Cited by 1,223Digestive system and related healthCancer Cells and MetastasisHematopoietic Stem Cell Transplantation

The intestinal crypt, a prototype stem cell compartment

Open access
Clevers, Hans·2013·Cell

Abstract

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2013.07.004

Cites

128 of 128 references verified0 citation errors · 0 not checkable

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  • Intestinal proliferation rates are high.

    “Whereas in the hematopoietic system, stem cell turnover is very low, proliferation rates in the intestine are very high.98”

    From Aging of hematopoietic stem cells (2018) · cites this paper as [98]

  • Hematopoietic stem cell turnover is low.

    “Whereas in the hematopoietic system, stem cell turnover is very low, proliferation rates in the intestine are very high.98”

    From Aging of hematopoietic stem cells (2018) · cites this paper as [98]

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Authors
Clevers, H.
Affiliations
Royal Netherlands Academy of Arts and Sciences (NL)
Corresponding author
Clevers, Hans
Venue
Cell
Publisher
Elsevier BV
Published
2013-07
Volume
154
Issue
2
Pages
274-284
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2053352622
Cited by
1,223
References
128
Citations by year
2026: 81 · 2025: 93 · 2024: 89 · 2023: 88 · 2022: 117 · 2021: 104 · 2020: 121 · 2019: 91 · 2018: 109 · 2017: 97 · 2016: 84 · 2015: 70 · 2014: 68 · 2013: 11
FWCI
9.39
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
intestinal crypts, intestinal stem cells, adult stem cells, self-renewal, intestinal epithelium, lineage tracing, asymmetric cell division, quiescence, stem cell exhaustion, tissue homeostasis
MeSH terms
Animals, Humans, Intestinal Mucosa, Mice, Transgenic, Cell Culture Techniques, Receptors, G-Protein-Coupled, Mice, Adult Stem Cells, Wnt Signaling Pathway

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