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Cited by 344

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

Reddy, Janardan K., Krishnakantha, T. P.·1975·Science
DOI 10.1126/science.1198095
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Abstract

Two hypolipidemic compounds [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid, and 2-chloro-5-(3,5-dimethylpiperidinosulfonyl)benzoic acid (tibric acid) greatly increased the number of peroxisomes (microbodies) in liver cells of rats and mice. This augmented peroxisome population was accompanied by significant elevation of liver catalase activity. These two hypolipidemic peroxisome proliferators are structurally different from ethyl α- p -chlorophenozyisobutyrate (clofibrate) and other hypolipidemic, aryloxyisobutyrate derivatives which cause hepatic peroxisome proliferation. Induction of peroxisome proliferation by these structurally unrelated hypolipidemic compounds suggests a possible relation between hepatic peroxisome proliferation and hypolipidemia.

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Metadata

Authors
Reddy, J. K., & Krishnakantha, T. P.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1975-11-21
Volume
190
Issue
4216
Pages
787-789
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1198095
OpenAlex
W2067421512
Cited by
344
References
22
FWCI
5.71
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate. https://app.cochat.ai/papers/10.1126/science.1198095
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Reddy, J. K., & Krishnakantha, T. P. (1975). Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate. Science. https://doi.org/10.1126/science.1198095

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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