RETRACTED: Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
Open accessAbstract
UnSIRT6ain Repair: Efficient and accurate repair of double-strand DNA breaks is critical for genome stability and involves a process known as homologous recombination. During repair of the sheared ends, the DNA must be resected by trimming one of the two strands on either side of the break. For the repair to be accurate, the remaining single-stranded DNA (ssDNA) has to be bound by the ssDNA-binding protein, RPA, after which the ssDNA can then bind homologous sequences. Kaidi et al. (p. 1348 ) found that the mammalian deacetylase, SIRT6 (which has been implicated in maintaining genome stability), was critical for resection. At sites of DNA damage, SIRT6 deacetylated and activated CtIP (a protein important for resection), ensuring that resection occurred at the appropriate place and time.
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SIRT6 promotes DNA double strand break repair, regulates telomere stability, suppresses inflammation and opposes tumorigenesis.
“SIRT6 promotes DNA double strand break repair19,20, regulates telomere stability21, suppresses inflammation22 and opposes tumorigenesis23,24.”
From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [20]
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References 23 · Cited by 366
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- [1]Wyman C Kanaar R Annu Rev Genet 2006 40 363 16895466
- [2]Sung P Klein H Nat Rev Mol Cell Biol 10 2006 7 739 16926856
- [3]Huertas P Nat Struct Mol Biol 1 2010 17 11 20051983 PMC2850169
- [4]Mimitou EP Symington LS DNA Repair (Amst) 2 9 2009 8 983 19473888 PMC2760233
- [5]Sartori AA Nature 22 11 2007 450 509 17965729 PMC2409435
- [7]Chen L Nievera CJ Lee AY Wu X J Biol Chem 21 3 2008 283 7713 18171670
- [8]Jackson SP Bartek J Nature 22 10 2009 461 1071 19847258 PMC2906700
- [9]Lavu S Boss O Elliott PJ Lambert PD Nat Rev Drug Discov 10 2008 7 841 18827827
- [10]Yang XJ Seto E Nat Rev Mol Cell Biol 3 2008 9 206 18292778 PMC2667380
- [11]Huertas P Jackson SP J Biol Chem 3 4 2009 284 9558 19202191 PMC2666608
- [12]Pierce AJ Hu P Han M Ellis N Jasin M Genes Dev 15 12 2001 15 3237 11751629 PMC312854
- [13]Michishita E Park JY Burneskis JM Barrett JC Horikawa I Mol Biol Cell 10 2005 16 4623 16079181 PMC1237069
- [15]Wang RH Cancer Cell 7 10 2008 14 312 18835033 PMC2643030
- [16]Lombard DB Schwer B Alt FW Mostoslavsky R J Intern Med 2 2008 263 128 18226091 PMC2486832
- [17]Michishita E Nature 27 3 2008 452 492 18337721 PMC2646112
- [19]Bryant HE Nature 14 4 2005 434 913 15829966
- [20]Farmer H Nature 14 4 2005 434 917 15829967
- [21]McCord RA Aging (Albany NY) 1 2009 1 109 20157594 PMC2815768
- [22]Yu X Wu LC Bowcock AM Aronheim A Baer R J Biol Chem 25 9 1998 273 25388 9738006
- [23]Kawahara TL Cell 9 1 2009 136 62 19135889 PMC2757125
- Authors
- Kaidi, A., Weinert, B. T., Choudhary, C., & Jackson, S. P.
- Affiliations
- University of Cambridge (GB)
- University of Copenhagen (DK)
- Corresponding author
- Jackson, Stephen P.
- Venue
- Science
- Published
- 2010-09-10
- Volume
- 329
- Issue
- 5997
- Pages
- 1348-1353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3276839
- OpenAlex
- W2041552603
- Cited by
- 366
- References
- 23
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 15 · 2019: 20 · 2018: 29 · 2017: 36 · 2016: 43 · 2015: 41 · 2014: 33 · 2013: 40 · 2012: 42
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust
- Cancer Research UK (11224, A5290)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- SIRT6, CtIP, DNA end resection, DNA double-strand break repair, homologous recombination, protein deacetylation, replication protein A, single-stranded DNA, genome stability, sirtuins, retraction
- MeSH terms
- Acetylation, Animals, Camptothecin, Carrier Proteins, Cell Cycle, Cell Line, DNA, DNA Repair, DNA, Single-Stranded, Endodeoxyribonucleases, Humans, Niacinamide, Nuclear Proteins, Protein Binding, Recombination, Genetic, Sirtuins, Genomic Instability, Cell Line, Tumor, Cell Proliferation, Mutant Proteins, Mice, DNA Breaks, Double-Stranded
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