The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift
Abstract
Gut Stem Cell Replacement: Gut cell turnover is characteristically rapid and relies on stem cells in the crypts that lie between the intestinal villi. The prevailing view is that stem cell division is asymmetric with one daughter retaining a stem cell character; however, this pattern of stem cell turnover does not always apply. Using long-term lineage tracing, Lopez-Garcia et al. (p. 822 , published online 23 September) showed that the loss of a stem cell was compensated for by the multiplication of a neighboring cell. The rate of stem-cell loss was found to be equivalent to the rate of cell division, indicating that symmetric cell division was the rule for gut stem cells and implying stochastic expansion, contraction, and extinction of clones occurs.
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Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue
Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J. C., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J., & Näthke, I. S. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.12.007 · Cited by 242
Cited by
Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769
Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951
Self-citationType 2 alveolar cells are stem cells in adult lung
Barkauskas, C. E., Cronce, M. J., Rackley, C. R., Bowie, E. J., Keene, D. R., Stripp, B. R., Randell, S. H., Noble, P. W., & Hogan, B. L. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68782 · Cited by 1,776
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238
The intestinal crypt, a prototype stem cell compartment
Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223
Metadata
- Authors
- Lopez-Garcia, C., Klein, A. M., Simons, B. D., & Winton, D. J.
- Venue
- Science
- Published
- 2010-11-05
- Volume
- 330
- Issue
- 6005
- Pages
- 822-825
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065220128
- Cited by
- 645
- References
- 2
- FWCI
- 18.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lopez-Garcia, C., Klein, A. M., Simons, B. D., & Winton, D. J. (2010). Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift. Science. https://doi.org/10.1126/science.1196236
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