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Cited by 732

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Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures

Percec, Virgil, Wilson, Daniela A., Leowanawat, Pawaret, Wilson, Christopher J., Hughes, Andrew D., Kaucher, Mark S., Hammer, Daniel A., Levine, Dalia H., Kim, Anthony J., Bates, Frank S., Davis, Kevin P., Lodge, Timothy P., Klein, Michael L., DeVane, Russell H., Aqad, Emad, Rosen, Brad M., Argintaru, Andreea O., Sienkowska, Monika J., Rissanen, Kari, Nummelin, Sami, Ropponen, Jarmo·2010·Science

Abstract

Janus Drug Delivery Vehicle: Efficient drug delivery vehicles need to be produced in a limited size range and with uniform size distribution. The self-assembly of traditional small-molecule and polymeric amphiphiles has led to the production of micelles, liposomes, polymeric micelles, and polymersomes for use in drug delivery applications. Now, Percec et al. (p. 1009 ) describe the self-assembly of Janus-type (i.e., two-headed) dendrimers to produce monodisperse supramolecular constructs, termed “dendrimersomes,” and other complex architectures. The structures, which showed long-term stability as well as very narrow size distributions, were easily produced by the injection of an ethanolic solution of the dendrimer into water. The dendrimersomes could be loaded with the anticancer drug doxorubicin and exhibited controlled drug release with changing pH.

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Metadata

Authors
Percec, V., Wilson, D. A., Leowanawat, P., Wilson, C. J., Hughes, A. D., Kaucher, M. S., Hammer, D. A., Levine, D. H., Kim, A. J., Bates, F. S., Davis, K. P., Lodge, T. P., Klein, M. L., DeVane, R. H., Aqad, E., Rosen, B. M., Argintaru, A. O., Sienkowska, M. J., Rissanen, K., Nummelin, S., & Ropponen, J.
Venue
Science
Published
2010-05-21
Volume
328
Issue
5981
Pages
1009-1014
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1988260329
Cited by
732
References
4
FWCI
54.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures. https://app.cochat.ai/papers/10.1126/science.1185547
The paper
Percec, V., Wilson, D. A., Leowanawat, P., Wilson, C. J., Hughes, A. D., Kaucher, M. S., Hammer, D. A., Levine, D. H., Kim, A. J., Bates, F. S., Davis, K. P., Lodge, T. P., Klein, M. L., DeVane, R. H., Aqad, E., Rosen, B. M., Argintaru, A. O., Sienkowska, M. J., Rissanen, K., . . . Ropponen, J. (2010). Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures. Science. https://doi.org/10.1126/science.1185547

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.