response
Maines, T. R., Szretter, K. J., Perrone, L. A., Belser, J. A., Bright, R. A., Zeng, H., Tumpey, T. M., & Katz, J. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00690.x · Cited by 172
Agonist and Antagonist Recognition by RIG-I, a Cytoplasmic Innate Immunity Receptor
Ranjith-Kumar, C. T., Murali, A., Dong, W., Dharmaiah, S., Vaughan, R. C., Ortiz-Alcántara, J. M., Bhardwaj, K., Li, X., Li, P., & Kao, C. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806219200 · Cited by 61
Flagged first, then by citations
Research works printed but not linked: 1
- D. M. Knipe P. M. Howley Fields’ Virology (Lippincott Williams & Wilkins Philadelphia ed. 5 2007).
Cited by
Sorted by citations
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
Tanaka, Y., & Chen, Z. J. (2012) · Science Signaling · doi:10.1126/scisignal.2002521 · Cited by 1,357
Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,306
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
“It has become apparent that viral RNA is also detected by intracellular viral sensors such as RIG-I and melanoma differentiation-associated gene 5 (MDA5), both of which are members of the RIG-I-like RNA helicase family (231).”
BackgroundEpithelial crosstalk at the microbiota–mucosal interface
Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574
“The ubiquitously expressed RIGI-like receptor (RLR) family of RNA helicases are cytoplasmic proteins that recognize viral RNAs and induce innate antiviral responses, including the activation of proinflammatory cytokines and type I interferon (IFN) (10).”
BackgroundZhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X., & Chen, Z. J. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.003 · Cited by 505
Metadata
- Authors
- Rehwinkel, J., & Reis e Sousa, C.
- Affiliations
- Cancer Research UK (GB)
- Immunobiology Laboratory, Cancer Research UK (CRUK) London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK.
- ORCID
- Rehwinkel, Jan
- Venue
- Science
- Published
- 2010-01-15
- Volume
- 327
- Issue
- 5963
- Pages
- 284-286
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006928776
- Cited by
- 163
- References
- 19
- Citations by year
- 2024: 1 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 12 · 2015: 9 · 2014: 16 · 2013: 12 · 2012: 12
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- RIG-I-like receptors, RNA sensing, antiviral innate immunity, RNA helicase, virus detection, host-virus interaction, RIG-I, MDA5, LGP2
- MeSH terms
- DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Animals, Humans, Immunity, Innate, Interferons, Nucleic Acid Conformation, RNA Virus Infections, RNA Viruses, RNA, Double-Stranded, RNA, Viral, Viral Proteins, Signal Transduction, Genome, Viral, Protein Structure, Tertiary, Base Pairing, Receptors, Pattern Recognition, DEAD-box RNA Helicases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
