Liposome application: problems and prospects.
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The un-ionized forms of gradient-forming salts (e.g., acetic acid) permeate the liposome lipid bilayer faster than their ionized forms.
“The degree of ionization of these compounds is pH dependent, and their ionized species (i.e., ammonium and acetate) have a very low permeability coefficient and octanol-to-buffer partition coefficient; therefore they either do not, or only very slowly, permeate the liposome lipid bilayer, while their un-ionized species have high permeability, as well as octanol-to-buffer partition coefficient (exe”
From Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids (2011) · cites this paper as [20]
The magnitude of the intraliposome-high/extraliposome-low transmembrane ion gradient is the driving force for remote loading.
“The magnitude of the intraliposome high/external medium low transmembrane gradient of such ions is the driving force for remote loading, as they can be exchanged with amphipathic drugs that are weak acids or bases.”
From Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids (2011) · cites this paper as [20]
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Self-citation
- Authors
- Barenholz, Y.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Barenholz, Yechezkel
- ORCID
- Barenholz, Yechezkel
- Venue
- Current Opinion in Colloid & Interface Science
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 6
- Issue
- 1
- Pages
- 66-77
- ISSN
- 1359-0294 (ISSN-L)
- OpenAlex
- W1980422006
- Cited by
- 659
- References
- 65
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 22 · 2023: 18 · 2022: 27 · 2021: 24 · 2020: 27 · 2019: 28 · 2018: 29 · 2017: 29 · 2016: 35 · 2015: 32 · 2014: 45 · 2013: 39 · 2012: 32
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Colloid & Interface Science (publishedVersion)
- Funders
- Israel Science Foundation
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- liposomes, steric stabilization, lipoplexes, cationic liposomes, controlled drug release, drug loading, blood-brain barrier, skin permeation, active targeting
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