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c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
Open accessAbstract
Bacterial (Interferon)ce: Intracellular bacterial pathogens, such as Listeria monocytogenes , are detected in the cytosol of host immune cells, where they induce a host response that is often dependent on microbial secretion systems. Woodward et al. (p. 1703 , published online 27 May) now show that L. monocytogenes produce and release cyclic diadenosine monophosphate into the host cytosol, which induces the production of host type I interferon. Because a number of intracellular pathogens contain the protein machinery to generate this nucleotide and also activate this same innate immune pathway, a common molecular mechanism may exist for host detection of cytosolic bacterial pathogens.
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Citations
Cited by
Molecular mechanisms and cellular functions of cGAS–STING signalling
Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y.-T., Grishin, N. V., et al. (2015) · Science · doi:10.1126/science.aaa2630 · Cited by 1,927
STING is a direct innate immune sensor of cyclic di-GMP
Burdette, D. L., Monroe, K. M., Sotelo-Troha, K., Iwig, J. S., Eckert, B., Hyodo, M., Hayakawa, Y., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10429 · Cited by 1,570
Corrales, L., Glickman, L. H., McWhirter, S. M., Kanne, D. B., Sivick, K. E., Katibah, G. E., Woo, S.-R., Lemmens, E., Banda, T., Leong, J. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.031 · Cited by 1,560
STING: infection, inflammation and cancer.
Barber, G. N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3921 · Cited by 1,313
Metadata
- Authors
- Woodward, J. J., Iavarone, A. T., & Portnoy, D. A.
- Venue
- Science
- Published
- 2010-06-25
- Volume
- 328
- Issue
- 5986
- Pages
- 1703-1705
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039390702
- Cited by
- 810
- References
- 0
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Woodward, J. J., Iavarone, A. T., & Portnoy, D. A. (2010). c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response. Science. https://doi.org/10.1126/science.1189801
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