The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins
Open accessAbstract
Cellular Devices: Cellular control mechanisms might offer opportunities to build genetic devices capable of sensing aberrant cells and activate a regulatory signal that directs the cell to alter its biological state. Culler et al. (p. 1251 ; see the Perspective by Liu and Arkin ) present a proof of principle for a synthetic gene network in which cells were engineered to make an RNA-based device that detected molecules associated with disease states such as inflammation and cancer. Detection then triggered expression of a gene that made the cells more sensitive to a drug causing cell death.
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Cites
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Synthetic biology: applications come of age
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Understanding alternative splicing: towards a cellular code
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Cited by
Programmable single-cell mammalian biocomputers
Ausländer, S., Ausländer, D., Müller, M., Wieland, M., & Fussenegger, M. (2012) · Nature · doi:10.1038/nature11149 · Cited by 375
Biomolecular computing systems: principles, progress and potential
Benenson, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3197 · Cited by 373
Designing cell function: assembly of synthetic gene circuits for cell biology applications
Xie, M., & Fussenegger, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0024-z · Cited by 285
Synthetic biology in mammalian cells: next generation research tools and therapeutics
Lienert, F., Lohmueller, J. J., Garg, A., & Silver, P. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3738 · Cited by 280
Courbet, A., Endy, D., Renard, E., Molina, F., & Bonnet, J. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3601 · Cited by 266
Metadata
- Authors
- Culler, S. J., Hoff, K. G., & Smolke, C. D.
- Venue
- Science
- Published
- 2010-11-26
- Volume
- 330
- Issue
- 6008
- Pages
- 1251-1255
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030193551
- Cited by
- 269
- References
- 29
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- green
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