The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation
Open accessAbstract
A Safety Catch on Immune Response: The complement system is an integral part of the innate immune system. When triggered, it initiates a cascade that marks intruders for elimination and stimulates immune responses. The key amplification step is cleavage of a complex comprising the complement fragment C3b and factor B (C3bB) by factor D (FD). Forneris et al. (p. 1816 ) now describe the crystal structure of C3bB and its complex with FD. The structures support a mechanism in which membrane-bound C3b stabilizes an open form of factor B (FB) that has its scissile bond accessible. FD binds through a site distant from its catalytic center to the open form of FB, which activates FD. The two conformational equilibria represent a double safety-catch that would allow tight regulation of this immune response pathway.
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Cites
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
Self-citationWalport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,927
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Complement and its role in innate and adaptive immune responses
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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Xiao, T., Takagi, J., Coller, B. S., Wang, J.-H., & Springer, T. A. (2004) · Nature · doi:10.1038/nature02976 · Cited by 846
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The Membrane Attack Complex of Complement
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Complement-targeted therapeutics
Ricklin, D., & Lambris, J. D. (2007) · Nature Biotechnology · doi:10.1038/nbt1342 · Cited by 481
Self-citationThe internal thioester and the covalent binding properties of the complement proteins C3 and C4
Law, S. K. A., & Dodds, A. W. (1997) · Protein Science · doi:10.1002/pro.5560060201 · Cited by 373
Structure of C3b reveals conformational changes that underlie complement activity
Janssen, B. J. C., Christodoulidou, A., McCarthy, A., Lambris, J. D., & Gros, P. (2006) · Nature · doi:10.1038/nature05172 · Cited by 369
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Cited by
Complement System Part I – Molecular Mechanisms of Activation and Regulation
Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00262 · Cited by 1,620
Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
Chen, F., Wang, G., Griffin, J. I., Brenneman, B., Banda, N. K., Holers, V. M., Backos, D. S., Wu, L., Moghimi, S. M., & Simberg, D. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.269 · Cited by 599
Complement component C3 – The “Swiss Army Knife” of innate immunity and host defense
Ricklin, D., Reis, E. S., Mastellos, D. C., Gros, P., & Lambris, J. D. (2016) · Immunological Reviews · doi:10.1111/imr.12500 · Cited by 484
Self-citationComplement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Ricklin, D., & Lambris, J. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203487 · Cited by 478
Self-citationThe renaissance of complement therapeutics
Ricklin, D., Mastellos, D. C., Reis, E. S., & Lambris, J. D. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.156 · Cited by 379
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Metadata
- Authors
- Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R. S., Lambris, J. D., & Gros, P.
- Venue
- Science
- Published
- 2010-12-24
- Volume
- 330
- Issue
- 6012
- Pages
- 1816-1820
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084969272
- Cited by
- 288
- References
- 33
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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