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Impeding Xist Expression from the Active X Chromosome Improves Mouse Somatic Cell Nuclear Transfer
Abstract
Cloning Futures: Cloning mammals by somatic cell nuclear transfer is a technique with many potential applications in regenerative medicine, agriculture, and pharmaceutics; however, it is inefficient because of the incidence of aberrant genomic reprogramming. Inoue et al. (p. 496 , published online 16 September) found that the gene product of Xist , which normally inactivates one of the two X chromosomes in females, was unexpectedly expressed ectopically from active X chromosomes in cloned mice. When Xist was deleted from the mice, gene expression returned to normal and the efficiency of somatic cell nuclear transfer increased about ninefold, offering promise for future nuclear transfer technology.
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Cited by
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Insights into epigenetic patterns in mammalian early embryos
Xu, R., Li, C., Liu, X., & Gao, S. (2021) · Protein & Cell · doi:10.1007/s13238-020-00757-z · Cited by 216
Molecular features of cellular reprogramming and development
Smith, Z. D., Sindhu, C., & Meissner, A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.6 · Cited by 155
Wei, J., Antony, J., Meng, F., MacLean, P., Rhind, R., Laible, G., & Oback, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-06569-2 · Cited by 39
Metadata
- Authors
- Inoue, K., Kohda, T., Sugimoto, M., Sado, T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A. P., Tian, X. C., Yang, X., Ishino, F., Abe, K., & Ogura, A.
- Venue
- Science
- Published
- 2010-10-22
- Volume
- 330
- Issue
- 6003
- Pages
- 496-499
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050608300
- Cited by
- 235
- References
- 0
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Impeding Xist Expression from the Active X Chromosome Improves Mouse Somatic Cell Nuclear Transfer. https://app.cochat.ai/papers/10.1126/science.1194174
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- Inoue, K., Kohda, T., Sugimoto, M., Sado, T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A. P., Tian, X. C., Yang, X., Ishino, F., Abe, K., & Ogura, A. (2010). Impeding Xist Expression from the Active X Chromosome Improves Mouse Somatic Cell Nuclear Transfer. Science. https://doi.org/10.1126/science.1194174
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
