The DOI matches its Crossref record; 265 of the 265 references it cites were found in a registry or an index.
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
Abstract
Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and transcribed but never get translated into proteins. Though not translated into proteins, ncRNAs play pivotal roles in a variety of cellular functions. Here, we review the functions of long noncoding RNAs (lncRNAs) and their implications in various human diseases. Increasing numbers of studies demonstrate that lncRNAs play critical roles in regulation of protein‐coding genes, maintenance of genomic integrity, dosage compensation, genomic imprinting, mRNA processing, cell differentiation, and development. Misregulation of lncRNAs is associated with a variety of human diseases, including cancer, immune and neurological disorders. Different classes of lncRNAs, their functions, mechanisms of action, and associations with different human diseases are summarized in detail, highlighting their as yet untapped potential in therapy.
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Cites
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Cited by
Long non-coding RNAs as emerging regulators of differentiation, development, and disease
Dey, B. K., Mueller, A. C., & Dutta, A. (2014) · Transcription · doi:10.4161/21541272.2014.944014 · Cited by 324
Long noncoding RNAs: functions and mechanisms in colon cancer
Chen, S., & Shen, X. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01287-2 · Cited by 313
Metadata
- Authors
- Bhan, A., & Mandal, S. S.
- Venue
- ChemMedChem
- Publisher
- Wiley
- Published
- 2014-03-26
- Volume
- 9
- Issue
- 9
- Pages
- 1932-1956
- ISSN
- 1860-7179 (ISSN-L)
- 1860-7187
- OpenAlex
- W2067337865
- Cited by
- 279
- References
- 265
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- closed
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