The intestinal crypt, a prototype stem cell compartment
Open accessAbstract
Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion.
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Intestinal proliferation rates are high.
“Whereas in the hematopoietic system, stem cell turnover is very low, proliferation rates in the intestine are very high.98”
From Aging of hematopoietic stem cells (2018) · cites this paper as [98]
Hematopoietic stem cell turnover is low.
“Whereas in the hematopoietic system, stem cell turnover is very low, proliferation rates in the intestine are very high.98”
From Aging of hematopoietic stem cells (2018) · cites this paper as [98]
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- Authors
- Clevers, H.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Clevers, Hans
- ORCID
- Clevers, Hans
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 154
- Issue
- 2
- Pages
- 274-284
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2053352622
- Cited by
- 1,223
- References
- 128
- Citations by year
- 2026: 81 · 2025: 93 · 2024: 89 · 2023: 88 · 2022: 117 · 2021: 104 · 2020: 121 · 2019: 91 · 2018: 109 · 2017: 97 · 2016: 84 · 2015: 70 · 2014: 68 · 2013: 11
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- intestinal crypts, intestinal stem cells, adult stem cells, self-renewal, intestinal epithelium, lineage tracing, asymmetric cell division, quiescence, stem cell exhaustion, tissue homeostasis
- MeSH terms
- Animals, Humans, Intestinal Mucosa, Mice, Transgenic, Cell Culture Techniques, Receptors, G-Protein-Coupled, Mice, Adult Stem Cells, Wnt Signaling Pathway
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