The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A Gating Charge Transfer Center in Voltage Sensors
Open accessAbstract
Open and Closed Case: Voltage-dependent ion channels are gated by voltage sensors that show a switchlike response to voltage differences across the membrane. Tao et al. (p. 67 ; see the cover) used mutagenesis, electrophysiology, and x-ray crystallography to gain insight into the molecular basis of this response in voltage-dependent potassium channels. An occluded site was identified that catalyzes translation of positive charges across the membrane. The closed channel appears to be associated with a distribution of conformations, depending on the degree of hyperpolarization of the membrane, whereas the open channel appears to be associated with a specific conformation. Thus, the transition of the ion channel from open to closed occurs over a very small voltage difference.
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Cites
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel
Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116269 · Cited by 2,124
Self-citationX-ray structure of a voltage-dependent K+ channel
Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B. T., & MacKinnon, R. (2003) · Nature · doi:10.1038/nature01580 · Cited by 1,797
Self-citationAtomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
Long, S. B., Tao, X., Campbell, E. B., & MacKinnon, R. (2007) · Nature · doi:10.1038/nature06265 · Cited by 1,411
Self-citationVoltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling
Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116270 · Cited by 979
Self-citationThe principle of gating charge movement in a voltage-dependent K+ channel
Jiang, Y., Ruta, V., Chen, J., Lee, A., & MacKinnon, R. (2003) · Nature · doi:10.1038/nature01581 · Cited by 781
Self-citationCharge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels
Armstrong, C. M., & Bezanilla, F. (1974) · The Journal of General Physiology · doi:10.1085/jgp.63.5.533 · Cited by 741
Contribution of the S4 Segment to Gating Charge in the Shaker K+ Channel
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Self-citationPhosphoinositide phosphatase activity coupled to an intrinsic voltage sensor
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Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel
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A voltage-gated proton-selective channel lacking the pore domain
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Metadata
- Authors
- Tao, X., Lee, A., Limapichat, W., Dougherty, D. A., & MacKinnon, R.
- Venue
- Science
- Published
- 2010-04-02
- Volume
- 328
- Issue
- 5974
- Pages
- 67-73
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2154420373
- Cited by
- 465
- References
- 24
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
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