HDL miR -ed Down by SREBP Introns
Open accessAbstract
MicroRNAs that reduce cholesterol export from cells are encoded in the same genes that increase cholesterol synthesis.
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Srebp-1c is transcribed at extremely high levels in response to insulin.
“By contrast, Srebp-1c is transcribed at extremely high levels in response to insulin (6, 28)”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [28]
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References 12 · Cited by 43
Research works printed but not linked: 11
- [1]Najafi -Shoushtari SH Science 328 1566 2010 published online 13 May 2010 (10.1126/science. 1189123) 20466882 PMC3840500 · DOI · Paper page
- [2]Rayner KJ Science 328 1570 2010 published online 13 May 2010 (10.1126/science.1189862) 20466885 PMC3114628 · DOI · Paper page
- [3]Brown MS Goldstein JL Cell 89 331 1997 9150132
- [4]Horton JD Goldstein JL Brown MS J Clin Invest 109 1125 2002 11994399 PMC150968
- [5]Attie AD Trends Biochem Sci 32 172 2007 17324574
- [6]Kunte AS Matthews KA Rawson RB Cell Metab 3 439 2006 16753579
- [7]Shimomura I Shimano H Horton JD Goldstein JL Brown MS J Clin Invest 99 838 1997 9062340 PMC507890
- [8]Repa JJ Genes Dev 14 2819 2000 11090130 PMC317055
- [9]Chen G Liang G Ou J Goldstein JL Brown MS Proc Natl Acad Sci USA 101 11245 2004 15266058 PMC509189
- [10]Reaven GM Cell Metab 1 9 2005 16054040
- [11]Kennedy AJ Ellacott KLJ King VL Hasty AH Dis Model Mech 3 156 2010 20212084 PMC2869491
- Authors
- Brown, M. S., Ye, J., & Goldstein, J. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Science
- Published
- 2010-06-18
- Volume
- 328
- Issue
- 5985
- Pages
- 1495-1496
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2936826
- OpenAlex
- W2047748669
- Cited by
- 43
- References
- 12
- Citations by year
- 2023: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- microRNA, SREBP, introns, HDL cholesterol, cholesterol export, cholesterol biosynthesis, microRNA biogenesis, lipid metabolism
- MeSH terms
- Animals, Cholesterol, Gene Expression Regulation, Humans, Hyperinsulinism, Introns, Lipoproteins, HDL, Liver, RNA, Messenger, Transcription, Genetic, ATP-Binding Cassette Transporters, Metabolic Syndrome, MicroRNAs, Sterol Regulatory Element Binding Protein 1, Sterol Regulatory Element Binding Protein 2, ATP Binding Cassette Transporter 1
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