The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.
Open accessAbstract
The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide reverse transcriptase inhibitor, for the prevention of HIV acquisition in women. A double-blind, randomized controlled trial was conducted comparing tenofovir gel (n = 445 women) with placebo gel (n = 444 women) in sexually active, HIV-uninfected 18- to 40-year-old women in urban and rural KwaZulu-Natal, South Africa. HIV serostatus, safety, sexual behavior, and gel and condom use were assessed at monthly follow-up visits for 30 months. HIV incidence in the tenofovir gel arm was 5.6 per 100 women-years (person time of study observation) (38 out of 680.6 women-years) compared with 9.1 per 100 women-years (60 out of 660.7 women-years) in the placebo gel arm (incidence rate ratio = 0.61; P = 0.017). In high adherers (gel adherence > 80%), HIV incidence was 54% lower (P = 0.025) in the tenofovir gel arm. In intermediate adherers (gel adherence 50 to 80%) and low adherers (gel adherence < 50%), the HIV incidence reduction was 38 and 28%, respectively. Tenofovir gel reduced HIV acquisition by an estimated 39% overall, and by 54% in women with high gel adherence. No increase in the overall adverse event rates was observed. There were no changes in viral load and no tenofovir resistance in HIV seroconverters. Tenofovir gel could potentially fill an important HIV prevention gap, especially for women unable to successfully negotiate mutual monogamy or condom use.
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“Adherence can be low (48), and prevention of HIV infection, especially among women, has not been demonstrated (47,49).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [47]
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“Tenofovir gel has been studied for prevention of herpes simplex virus 2 (HSV-2) and HIV infections (46,47).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [47]
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Cites
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Prevention of SIV Infection in Macaques by ( R )-9-(2-Phosphonylmethoxypropyl)adenine
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Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
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- R. S. Brown D. Goodwin S. Zhang E. Fagan paper presented at the 13th International Symposium on Viral Hepatitis and Liver Disease (ISVHLD) Washington DC 20 to 24 March 2009.
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The effect of the vaginal diaphragm and lubricant gel on acquisition of HSV-2.
de Bruyn, G., Shiboski, S., van der Straten, A., Blanchard, K., Chipato, T., Ramjee, G., Montgomery, E., Padian, N., & for the MIRA team (2011) · Sexually Transmitted Infections · doi:10.1136/sti.2010.047142 · Cited by 16
Sexual Relationship Power and Malnutrition Among HIV-Positive Women in Rural Uganda
Siedner, M. J., Tsai, A. C., Dworkin, S., Mukiibi, N. F. B., Emenyonu, N. I., Hunt, P. W., Haberer, J. E., Martin, J. N., Bangsberg, D. R., & Weiser, S. D. (2012) · AIDS and Behavior · doi:10.1007/s10461-012-0162-9 · Cited by 18
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Sustainability of Evidence-Based Practices for HIV Prevention among Female Sex Workers in Mexico
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Pillay, D., & Wassenaar, D. R. (2018) · South African Journal of Psychology · doi:10.1177/0081246317708094 · Cited by 6
Metadata
- Authors
- Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., Kharsany, A. B. M., Sibeko, S., Mlisana, K. P., Omar, Z., Gengiah, T. N., Maarschalk, S., Arulappan, N., Mlotshwa, M., Morris, L., Taylor, D., & on behalf of the CAPRISA 004 Trial Group
- Affiliations
- Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban 4013, South Africa.
- Centre for the AIDS Programme of Research in South Africa (ZA)
- National Institute for Communicable Diseases (ZA)
- Family Health International 360 (US)
- ORCID
- Venue
- Science
- Published
- 2010-09-03
- Volume
- 329
- Issue
- 5996
- Pages
- 1168-1174
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3001187
- OpenAlex
- W2146634980
- Cited by
- 2,435
- References
- 33
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 29 · 2023: 27 · 2022: 43 · 2021: 81 · 2020: 65 · 2019: 81 · 2018: 106 · 2017: 150 · 2016: 182 · 2015: 212 · 2014: 292 · 2013: 328 · 2012: 385
- FWCI
- 229.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- ResearchSpace (University of KwaZulu-Natal) (submittedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute of Allergy and Infectious Diseases (U01AI046749, U01AI068633, U19AI051794, U01AI068619, AI 51794)
- Fogarty International Center (D43TW000231)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- tenofovir gel, HIV prevention, microbicides, vaginal gel, women, HIV incidence, antiretroviral drugs, nucleotide reverse transcriptase inhibitors, HIV seroconversion, tenofovir resistance, sexual behavior, condom use
- MeSH terms
- Tenofovir, Adenine, Administration, Intravaginal, Adolescent, Adult, Anti-Infective Agents, Local, Double-Blind Method, Female, Humans, Patient Compliance, Pregnancy, Pregnancy Outcome, Rural Population, Sexual Behavior, South Africa, Urban Population, Vaginal Creams, Foams, and Jellies, HIV-1, HIV Infections, Incidence, Anti-HIV Agents, Viral Load, Drug Resistance, Viral, Young Adult, Organophosphonates
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